Thursday, November 21, 2024 11/21/2024

NIDA Clinical Trials Network: Big South/West Node Supplemental - CURB CTN0109 & KMD CTN0132

Award Number: UG1DA020024
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT The Big South/West Node of the NIDA Clinical Trials Network (CTN) represents an expansion of the Texas Node that has been a part of the CTN since 2005. With this expansion, the node will now be guided by the shared leadership of Madhukar H. Trivedi, MD of University of Texas Southwestern Medical Center (UTSW) Steven Shoptaw, PhD of UCLA, and Jennifer S. Potter, PhD, MPH, of UT Health Science Center at San Antonio (UTHSCSA). This fourth competing renewal application builds on our successful track record of leading CTN trials, being good network partners by providing excellent sites for multi-site studies, high productivity in publishing, and training the next generation of scientists. During the 2015-2020 funding cycle, our team developed and led: the largest pharmacotherapy trial for the treatment of methamphetamine use disorder to date (extended-release naltrexone plus high-dose bupropion; CTN0068 ADAPT-2), an in-depth study of the causes of death in a cohort of people living with HIV/HCV and substance use disorder (CTN0064A1), and an implementation study to develop and deploy universal screening for opioid use disorder and measurement based care using buprenorphine (CTN0090 MBC4OUD). Finally, a study testing transcranial magnetic stimulation (TMS) as a treatment for stimulant use disorder has been approved for development, in collaboration with the Southern Consortium Node (CTN0108). For this renewal application, we capitalize on the experience of the Multiple PIs, who collectively have expertise in the treatment of stimulants, the treatment of and public health response to the opioid crisis, and the treatment and care of HIV. Additional investigators bring content expertise spanning addiction science and clinical care, translational science, dissemination and implementation science, informatics, and trial implementation. The expanded Big South/West Node is named to denote the importance of including geographic regions in the South that have historically not been represented within the CTN (i.e., Arkansas, Oklahoma, Louisiana). This geographical expansion provides greater access to diverse patient populations (e.g., diverse racial and ethnic groups; underinsured; underserved; native [American Indian] and immigrant groups) within diverse settings (e.g., rural, urban). Our existing partnerships with primary care networks, large health care systems, and use of electronic health records (EHR) to positively impact substance use, has been further broadened to include multiple statewide networks and resources in new partner states. Our research agenda includes a focus on the fourth wave of the opioid epidemic, building upon the expertise of our investigators in treating stimulant and opioid use disorders, and the changing needs of the regions we serve. Our team has experience with innovative study designs that target all areas of the translational science continuum, and equip our Node to successfully and significantly improve the care of persons who misuse substances.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	20	10/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $10,744,947 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	20	6/11/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	20	9/25/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	20	3/11/2024	NON-COMPETING CONTINUATION	$5,228,909
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	20	9/17/2024	SUPPLEMENT FOR EXPANSION	$4,935,061
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	20	8/29/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	20	7/18/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	20	4/30/2024	NON-COMPETING CONTINUATION	$580,977
2024	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	19	3/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $10,744,947

Issue Date FY: 2023 ( Subtotal = $8,888,943 )
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	19	8/2/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	19	7/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	19	3/2/2023	NON-COMPETING CONTINUATION	$8,888,943
2023	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	18	1/13/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	18	2/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,888,943

Issue Date FY: 2022 ( Subtotal = $3,315,360 )
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	18	9/23/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	18	9/13/2022	SUPPLEMENT FOR EXPANSION	$2,533,716
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	18	5/27/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	18	5/31/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	18	9/21/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	18	6/30/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	18	3/1/2022	NON-COMPETING CONTINUATION	$781,644
2022	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	17	10/25/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,315,360

Issue Date FY: 2021 ( Subtotal = $10,752,862 )
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	009	17	9/13/2021	NON-COMPETING CONTINUATION	$3,907,421
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	007	17	7/15/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	000	17	2/22/2021	NON-COMPETING CONTINUATION	$793,442
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	005	17	5/19/2021	NON-COMPETING CONTINUATION	$5,874,807
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	006	17	6/22/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	008	17	8/27/2021	SUPPLEMENT FOR EXPANSION	$177,192
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	004	16	5/12/2021	COMPETING CONTINUATION	$1,056,645
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	002	16	3/23/2021	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	001	16	3/22/2021	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	003	15	5/12/2021	SUPPLEMENT FOR EXPANSION	-$1,056,645
														Subtotal = $10,752,862

Issue Date FY: 2020 ( Subtotal = $9,991,794 )
2020	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	001	16	6/1/2020	COMPETING CONTINUATION	$4,398,040
2020	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	002	16	8/25/2020	SUPPLEMENT FOR EXPANSION	$5,593,754
2020	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	000	15	3/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $9,991,794

Issue Date FY: 2019 ( Subtotal = $2,881,130 )
2019	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	003	15	6/24/2019	SUPPLEMENT FOR EXPANSION	$1,597,849
2019	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	000	14	2/8/2019	SUPPLEMENT FOR EXPANSION	$304,936
2019	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	002	15	4/4/2019	NON-COMPETING CONTINUATION	$766,319
2019	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	001	14	3/22/2019	SUPPLEMENT FOR EXPANSION	$212,026
														Subtotal = $2,881,130

Issue Date FY: 2018 ( Subtotal = $2,725,524 )
2018	2018	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	000	14	4/26/2018	NON-COMPETING CONTINUATION	$766,319
2018	2018	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Abuse and Addiction Research Programs	001	14	7/27/2018	SUPPLEMENT FOR EXPANSION	$1,959,205
														Subtotal = $2,725,524

Issue Date FY: 2017 ( Subtotal = $3,124,701 ) (Continued on the next page)
Grand Total All Awards = $56,208,387

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NIDA Clinical Trials Network: Big South/West Node Supplemental - CURB CTN0109 & KMD CTN0132

Award Number: UG1DA020024

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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