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Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)

Award Number: U54DK126114
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC) - Overall Project Summary In this application we establish the Maryland Polycystic Kidney Disease (PKD) Research and Translation Core Center (MPKD-RTCC). The mission of this Center is to facilitate translational and basic research in the field of polycystic kidney disease and related disciplines by providing unique resources, reagents and expertise to a broad base of investigators. This proposal capitalizes on a long tradition of PKD research by MPKD-RTCC investigators who have been at the forefront of PKD science for the past two decades. The Center consists of 4 highly collaborative and integrated biomedical research cores that together will distribute an essential “toolbox” of reagents and expertise tailored specifically to PKD research. The MPKD-RTCC cores include 1) Antibody and Vector 2) Mouse Models and Biobank 3) Cell Culture and Engineering and 4) Clinical and Translation. Each core addresses a critical need in the PKD research pipeline, stretching from basic to clinical investigation. In addition, MPKD-RTCC core leaders will pioneer solutions to perceived needs among PKD Researchers by expanding in innovative directions. We expect that this strategy will continue our proven track record of supporting high impact science across the country. These activities will be organized by an Administrative Core led by two experienced investigators who will leverage the resources of two outstanding research institutions in Baltimore, the University of Maryland Baltimore (UMB) and the Johns Hopkins School of Medicine. As a team they will drive the MPKD-RTCC’s fundamental commitment to the principle of collaborative science by streamlining SOPs for sharing high quality reagents and expertise, by integrating our the core’s activities and by coordinating collaboration with other RTCCs within the PKD Research Consortium. The Center’s Specific Aims are: 1) To provide critical state of the art reagents and expertise to a national group of PKD investigators 2) To provide critical state of the art reagents and expertise to non-PKD investigators in order to remove barriers to PKD related research 3) To develop innovative reagents and resources that will advance biomedical discoveries in the field of PKD 4) To drive collaboration between MPKD-RTCC Cores and other RTCCs within the PKD Research Consortium and 5) To partner with other RTCCs, the consortium steering committee including the NIDDK to achieve the overall goals of the PKD Research Consortium. Through expanded interdisciplinary collaborations, we hope to catalyze the translation of biomedical discoveries that will prevent progression of polycystic kidney disease and its consequences.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $887,608 )
2024	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/2/2024	NON-COMPETING CONTINUATION	$887,608
2024	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	8/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $887,608

Issue Date FY: 2023 ( Subtotal = $950,475 )
2023	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/11/2023	NON-COMPETING CONTINUATION	$884,264
2023	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	8/21/2023	SUPPLEMENT FOR EXPANSION	$66,211
														Subtotal = $950,475

Issue Date FY: 2022 ( Subtotal = $945,142 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	9/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/30/2022	NON-COMPETING CONTINUATION	$888,392
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	9/12/2022	SUPPLEMENT FOR EXPANSION	$56,750
														Subtotal = $945,142

Issue Date FY: 2021 ( Subtotal = $917,993 )
2021	2021	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/23/2021	NON-COMPETING CONTINUATION	$917,993
														Subtotal = $917,993

Issue Date FY: 2020 ( Subtotal = $919,652 )
2020	2020	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/6/2020	NEW	$919,652
														Subtotal = $919,652

Grand Total All Awards = $4,620,870

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Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)

Award Number: U54DK126114

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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