Friday, December 12, 2025 12/12/2025

NIDA Clinical Trials Network: Big South/West Node

Award Number: UG1DA020024
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2005
PERIOD OF PERFORMANCE END DATE: 02/29/2032

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NIDA Clinical Trials Network: Big South/West Node - The Big South/West Node of the NIDA Clinical Trials Network (CTN) has been a part of the CTN since 2005 (originally as the Texas Node, expanding to the Big South/West Node in 2020). The Node is led by the shared leadership of Madhukar H. Trivedi, MD of University of Texas Southwestern Medical Center (UTSW), providing expertise in multisite clinical trials, and Steven Shoptaw, PhD of University of California Los Angeles (UCLA), providing internationally recognized expertise in stimulant use disorder (StUD). This fourth competing renewal application builds on our successful track record of leading CTN trials, being excellent network partners by providing exceptional sites for multi-site studies, high productivity in publishing, and training the next generation of scientists. During the 2020-2025 funding cycle, our team completed the largest pharmacotherapy trial for the treatment of methamphetamine use disorder to date (CTN-0068, ADAPT-2), which now has six publications and three additional manuscripts under review. We also developed and led four large randomized controlled concepts for novel interventions in adults with stimulant use disorders (CTN-0108 STIMULUS, CTN-0109 CURB-2, CTN-0110 MURB, CTN-0132 KMD) and two implementation study concepts for: universal screening and measurement-based care for buprenorphine treatment (CTN-0090, MBC4OUD), and remote methadone monitoring (CTN-0120, RMIST). For this renewal application, we capitalize on the experience of the PIs, who collectively have expertise in the treatment of StUD, treatment of and public health response to the opioid crisis, and treatment and care of comorbid conditions. Additional investigators bring content expertise spanning addiction science and clinical care, translational science, dissemination and implementation science, and trial implementation. Our geographical region is unique in that the South and West are experiencing a public health crisis of overdose deaths that involve stimulants. We will continue our efforts to conduct large multi-site studies on StUD treatments. In addition, our existing partnerships with primary care networks, emergency settings, and medical specialty care settings (e.g., cardio-pulmonary clinics) will allow us to scale up efficacious treatments in these healthcare settings. Our research agenda includes 1) conducting clinical trials on new and repurposed treatments for StUD; 2) implementing efficacious treatments in clinical settings to address comorbid conditions; 3) conducting implementation science to disseminate research findings and impact policy; and 4) exploring biomarkers to improve StUD treatments. Our team has experience with innovative study designs that target all areas of the translational science continuum and equip our Node to successfully and significantly improve the care of persons with StUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	21	12/2/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $7,716,176 )
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	21	3/20/2025	COMPETING CONTINUATION	$0
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	21	7/31/2025	SUPPLEMENT FOR EXPANSION	$3,235,924
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	21	7/29/2025	SUPPLEMENT FOR EXPANSION	$3,235,924
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	21	4/8/2025	SUPPLEMENT FOR EXPANSION	$5,606,566
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	21	1/17/2025	COMPETING CONTINUATION	$872,759
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	21	2/28/2025	COMPETING CONTINUATION	$0
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	008	21	7/31/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	21	6/30/2025	COMPETING CONTINUATION	$0
2025	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	21	7/29/2025	SUPPLEMENT FOR EXPANSION	-$5,234,997
2025	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	20	10/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,716,176

Issue Date FY: 2024 ( Subtotal = $10,744,947 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	20	9/17/2024	SUPPLEMENT FOR EXPANSION	$4,935,061
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	20	8/29/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	20	7/18/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	20	3/11/2024	NON-COMPETING CONTINUATION	$5,228,909
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	20	6/11/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	20	4/30/2024	NON-COMPETING CONTINUATION	$580,977
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	20	9/25/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	19	3/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $10,744,947

Issue Date FY: 2023 ( Subtotal = $8,888,943 )
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	19	7/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	19	3/2/2023	NON-COMPETING CONTINUATION	$8,888,943
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	19	8/2/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	18	1/13/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	18	2/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,888,943

Issue Date FY: 2022 ( Subtotal = $3,315,360 )
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	18	9/21/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	18	9/23/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	18	5/31/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	18	5/27/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	18	3/1/2022	NON-COMPETING CONTINUATION	$781,644
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	18	6/30/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	18	9/13/2022	SUPPLEMENT FOR EXPANSION	$2,533,716
2022	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	17	10/25/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,315,360

Issue Date FY: 2021 ( Subtotal = $10,752,862 )
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	000	17	2/22/2021	NON-COMPETING CONTINUATION	$793,442
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	007	17	7/15/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	009	17	9/13/2021	NON-COMPETING CONTINUATION	$3,907,421
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	008	17	8/27/2021	SUPPLEMENT FOR EXPANSION	$177,192
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	006	17	6/22/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	005	17	5/19/2021	NON-COMPETING CONTINUATION	$5,874,807
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	16	3/22/2021	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	004	16	5/12/2021	COMPETING CONTINUATION	$1,056,645
2021	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	002	16	3/23/2021	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	003	15	5/12/2021	SUPPLEMENT FOR EXPANSION	-$1,056,645
														Subtotal = $10,752,862

Issue Date FY: 2020 ( Subtotal = $9,991,794 ) (Continued on the next page)
2020	2020	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Drug Use and Addiction Research Programs	001	16	6/1/2020	COMPETING CONTINUATION	$4,398,040
Grand Total All Awards = $63,924,563

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NIDA Clinical Trials Network: Big South/West Node

Award Number: UG1DA020024

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2005

PERIOD OF PERFORMANCE END DATE: 02/29/2032

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