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Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center

Award Number: UG1HD107692
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/10/2021
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center - The need for more precise nutrition advice is widely recognized, yet specific differences in genetic, epigenetic, microbiome and phenotypic drivers of individual variability to diet are not well known. The National Institutes of Health initiative to fund Nutrition for Precision Health (NPH), powered by the All of Us Research Program, will enable major progress in the field of precision nutrition. Here we propose Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center (UNC-CC). Because chronic inflammation promotes the pathogenesis of a wide range of diseases, including obesity, type 2 diabetes, and cardiovascular, neoplastic, and neurodegenerative disorders, we draw upon the anti-inflammatory Mediterranean diet as a viable strategy to improve systemic inflammation and reduce risk for many chronic diseases and their complications. A body of literature has emerged that demonstrates both genotypically- and phenotypically-driven differential responses to the Mediterranean diet relative to a range of outcomes. Our proposal will address the critical need to understand variability in physiologic responses to diet, anchored by the theme of inflammation. Diet preparation will be facilitated by two clinical locations with metabolic kitchens: the UNC Nutrition Research Institute (UNC-NRI) in Kannapolis, NC, and the Chapel Hill campus of UNC (UNC-CH). The UNC-NRI draws from relatively rural communities and UNC-CH draws from relatively urban communities. Specific Aims are: Aim 1. To participate actively in the Year 1 planning process and beyond, engaging across the NPH consortium to collaboratively develop and execute the final study protocol. Aim 2. To execute NPH Module 1. Following participant enrollment into All of Us, we will enroll and complete the Module 1 protocol for a total of 2,000 NPH participants (25% at UNC-NRI; 75% at UNC-CH), including two study visits with a 2-week remote data capture period and a mixed meal challenge test. Aim 3. To execute NPH Module 2. A subset of 500 Module 1 participants will complete a free-living, controlled feeding study of three 2-week diet intervention periods, separated by 3-week washout periods. Diets include: The Mediterranean diet adapted for the US (Med-USA; 40% fat calories, 40% carbohydrate), the Med-USA modified for high healthy fat content (60% fat calories, 20% carbohydrate), and Med-USA modified for high healthy carbohydrate content (20% fat calories, 60% carbohydrate). Differential effects of the diets on outcomes comprising inflammatory markers and metabolic parameters from the mixed meal challenge will be tested across genotypic and phenotypic subgroups, focusing on weight status, age, and diabetes status. The UNC-CC team brings impressive interdisciplinary strength in nutrition (basic science to public health) and has the capacity and experience in complex, multi-site trials to ensure the scientific rigor needed to execute this study. Results will generate predictive algorithms to inform individualized dietary guidance to improve health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,249,387 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	000	5	1/5/2026	NON-COMPETING CONTINUATION	$2,249,387
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	001	5	3/30/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,249,387

Issue Date FY: 2025 ( Subtotal = $3,562,933 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	000	4	12/16/2024	NON-COMPETING CONTINUATION	$3,562,933
														Subtotal = $3,562,933

Issue Date FY: 2024 ( Subtotal = $3,874,619 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	000	3	1/31/2024	NON-COMPETING CONTINUATION	$3,174,619
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	002	3	8/24/2024	NON-COMPETING CONTINUATION	$700,000
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	001	3	2/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,874,619

Issue Date FY: 2023 ( Subtotal = $2,747,944 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	000	2	12/1/2022	NON-COMPETING CONTINUATION	$2,747,944
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	001	2	3/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,747,944

Issue Date FY: 2022 ( Subtotal = $1,879,925 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	000	1	12/10/2021	NEW	$1,879,925
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	003	1	4/26/2022	NEW	$0
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	001	1	2/1/2022	NEW	$0
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	002	1	3/16/2022	NEW	$0
														Subtotal = $1,879,925

Grand Total All Awards = $14,314,808

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Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center

Award Number: UG1HD107692

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/10/2021

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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