Thursday, November 21, 2024 11/21/2024

CTN145: Standard versus High Dose ED-Initiated Buprenorphine Induction Administrative Supplement 1

Award Number: UG1DA015831
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

EMS encounters for opioid overdose and withdrawal have escalated along with the national opioid use disorder (OUD) crisis. Despite the efficacy of buprenorphine treatment for patients with OUD, and effectiveness of initiation of buprenorphine in the emergency department (ED) setting, the treatment gap remains wide. Emergency Medical Services (EMS) is often the first encounter a person with OUD has with the healthcare system, either after overdose reversal or for treatment for moderate to severe opioid withdrawal. Unfortunately, some patients refuse transport, or leave against medical advice once they arrive in the ED. Thus, buprenorphine offered as out-of-hospital emergency care could provide a vital strategy opportunity for initiation of life saving treatment and referral for ongoing OUD care. Current evidence for EMS initiated buprenorphine is limited to small retrospective or nonrandomized prospective cohort studies. While promising, these studies suffer from lack of intervention fidelity, bias, and uncontrolled confounders. EMS-based research has the potential to expand the reach of ED- and outpatient-based OUD interventions, and significantly enhance availability of evidence-based addiction care into settings where preventing adverse consequences of untreated opioid use is critically important. During the 8-month project period, our Specific Aim is to: Develop a study protocol for prehospital EMS-initiated buprenorphine treatment for patients with OUD presenting with (a) overdose requiring a naloxone reversal or (b) acute opioid withdrawal to promote engagement in OUD treatment. Our approach will use a Delphi Consensus Method with a panel of emergency medicine, EMS, and OUD care content experts. The study protocol will be refined through subsequent focus groups with EMS personnel and patients with OUD to ensure protocol feasibility and acceptability. Over subsequent study years we will conduct a sequence of pragmatic controlled field studies to test implementation of the protocol, followed by a randomized trial to evaluate the effectiveness of EMS delivered buprenorphine on linkage to addiction treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$215,852 )
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	000	23	10/1/2024	SUPPLEMENT FOR EXPANSION	-$215,852
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	001	23	10/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = -$215,852

Issue Date FY: 2024 ( Subtotal = $12,668,009 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	004	23	4/24/2024	NON-COMPETING CONTINUATION	$1,191,629
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	007	23	9/10/2024	SUPPLEMENT FOR EXPANSION	$499,472
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	008	23	9/13/2024	SUPPLEMENT FOR EXPANSION	$252,248
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	005	23	6/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	006	23	7/18/2024	NON-COMPETING CONTINUATION	$0
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	002	23	3/8/2024	NON-COMPETING CONTINUATION	$10,724,660
2024	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	000	22	12/1/2023	NON-COMPETING CONTINUATION	$0
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	003	22	3/29/2024	NON-COMPETING CONTINUATION	$0
2024	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	001	22	2/9/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $12,668,009

Issue Date FY: 2023 ( Subtotal = $13,737,754 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	011	22	9/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	007	22	4/25/2023	NON-COMPETING CONTINUATION	$0
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	012	22	9/14/2023	SUPPLEMENT FOR EXPANSION	$2,549,046
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	003	22	2/16/2023	NON-COMPETING CONTINUATION	$9,739,294
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	009	22	5/16/2023	NON-COMPETING CONTINUATION	$0
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	008	22	5/12/2023	SUPPLEMENT FOR EXPANSION	$57,865
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	004	22	2/17/2023	SUPPLEMENT FOR EXPANSION	$105,525
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	010	22	5/25/2023	SUPPLEMENT FOR EXPANSION	$1,286,024
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	001	21	1/5/2023	NON-COMPETING CONTINUATION	$0
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	006	21	4/20/2023	NON-COMPETING CONTINUATION	$0
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	002	21	2/14/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	000	21	12/22/2022	NON-COMPETING CONTINUATION	$0
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	005	21	3/10/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $13,737,754

Issue Date FY: 2022 ( Subtotal = $10,668,379 ) (Continued on the next page)
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	024	21	9/29/2022	NON-COMPETING CONTINUATION	$0
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	022	21	9/2/2022	SUPPLEMENT FOR EXPANSION	$4,428,689
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	014	21	3/1/2022	NON-COMPETING CONTINUATION	$818,757
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	016	21	4/15/2022	SUPPLEMENT FOR EXPANSION	$771,914
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	020	21	7/8/2022	SUPPLEMENT FOR EXPANSION	$105,525
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	018	21	6/1/2022	NON-COMPETING CONTINUATION	$1,145,745
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	019	21	6/9/2022	NON-COMPETING CONTINUATION	$0
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	023	21	9/7/2022	SUPPLEMENT FOR EXPANSION	$1,638,420
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	021	21	8/19/2022	SUPPLEMENT FOR EXPANSION	$688,344
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	015	21	4/7/2022	SUPPLEMENT FOR EXPANSION	$1,070,985
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	000	20	11/17/2021	NON-COMPETING CONTINUATION	$0
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	017	20	5/27/2022	NON-COMPETING CONTINUATION	$0
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	013	19	1/12/2022	COMPETING CONTINUATION	$7,646,338
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	010	18	1/12/2022	SUPPLEMENT FOR EXPANSION	-$418,105
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	007	18	12/21/2021	SUPPLEMENT FOR EXPANSION	$417,988
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	003	18	11/23/2021	SUPPLEMENT FOR EXPANSION	-$417,988
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	008	18	12/21/2021	SUPPLEMENT FOR EXPANSION	$4,700,000
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	005	18	12/21/2021	SUPPLEMENT FOR EXPANSION	$2,314,092
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	001	18	11/23/2021	SUPPLEMENT FOR EXPANSION	-$2,314,092
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	009	18	1/12/2022	SUPPLEMENT FOR EXPANSION	-$2,110,246
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	011	18	1/12/2022	SUPPLEMENT FOR EXPANSION	-$417,988
2022	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Drug Use and Addiction Research Programs	006	18	12/21/2021	SUPPLEMENT FOR EXPANSION	$418,105
Grand Total All Awards = $86,617,263

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CTN145: Standard versus High Dose ED-Initiated Buprenorphine Induction Administrative Supplement 1

Award Number: UG1DA015831

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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