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Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability

Award Number: UG3DA048510
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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ABSTRACT Tobacco use disorder (TUD), like other drugs of abuse, is associated with deficits in prefrontal mediated inhibitory control (IC)—the ability to stop pre-potent behavioral responding. We recently reported findings showing that IC task-based functional connectivity (tbFC) between the right inferior frontal gyrus (r.IFG) and thalamus (corticothalamic circuit) mediated the association between successful inhibition and smoking lapse / relapse vulnerability in the laboratory and in a smoking cessation study. Preliminary data from our laboratory shows that using intermittent theta burst stimulation (iTBS)—which induces long-term potentiation and putatively strengthens network activity—to the r.IFG significantly improves inhibitory control task performance among individuals with TUD. The goal of this proposal is to examine the mechanistic underpinnings of the effects of TBS on corticothalamic mediated inhibitory control and smoking and evaluate whether modulating corticothalamic tbFC translates to improved inhibitory control and reducing smoking lapse/relapse among individuals with TUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Drug Abuse and Addiction Research Programs	000	3	10/25/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Drug Abuse and Addiction Research Programs	001	3	1/28/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$320,000
2021	2020	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Drug Abuse and Addiction Research Programs	005	3	3/23/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2020	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Drug Abuse and Addiction Research Programs	004	3	3/1/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$182,734
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Abuse and Addiction Research Programs	000	2	1/27/2021	NON-COMPETING CONTINUATION	-$320,000
2021	2020	UNIVERSITY OF MISSOURI SYSTEM	316 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Drug Abuse and Addiction Research Programs	006	3	9/3/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Abuse and Addiction Research Programs	003	2	3/1/2021	NON-COMPETING CONTINUATION	-$40,401
2021	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Abuse and Addiction Research Programs	002	1	3/1/2021	NEW	-$142,333
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $360,401 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Abuse and Addiction Research Programs	000	2	3/25/2020	NON-COMPETING CONTINUATION	$360,401
														Subtotal = $360,401

Issue Date FY: 2019 ( Subtotal = $373,744 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Abuse and Addiction Research Programs	000	1	5/9/2019	NEW	$373,744
														Subtotal = $373,744

Grand Total All Awards = $734,145

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Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability

Award Number: UG3DA048510

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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