Friday, October 31, 2025 10/31/2025

Advance Clinical and Translational Research (Advance-CTR)

Award Number: U54GM115677
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Advance Clinical and Translational Research (Advance-CTR) - ABSTRACT – OVERALL The universities, hospitals, government agencies and community organizations in Rhode Island are well positioned to bridge the gaps between the worlds of clinical and basic science. Rhode Island’s small size, population demographics, and organizational structure are assets and present opportunities to implement and test transformative clinical and translational research. The health care delivery environment within the state is highly conducive to clinical research due to the relatively limited number of health care systems. Further contributing to Rhode Island’s translational research infrastructure are a number of well-organized Institutional Developmental Award (IDeA) Programs, each with core facility, faculty development and collaborative research resources. But despite Rhode Island’s impressive educational institutions, streamlined clinical environment, and successful IDeA sponsored research and mentoring programs, the majority of these resources have not been coordinately focused towards developing a multi-institutional, clinical and translational research infrastructure that would serve to improve the effectiveness of clinical practice and health care policy in Rhode Island. The objective of the Advance Clinical and Translation Research Award (Advance-CTR) is to bridge these infrastructure gaps by creating an overarching, multidisciplinary, central organization to better coordinate and leverage existing resources for program management and thereby provide the infrastructure necessary to address current and future health concerns in Rhode Island. The goals of the Advance-CTR are to: 1. Educate, mentor and encourage young investigators in clinical research professional development. 2. Eliminate the obstacles that may prevent researchers from pursuing clinical research initiatives that can lead to funded research programs. 3. Bring together clinical research resources to provide a virtual home that facilitates new collaborations and enhanced efficiencies. 4. Facilitate research to gather preliminary data necessary for developing competitive research proposals. 5. Provide contemporary infrastructure for clinical and translational research including research planning and implementation, advanced biostatistics and epidemiology support and biomedical informatics. 6. Foster coordination between translational researchers at our participating entities so as to create new productive collaborations with translational outcomes. 7. Sustain a clinical translational research environment by providing the necessary management and coordination of resources. 8. Create an innovative Tracking and Evaluation program that will combine support requests with use and cost data and apply lessons learned in the CTSA program to the CTR environment. SPECIFIC AIMS - OVERALL There is a tremendous opportunity for clinical and translational research discovery in Rhode Island. Although RI is the smallest state by land area, the population of over one million is larger than six other states and among the residents, 70 percent never leave the state. This translates not only into vibrant, tight-knit communities, but into a population that serves as an excellent testbed for longitudinal, community-engaged clinical and translational research. When Advance-CTR was funded in 2016 by an IDeA-CTR award from NIGMS, we entered a research partnership with established norms and protocols for conducting research within institutions, but not necessarily between institutions. With major healthcare systems and academic research institutions only a few miles apart, we had the unique opportunity to unify and synergize cross-institutional collaborations in ways that are less feasible in larger states. This has been a central goal in the first four years of our funding, an area where we have made tremendous progress, and an area where we continue to see opportunities. The infrastructure we have established has facilitated the transformation of clinical and t


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $4,139,256 )
2025	2025	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	10	9/16/2025	NON-COMPETING CONTINUATION	$4,139,256
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	9	10/24/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	9	10/23/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	9	10/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,139,256

Issue Date FY: 2024 ( Subtotal = $5,259,058 )
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	004	9	8/2/2024	SUPPLEMENT FOR EXPANSION	$805,599
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	005	9	8/28/2024	SUPPLEMENT FOR EXPANSION	$418,401
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	006	9	9/4/2024	SUPPLEMENT FOR EXPANSION	$336,344
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	9	7/29/2024	NON-COMPETING CONTINUATION	$3,979,264
2024	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	8	2/26/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	8	4/16/2024	NON-COMPETING CONTINUATION	$0
2024	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	7	6/21/2024	SUPPLEMENT FOR EXPANSION	-$280,550
														Subtotal = $5,259,058

Issue Date FY: 2023 ( Subtotal = $4,292,208 )
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	8	9/14/2023	NON-COMPETING CONTINUATION	$3,984,335
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	8	9/15/2023	SUPPLEMENT FOR EXPANSION	$307,873
2023	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	001	6	1/30/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	6	1/30/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,292,208

Issue Date FY: 2022 ( Subtotal = $5,779,513 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	008	7	8/29/2022	NON-COMPETING CONTINUATION	$3,988,693
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	009	7	9/8/2022	SUPPLEMENT FOR EXPANSION	$1,034,262
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	011	7	9/10/2022	SUPPLEMENT FOR EXPANSION	$797,476
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	6	2/1/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	005	6	8/26/2022	COMPETING CONTINUATION	$0
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	004	6	5/10/2022	COMPETING CONTINUATION	$2,985,150
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	006	6	8/26/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	6	2/1/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	007	6	8/26/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	5	12/8/2021	NON-COMPETING CONTINUATION	$0
2022	2020	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	010	5	9/8/2022	SUPPLEMENT FOR EXPANSION	-$40,918
2022	2020	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	5	5/10/2022	NON-COMPETING CONTINUATION	-$2,985,150
														Subtotal = $5,779,513

Issue Date FY: 2021 ( Subtotal = $4,451,325 )
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	007	6	9/13/2021	SUPPLEMENT FOR EXPANSION	$1,091,210
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	006	6	9/10/2021	SUPPLEMENT FOR EXPANSION	$297,938
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	008	6	9/14/2021	COMPETING CONTINUATION	$0
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	010	6	9/24/2021	COMPETING CONTINUATION	$661,216
2021	2021	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	005	6	9/7/2021	SUPPLEMENT FOR EXPANSION	$773,854
2021	2021	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	004	6	8/10/2021	COMPETING CONTINUATION	$1,607,815
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	001	5	1/1/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	5	8/9/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	000	5	12/11/2020	SUPPLEMENT FOR EXPANSION	$19,292
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	5	5/10/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	009	5	9/15/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,451,325

Issue Date FY: 2020 ( Subtotal = $4,843,998 )
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Trans-NIH Research Support	002	5	9/22/2020	SUPPLEMENT FOR EXPANSION	$880,348
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	5	5/6/2020	NON-COMPETING CONTINUATION	$3,963,650
2020	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	4	3/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,843,998

Issue Date FY: 2019 ( Subtotal = $4,326,862 ) (Continued on the next page)
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	4	8/29/2019	SUPPLEMENT FOR EXPANSION	$413,394
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	4	6/17/2019	NON-COMPETING CONTINUATION	$3,913,468
Grand Total All Awards = $44,703,203

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Advance Clinical and Translational Research (Advance-CTR)

Award Number: U54GM115677

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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