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UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies

Award Number: UG1HD040560
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/18/2001
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies - PROJECT SUMMARY/ ABSTRACT Despite decades of research, the rates of pregnancy complications, maternal and neonatal morbidity and mortality, and adverse long-term sequalae of pregnancy remain unacceptably high, presenting enormous clinical care and public health needs. The University of North Carolina at Chapel Hill (UNC) Maternal Fetal Medicine Units (MFMU) Network clinical center is committed to addressing these major public health burdens by continuing to contribute to high-quality, definitive multi-site collaborative clinical studies. The UNC MFMU includes UNC Health Care (UNC-Chapel Hill and UNC Rex hospitals) and WakeMed Health (WakeMed Raleigh and WakeMed North hospitals); combined, there were 15,175 deliveries in 2021. UNC MFMU sites have >30 years of MFMU perinatal research experience and include three Level IV and one Level Ill NICU, with established graduate follow-up programs for each hospital system. UNC has an established track record of success as a strong performing, active member of the NICHD MFMU over the last 22 years. The UNC MFMU has completed 22 studies; an additional 9 are currently active. Several currently active studies were initiated during the peak pandemic period; despite this timing, the UNC MFMU maintained excellent recruitment and data quality, demonstrating our perseverance and flexibility to rise to ongoing challenges. We consistently enroll racially, ethnically, and socioeconomically diverse participants, and averaged 6th overall in recruiting from the 2016-2022 cycle. The continued success of the UNC MFMU is supported by our solid infrastructure, ability to successfully recruit from our large diverse patient population, experienced and dedicated team, and culture of clinical research. Further, our expertise and unique strengths in areas including preterm birth, lactation, substance use disorder, disparities, translational research, environmental science, epidemiology, and beyond will prove invaluable to the MFMU Network community. The UNC MFMU is perfectly suited to continue to make substantial contributions to improve obstetric care, with strengths directly aligned to support the MFMU Congressional and public health goals. We will leverage UNC's unique resources to design and implement innovative multi-site, collaborative research proposals to address priority areas as outlined by three overarching aims. Aim 1: Reduce rates of PTB and related morbidity by advancing novel, solution-oriented research. Aim 2: Increase pregnant and lactating people's access to safe and effective therapies to prevent and treat medical and obstetric complications. Aim 3: Develop optimal strategies to protect mothers and babies affected by ongoing and future public health crises, including mental health disorders, substance abuse disorders, environmental hazards, and pandemics. UNC's track record of success for over 20 years, combined with superb infrastructure and personnel and innovative research plans that leverage unique site-specific resources will result in sustained clinical and public health impacts in optimizing perinatal health outcomes for pregnant people and their offspring.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	26	11/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $337,136 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	26	3/28/2025	NON-COMPETING CONTINUATION	$337,136
														Subtotal = $337,136

Issue Date FY: 2024 ( Subtotal = $339,544 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	003	25	4/30/2024	NON-COMPETING CONTINUATION	$33,955
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	002	25	3/22/2024	NON-COMPETING CONTINUATION	$305,589
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	24	3/5/2024	COMPETING CONTINUATION	$216
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	23	3/5/2024	NON-COMPETING CONTINUATION	-$216
														Subtotal = $339,544

Issue Date FY: 2023 ( Subtotal = $342,100 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	24	3/31/2023	COMPETING CONTINUATION	$342,100
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	23	3/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $342,100

Issue Date FY: 2022 ( Subtotal = $304,722 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	002	23	4/18/2022	NON-COMPETING CONTINUATION	$304,722
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	22	11/11/2021	COMPETING CONTINUATION	$48
2022	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	21	11/11/2021	NON-COMPETING CONTINUATION	-$48
														Subtotal = $304,722

Issue Date FY: 2021 ( Subtotal = $275,149 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	22	5/17/2021	COMPETING CONTINUATION	-$36,649
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	22	3/29/2021	COMPETING CONTINUATION	$311,798
														Subtotal = $275,149

Issue Date FY: 2020 ( Subtotal = $263,009 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	21	3/20/2020	NON-COMPETING CONTINUATION	$263,009
														Subtotal = $263,009

Issue Date FY: 2019 ( Subtotal = $268,747 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	20	3/27/2019	NON-COMPETING CONTINUATION	$268,747
														Subtotal = $268,747

Issue Date FY: 2018 ( Subtotal = $275,546 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	19	5/1/2018	NON-COMPETING CONTINUATION	$27,556
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	19	3/10/2018	NON-COMPETING CONTINUATION	$247,990
														Subtotal = $275,546

Issue Date FY: 2017 ( Subtotal = $282,173 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	18	3/3/2017	NON-COMPETING CONTINUATION	$253,955
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	001	18	6/13/2017	NON-COMPETING CONTINUATION	$28,218
														Subtotal = $282,173

Issue Date FY: 2016 ( Subtotal = $288,799 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Child Health and Human Development Extramural Research	000	17	3/8/2016	COMPETING CONTINUATION	$288,799
														Subtotal = $288,799

Grand Total All Awards = $2,976,925

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UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies

Award Number: UG1HD040560

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/18/2001

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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