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Combatting AntiMicrobial Resistance in Africa Using Data Science (CAMRA)

Award Number: U54TW012056
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Combatting AntiMicrobial Resistance in Africa Using Data Science (CAMRA) - Bacterial infections are highly prevalent and contribute significantly to morbidity and mortality across all age-groups but because appropriate microbiologic diagnostic services are non- existent or very limited, ascertaining the specific etiologic agents and the true prevalence of antimicrobial resistance (AMR) is a major challenge in Africa, where objective data is limited. Preliminary observations from Nigeria, the most populous country in Africa include the following; a) High prevalence of Salmonella enterica serovar Typhi (S. Typhi) with 45% prevalence of multidrug resistance, b) High prevalence of Extended Spectrum β-Lactamase- producing Enterobacteriaceae (ESBL-E) blood stream infections, c) Maternal colonization by ESBL-E in women at delivery is associated with high all-cause morbidity and mortality in their newborn babies compared to ESBL-unexposed babies and d) Periodic outbreaks of carbapenem-resistant Klebsiella pneumoniae sepsis in newborn units with case fatality rates as high as 45%. We have preliminary molecular characterization of about 500 of the 2,750 diverse bloodstream bacterial isolates in our collection. In addition, we have access to a collection of over 2,500 clinical isolates of blood, sputum and urine from our sentinel laboratories in Nigeria and Rwanda that are partially characterized. Our unique observations related to AMR genes that we have identified in our archived isolates form the basis for this research proposal. Our overall strategy in this application focuses on three thematic areas: 1). Comparative phenotypic and genotypic studies of archived and contemporary clinical isolates to inform trends in AMR and dynamics of transmission. 2) Incorporation of acute inflammatory markers of serious bacterial infection and gene products from resistant bacteria into a portable screening tool for clinical care and 3). Explore the potential benefit of an aminoglycoside (Tobramycin) conjugated to an antimicrobial peptide for enhanced bactericidal activity against multi-drug resistant enterobacteriales. We have assembled a multidisciplinary team of clinical and molecular microbiologists, clinicians, biomedical engineers, environmental microbiologists, veterinarians, and industrialists to implement this project in Nigeria, West Africa and also Rwanda, East Africa to provide data with geographic representation for Africa. Upon successful completion of this program, we would have utilized the data science platform for bacteria genomics and antimicrobial resistance to raise awareness on the scope of AMR in Africa, provide novel pathways for optimizing empiric use of antibiotics and trained a handful of young African scientists in bacterial genomics and bioinformatics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,264,691 )
2024	2024	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	001	4	8/6/2024	NON-COMPETING CONTINUATION	$1,264,691
2024	2023	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	000	3	2/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,264,691

Issue Date FY: 2023 ( Subtotal = $1,243,005 )
2023	2023	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	000	3	7/20/2023	NON-COMPETING CONTINUATION	$1,243,005
														Subtotal = $1,243,005

Issue Date FY: 2022 ( Subtotal = $1,198,845 )
2022	2022	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	000	2	6/29/2022	NON-COMPETING CONTINUATION	$1,198,845
														Subtotal = $1,198,845

Issue Date FY: 2021 ( Subtotal = $1,145,916 )
2021	2021	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	000	1	9/17/2021	NEW	$1,145,916
2021	2021	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	002	1	9/23/2021	NEW	$0
2021	2021	REDEEMER'S UNIVERSITY	KM 46 LAGOS-IBADAN EXPRESSWAY	REDEMPTION CITY				NGA	Trans-NIH Research Support	001	1	9/21/2021	NEW	$0
														Subtotal = $1,145,916

Grand Total All Awards = $4,852,457

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Combatting AntiMicrobial Resistance in Africa Using Data Science (CAMRA)

Award Number: U54TW012056

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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