Region 2 Regional Medical Library, NNLM - The Medical University of South Carolina (MUSC) Libraries will support the mission of the Network of the National Library of Medicine (NNLM) to advance the progress of medicine and improve the public’s health by ensuring broad access to biomedical and health information resources and data for U.S. researchers, health professionals, public health practitioners, educators, and the public. Located in Charleston, South Carolina, the MUSC Libraries serve as the Regional Medical Library (RML) for NNLM Region 2, encompassing Florida, Georgia, Mississippi, Alabama, South Carolina, Tennessee, the Commonwealth of Puerto Rico, and the U.S. Virgin Islands. Communities across Region 2 face persistent challenges related to health outcomes, poverty, natural disasters, and limited access to broadband internet, all of which affect individuals' and organizations' ability to access and use reliable health information. To address these challenges, the RML employs a multi-pronged approach to build and sustain strong, collaborative relationships with Network members using a variety of communication, training, engagement, funding, and service strategies. These efforts create multiple, flexible pathways for members to engage with Region 2, the NNLM Offices and Centers, and the broader mission of the National Library of Medicine (NLM). The RML leverages data and tools from a broad range of national organizations, including the National Area Health Education Center, BroadbandNow, the Centers for Disease Control and Prevention, the Health Resources and Services Administration, and the National Rural Health Association to support regional partners in addressing information access, workforce development, and regional health needs. Through these coordinated efforts, the RML seeks to strengthen the capacity of organizations across Region 2 to support informed decision-making, improve health outcomes, and improve access to trusted health information. The MUSC Libraries request $607,452, including indirect costs, for the period May 1, 2026, through April 30, 2027, to support the completion, evaluation, documentation, and transition of NNLM Region 2 activities.