Wednesday, July 2, 2025 7/2/2025

UAB Pilot Center for Precision Animal Modeling (C-PAM)

Award Number: U54OD030167
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

UAB Pilot Center for Precision Animal Modeling (C-PAM) - ABSTRACT (OVERALL) With the rapid increase in the number of potential variants being identified through whole genome sequencing technologies in patients with rare disorders, the challenge for geneticists is now to confirm that these variants are causative of the phenotype. This requires detailed assessment and annotation to separate the causative variant from those that are simple nonsignificant polymorphisms and sequencing or mapping errors. This is a complex problem to address requiring interdisciplinary approaches, detailed bioinformatic analysis, the generation of informative animal models, and a concerted effort to evaluate the variants. Accomplishing this goal is frequently beyond what an individual lab can easily or efficiently accomplish. In this regard, the Center for Clinical and Translational Science and the Precision Medicine Institute assembled a team of scientists and clinicians with expertise in basic research, computational and data sciences, human genetics, clinical diagnosis, and animal model generation to form the UAB Center for Precision Animal Modeling (C-PAM). The team has established a pipeline in which research and clinical community nominated variants will be thoroughly analyzed using an innovative bioinformatic toolkit generated by the C-PAM Bioinformatics Section. Selected variants will be modeled in animals by the C-PAM Disease Modeling Unit and the new models evaluated for human disease relevance by clinicians in the C-PAM Pre/Co-clinical Section. Once generated, C-PAM established collaborations will utilize the detailed informatic analyses and the animal resource that will be distributed through the C-PAM Resource and Services Section to advance our understanding of disease pathogenesis, to ascertain efficacy of novel or repurposed therapeutics, and to contribute to improved human health. C-PAM will leverage and organize our already existing expertise to fulfill our vision to become a national resource for efficient and cost-effective analysis of pathogenicity of gene variants identified in patients with rare disorders and to produce informative animal models to pursue disease mechanisms and targeted therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,856,249 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	5	8/15/2024	NON-COMPETING CONTINUATION	$1,856,249
														Subtotal = $1,856,249

Issue Date FY: 2023 ( Subtotal = $2,303,698 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	001	4	8/28/2023	NON-COMPETING CONTINUATION	$1,856,249
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	002	4	9/1/2023	SUPPLEMENT FOR EXPANSION	$447,449
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	3	8/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,303,698

Issue Date FY: 2022 ( Subtotal = $1,960,766 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	001	3	9/3/2022	SUPPLEMENT FOR EXPANSION	$104,517
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	3	8/25/2022	NON-COMPETING CONTINUATION	$1,856,249
														Subtotal = $1,960,766

Issue Date FY: 2021 ( Subtotal = $1,856,249 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	001	2	8/30/2021	NON-COMPETING CONTINUATION	$1,856,249
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	1	8/28/2021	NEW	$0
														Subtotal = $1,856,249

Issue Date FY: 2020 ( Subtotal = $1,856,249 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Infrastructure Programs	000	1	9/10/2020	NEW	$1,856,249
														Subtotal = $1,856,249

Grand Total All Awards = $9,833,211

Top

All Categories

About

Search

Reports

Data Submission

Award Information

UAB Pilot Center for Precision Animal Modeling (C-PAM)

Award Number: U54OD030167

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer