Monday, June 30, 2025 6/30/2025

Maternal-Fetal Medicine Units (MFMU) Network

Award Number: UG1HD027869
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1991
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Maternal-Fetal Medicine Units (MFMU) Network - The Maternal-Fetal Medicine (MFM) Division of the University of Alabama at Birmingham (UAB) submits this application to continue as a clinical center of the NICHD MFM Units (MFMU) Network. We present our center's attributes and longstanding record of exceptional performance in the Network. We remain committed to the Network's goals to improve obstetric care, pregnancy health, and outcomes for pregnant/lactating people and their babies. Our internationally-renowned, Center for Women's Reproductive Health (CWRH), the home of our MFMU center, has a research staff of >50 and extensive successful experience leading large clinical trials and observational studies to transform maternal and infant health both in and outside the Network. As an MFMU center for >30 years, UAB has consistently played a leadership role in providing stewardship for the Network at the Steering Committee and sub-committee levels, conducted Network trials with the highest efficiency of any center, and led all centers in the presentation and publication of data generated. Among 32 clinical centers in MFMU history, a UAB investigator first-authored >17% of Network publications (14.5% since 2016) and 18% of presentations at national meetings. Current members of our team have accumulated >250 MFMU person-years' experience of active participation supporting MFMU projects; our research staff similarly cumulate >275 MFMU person-years. Alan Tita, MD, PhD (CWRH Director) and Brian Casey, MD will continue as PI and Alternate PI, respectively. Our team includes 2 previous MFMU PI's and 7 members who have served or currently serve as Network protocol chairpersons or Subcommittee members. We continue to enroll and retain the highest number of participants in many network studies; adjusted for the available population, we enroll the highest of any MFMU site. Our enriched high-risk and diverse population (>50% black), strong culture of research support and collaboration, 24/7 research staff coverage and high proportion of screen-eligible patients successfully enrolled into network studies allow us to sustain and continue this high level of performance. If successful in this renewal, we will strengthen our collaboration with Ochsner Health System as a satellite site. We will deploy our extensive research resources - data management systems, recruitment resources including programming into electronic health records, transdisciplinary investigative team and experienced personnel - to conceive, design and implement new innovative and impactful studies. We will leverage the network to train future research leaders including our next PI. Our record of success extends to leadership of complementary large non-MFMU consortia conducting impactful clinical trials and follow-up studies towards similar goals, including the Chronic Hypertension and Pregnancy consortium and the American Heart Association Health Equity Research Network on Disparities in Maternal-Infant Health Outcomes. Since 2016 our core MFM investigators had >260 non-MFMU peer-reviewed publications. We believe our center's attributes detailed herein, the sustained record of success, and our plans to prioritize MFMU studies position us for success during the new 7-year cycle.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $326,700 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	36	3/28/2025	NON-COMPETING CONTINUATION	$326,700
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	002	36	5/1/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	35	11/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $326,700

Issue Date FY: 2024 ( Subtotal = $326,700 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	002	35	3/22/2024	NON-COMPETING CONTINUATION	$294,030
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	003	35	4/30/2024	NON-COMPETING CONTINUATION	$32,670
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	34	3/5/2024	COMPETING CONTINUATION	$29,410
2024	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	33	3/5/2024	NON-COMPETING CONTINUATION	-$29,410
														Subtotal = $326,700

Issue Date FY: 2023 ( Subtotal = $326,700 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	34	3/31/2023	COMPETING CONTINUATION	$326,700
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	33	3/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $326,700

Issue Date FY: 2022 ( Subtotal = $297,000 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	002	33	4/18/2022	NON-COMPETING CONTINUATION	$297,000
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	32	11/10/2021	COMPETING CONTINUATION	$11,716
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	31	11/10/2021	NON-COMPETING CONTINUATION	-$11,716
														Subtotal = $297,000

Issue Date FY: 2021 ( Subtotal = $262,091 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	002	32	5/17/2021	COMPETING CONTINUATION	-$34,909
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	32	3/29/2021	COMPETING CONTINUATION	$297,000
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	32	4/6/2021	COMPETING CONTINUATION	$0
														Subtotal = $262,091

Issue Date FY: 2020 ( Subtotal = $279,300 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	31	3/18/2020	NON-COMPETING CONTINUATION	$279,300
														Subtotal = $279,300

Issue Date FY: 2019 ( Subtotal = $279,300 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	30	3/27/2019	NON-COMPETING CONTINUATION	$279,300
														Subtotal = $279,300

Issue Date FY: 2018 ( Subtotal = $279,300 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	29	5/1/2018	NON-COMPETING CONTINUATION	$27,929
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	29	3/10/2018	NON-COMPETING CONTINUATION	$251,371
														Subtotal = $279,300

Issue Date FY: 2017 ( Subtotal = $279,300 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	001	28	6/13/2017	NON-COMPETING CONTINUATION	$27,929
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	28	3/3/2017	NON-COMPETING CONTINUATION	$251,371
														Subtotal = $279,300

Issue Date FY: 2016 ( Subtotal = $1 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Child Health and Human Development Extramural Research	000	27	3/15/2016	COMPETING CONTINUATION	$1
														Subtotal = $1

Grand Total All Awards = $2,656,392

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Maternal-Fetal Medicine Units (MFMU) Network

Award Number: UG1HD027869

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1991

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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