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Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN)

Award Number: UG1CA286941
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/14/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN) - Leveraging decades of NCI investments in clinical trials, data infrastructure, and cancer screening research, the I-SCREEN (Improving Strategies for Cancer Reduction through Early-detection and ENgagement) ACCESS Hub is well-positioned to efficiently and effectively address pressing issues around the emergence of new technologies for cancer screening. In collaboration with other ACCESS Hubs, we will evaluate the benefits and harms of new cancer screening technologies and their impacts on a representative sample of the United States (US) population. We will build on the University of Colorado Cancer Center’s (UCCC) successful administration of large cancer screening trials, including the Prostate, Lung, Ovarian, & Colorectal (PLCO) Cancer Screening Trial and the National Lung Screening Trial (NLST), along with their well-established Colorado Cancer Screening Program (CCSP), a statewide cancer screening network reaching the catchment area of the center. UCCC’s network of rural health centers will be complemented by Kaiser Permanente Colorado’s (KPCO) inclusive population from Colorado’s Front Range and extend existing collaborations between UCCC and KPCO in the NCI-funded Colorado Implementation Science Center for Cancer Control (COISC3). We will also build on the synergy between KPCO and Kaiser Permanente Hawaii (KPHI) as the only two sites in NCI’s Population-based Research to Optimize the Screen Process (PROSPR) Consortium that are also part of the Connect NCI Cohort Initiative and the Kaiser Permanente (KP) Research Bank (KP’s national biobank), both recruiting healthy patients and collecting blood biospecimens. The I-SCREEN Consortium consists of an NCI-designated Cancer Center, two integrated care delivery systems, one rural/suburban health system accepting >25 types of insurance, and one rural critical access hospital system. Our long-term goal is to reduce cancer-related mortality by rapidly investigating emerging, novel screening technologies in a population that is representative of the US population to ensure that efficacious new technologies have a broad reach. To accomplish this goal, we will: 1) collaborate with NCI, the CSRN Centers and ACCESS Hubs to build an ecosystem to evaluate new cancer screening technologies and strategies in multiple clinical settings; 2) Develop and execute the Vanguard feasibility study to inform the design of trials to evaluate new technologies for cancer screening of populations that are representative of the US population; and, 3) increase the impact of CSRN by collaborating with NCI to build a robust data/biospecimen repository available to CSRN investigators and external investigators for research to improve cancer screening and early detection and establish the provisioning of publicly available CSRN datasets. Through centralized Administrative, Recruitment and Biospecimens, Engagement, and Data Cores, we will ensure ACCESS Hub collaboration, communication, and progress towards CSRN deliverables. I-SCREEN will be a model for high-impact, translational research to test emerging cancer screening technologies to reduce cancer mortality in the US.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $785,445 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Control	001	3	2/26/2026	NON-COMPETING CONTINUATION	$0
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Control	000	3	1/20/2026	NON-COMPETING CONTINUATION	$785,445
														Subtotal = $785,445

Issue Date FY: 2025 ( Subtotal = $1,428,173 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	2	5/12/2025	SUPPLEMENT FOR EXPANSION	$534,586
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Control	002	2	5/23/2025	NON-COMPETING CONTINUATION	$89,358
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Control	000	2	2/28/2025	NON-COMPETING CONTINUATION	$804,229
														Subtotal = $1,428,173

Issue Date FY: 2024 ( Subtotal = $929,640 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Control	000	1	2/14/2024	NEW	$929,640
														Subtotal = $929,640

Grand Total All Awards = $3,143,258

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Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN)

Award Number: UG1CA286941

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/14/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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