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Boston Intellectual and Developmental Disabilities Research Center

Award Number: U54HD090255
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2021

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Boston Intellectual and Developmental Disabilities Research Center - ABSTRACT This Center grant requests funding for six core facilities; Administrative, Clinical/Translational, Cellular Imaging, Mouse Neurodevelopmental Behavior, Mouse Gene Manipulation and Molecular Genetics, to support a broadly-based research program in intellectual and developmental disabilities at Boston Children's Hospital and Harvard Medical School. Our specific aims are to: 1) Maintain and introduce new “state of the art” core facilities that can be shared by Intellectual and Developmental Disabilities Research Center (IDDRC) investigators, providing core research services not possible in a single laboratory; 2) Use the framework of the core laboratories to enhance and encourage collaboration between IDDRC investigators; 3) Provide core services to aid in the training of young investigators and trainees and 4) Use the core services provided by the IDDRC program to leverage collaboration outside the institution, particularly with other IDDRCs, to speed the development of effective clinical interventions in intellectual and developmental disabilities. The Center supports 105 research projects and 64 investigators who receive approximately $71M in external funding, $46M of which is from the NIH. Research in the Center occurs in over 125,000 sq.ft. of space in research buildings at Boston Children's Hospital and Harvard Medical School affiliated institutions in the Harvard Longwood Medical Area. Our research focuses on three programmatic areas- Basic Neuroscience, Clinical / Translational Neuroscience and Genetics- and our primary goal is to identify the causes of and develop therapies for children with intellectual and developmental disabilities. The research of this IDDRC encompasses laboratory research on fundamental processes of normal and abnormal neurodevelopment and plasticity, as well as clinical and behavioral studies directed at disorders including, but not limited to, autistic spectrum disorders, brain injury, neuro-oncology, learning and cognitive disabilities, the effects of surgery and environmental toxins on neural development, and multiple neurogenetic disorders, including those that affect neural formation, migration, specification and synaptic connectivity, as well as muscular dystrophy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$6,853 )
2022	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	5	11/10/2021	NON-COMPETING CONTINUATION	-$6,853
														Subtotal = -$6,853

Issue Date FY: 2020 ( Subtotal = $1,008,532 )
2020	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	5	7/7/2020	NON-COMPETING CONTINUATION	$1,008,532
2020	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	4	11/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,008,532

Issue Date FY: 2019 ( Subtotal = $1,008,532 )
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	4	8/26/2019	NON-COMPETING CONTINUATION	$1,008,532
2019	2018	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	11/14/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,008,532

Issue Date FY: 2018 ( Subtotal = $1,116,748 )
2018	2018	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	7/20/2018	NON-COMPETING CONTINUATION	$1,008,532
2018	2018	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	3	8/30/2018	SUPPLEMENT FOR EXPANSION	$108,216
														Subtotal = $1,116,748

Issue Date FY: 2017 ( Subtotal = $1,008,532 )
2017	2017	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	2	8/21/2017	NON-COMPETING CONTINUATION	$1,008,532
														Subtotal = $1,008,532

Issue Date FY: 2016 ( Subtotal = $1,008,532 )
2016	2016	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	9/22/2016	NEW	$1,008,532
														Subtotal = $1,008,532

Grand Total All Awards = $5,144,023

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Boston Intellectual and Developmental Disabilities Research Center

Award Number: U54HD090255

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2021

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