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Northwestern Cancer Prevention Consortium

Award Number: UG1CA242643
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/03/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2031

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Northwestern Cancer Prevention Consortium - Northwestern University proposes to continue to lead a Network of organizations, known as the Northwestern Cancer Prevention Consortium (NCPC). We will design and conduct early phase clinical trials aimed at developing new options for cancer prevention. To date, 26 NCPC trials have accrued 1,052 participants (2003 cycle: 354, 2012 cycle: 463, 2019 to present: 235). These have targeted multiple organ sites using a variety of agents. We are currently testing innovative concepts (e.g. multivalent adenovirus vaccines for colon cancer prevention in Lynch syndrome) and are utilizing biomarkers such as breast density in novel ways (e.g., for dose optimization of tamoxifen in high-risk premenopausal women). Our proposal to renew the NCPC, under the continuing leadership of Seema A. Khan, MD includes current NCPC partners and new members who are expected to add important strengths in representation of groups spanning the national population (MUSC, Cook County Health, University of Puerto Rico) or genetic susceptibility (SickKids, UCSF). We will continue oversight, consultation, and administrative support to cancer prevention research teams and assist in the design, protocol development, and responsible conduct of cancer prevention trials. Our overarching goal is to continue our contributions to cancer prevention science through innovative, transformative, early phase trials testing new conceptual approaches to enable clinical advances in cancer prevention. Our Aims are to 1. Advance maximum impact priorities in cancer prevention toward clinical use. These priorities include (i) investigating novel and repurposed agents that target mutations and pathways of known importance in the cancer development, (ii) utilizing novel or established biomarkers to identify individuals most likely to benefit from a given approach, (iii) conducting trials that unify biological themes across different organ sites to protect against more than one cancer type, (iv) testing lower dosing approaches to reduce the toxicity burden of cancer prevention agents. 2. Provide consultation, scientific guidance, and mentoring to investigators who propose new trial concepts and provide assistance through trial design, initiation, conduct, and analysis; and to serve as the administrative hub of the Network. We will foster communication, collaboration, and sharing of available resources between Network members and across Networks to maximize the impact of clinical trials testing similar interventions or in similar populations. We will serve as a liaison between NCPC sites and the NCI/DCP 3. Advance cancer prevention science through evaluation and selection of innovative or transformative concepts that result in progress that is greater than the sum of knowledge gained from the specific goals of an individual trial. We will be guided in this process by an Advisory Board with strong background in cancer prevention research and by lay advocates to help us design and implement the most important clinical trial priorities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,870,000 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	002	8	8/12/2026	NON-COMPETING CONTINUATION	$1,870,000
2026	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	001	7	6/9/2026	COMPETING CONTINUATION	$0
2026	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	6	3/25/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,870,000

Issue Date FY: 2025 ( Subtotal = $1,870,000 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	001	7	8/5/2025	COMPETING CONTINUATION	$1,870,000
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	6	12/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,870,000

Issue Date FY: 2024 ( Subtotal = $983,603 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	6	9/5/2024	NON-COMPETING CONTINUATION	$983,603
														Subtotal = $983,603

Issue Date FY: 2023 ( Subtotal = $1,935,399 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	5	7/21/2023	NON-COMPETING CONTINUATION	$1,935,399
														Subtotal = $1,935,399

Issue Date FY: 2022 ( Subtotal = $298,222 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	4	8/18/2022	NON-COMPETING CONTINUATION	$298,222
														Subtotal = $298,222

Issue Date FY: 2021 ( Subtotal = $1,974,998 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	001	3	8/23/2021	NON-COMPETING CONTINUATION	$1,974,998
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	2	7/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,974,998

Issue Date FY: 2020 ( Subtotal = $1,974,998 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	2	8/31/2020	NON-COMPETING CONTINUATION	$1,974,998
														Subtotal = $1,974,998

Issue Date FY: 2019 ( Subtotal = $987,500 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Control	000	1	9/3/2019	NEW	$987,500
														Subtotal = $987,500

Grand Total All Awards = $11,894,720

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Northwestern Cancer Prevention Consortium

Award Number: UG1CA242643

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/03/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2031

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