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TIGR/JTC LARGE SCALE SEQUENCING PRODUCTION CENTER

Award Number: U54HG003068
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/10/2003
PERIOD OF PERFORMANCE END DATE: 05/31/2008

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TIGR/JTC LARGE SCALE SEQUENCING PRODUCTION CENTER - DESCRIPTION (provided by applicant): The goals of the Large-Scale Genome Sequencing Production Center (Center) described in this application are to: (1) provide proven expertise in large-scale DNA sequencing and bioinformatics to the study of high priority eukaryotic species to consistently produce draft and finished genome sequences and annotation of the highest possible quality; (2) rapidly release genome sequence data, sequence traces, assemblies, and associated annotation to the public domain; (3) provide reagents and software developed under this grant to the scientific community; and (4) investigate and implement novel methods and technologies that can significantly increase sequencing throughput while decreasing sequencing costs. The Center will accomplish these goals through the application of a robust and sophisticated pipeline for large-scale genome sequencing and analysis that has been developed by a team of investigators that are world leaders in this field and have collectively sequenced more genomes than any other sequencing center. These include more than 40 microbial species, 13 parasitic and fungal pathogens, 2 plant species (Arabidopsis thaliana and rice), 2 insect species (Drosophila melanogaster and Anopheles gambiae), and 4 mammalian species (human, mouse, rat, and dog) to date, totaling more than 100 million sequencing reactions and over 10 billion base pairs of assembled genome sequence. Sequencing activities described in this application will be carried out at the newly created J. Craig Venter Science Foundation Joint Technology Center (JTC), a TIGR affiliate. The JTC laboratories have been designed to support high-throughput production pipelines for shotgun and BAC end sequencing projects and for PCR-based resequencing and SNP discovery at a level of 45 million sequencing reactions per year in its first year of operation. The JTC is designed to scale to over 120 million sequencing reactions per year. The initial per lane costs for the TIGR/JTC Sequencing Production Center are less than $0.94 and finishing costs are $.0.001 per basepair with significant reductions in the outlying years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2006	J CRAIG VENTER INSTITUTE INC	9704 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Human Genome Research	000	3	10/21/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2006 ( Subtotal = $9,852,999 )
2006	2006	J CRAIG VENTER INSTITUTE INC	9704 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Human Genome Research	001	3	9/28/2006	SUPPLEMENT FOR EXPANSION	$1,417,999
2006	2006	J CRAIG VENTER INSTITUTE INC	9704 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Human Genome Research	000	3	12/7/2005	NON-COMPETING CONTINUATION	$8,435,000
														Subtotal = $9,852,999

Issue Date FY: 2004 ( Subtotal = $10,500,000 )
2004	2004	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Human Genome Research	000	1	11/7/2003	NEW	$10,000,000
2004	2004	INSTITUTE FOR GENOMIC RESEARCH (THE)	9712 MEDICAL CENTER DRIVE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Human Genome Research	001	1	9/20/2004	SUPPLEMENT FOR EXPANSION	$500,000
														Subtotal = $10,500,000

Grand Total All Awards = $20,352,999

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TIGR/JTC LARGE SCALE SEQUENCING PRODUCTION CENTER

Award Number: U54HG003068

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/10/2003

PERIOD OF PERFORMANCE END DATE: 05/31/2008

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