Friday, April 25, 2025
4/25/2025
Oklahoma Tribal, Rural, Urban Cancer Screening Trial ACCESS Hub - PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the NOSI identified as NOT-CA-24-111. All activities supported by this administrative supplement will occur in the Stephenson Cancer Center (SCC) Oklahoma Tribal, Rural, Urban Cancer Screening Trial (OK TRUST) ACCESS Hub, a member site of the National Cancer Institute (NCI) Cancer Screening Research Network (CSRN). The overarching goal for the OK TRUST ACCESS Hub is to enhance capacity for increasing cancer screening trials accrual and participation among tribal, rural and urban populations across Oklahoma. OK TRUST is designed to enroll large numbers of participants from tribal, rural, and low-income urban populations, which have disproportionately high cancer rates but low participation in clinical trials at the national level. Given the historical distrust between American Indian communities and academic researchers, it is notable that several Tribes and American Indian-serving clinical facilities are participating in this project, which collects biospecimen data. Funds from this Administrative Supplement request will address critical aspects of the Vanguard Study identified since our original application. Specifically, we seek funding for two additional Cancer Screening Research Coordinators (CSRCs) to manage the complex requirements of recruitment, enrollment, consent, data collection, participant retention, and navigation of diagnostic testing. One CSRC will be fluent in Spanish to support affiliates with large Spanish-speaking populations, and another will have expertise in tribal data protection. Additionally, we request funding for participant gift cards to improve retention, including for a two-year follow-up interval, which was not included in our original budget. We also seek funds to cover the costs of venipuncture biospecimen collection at Affiliate Organization facilities, some of which will rely on study funds for this purpose. Since our original application, we have learned that a higher proportion of results from the two multi-cancer early detection (MCED) tests selected for the Vanguard Study will be positive than originally estimated. As a result, we are requesting additional funding for diagnostic testing, beyond the in-kind contribution from the SCC included in the original proposal. This supplemental funding will enable OK TRUST to complete its proposed aims for the Vanguard Study, including enrolling a diverse participant pool and providing follow-up for those with positive results. It will also address the additional complexity and costs identified since the original application, allowing the OK TRUST ACCESS Hub to successfully recruit participants from high-cancer-rate communities that have often been excluded from cancer research.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).