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Center for Genome Interpretation

Award Number: U54DK105566
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2019

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Center for Genome Interpretation - DESCRIPTION (provided by applicant): We propose to create new infrastructure and methods for genomic analysis and apply these to large, complex datasets for type 2 diabetes (T2D), a leading cause of morbidity and mortality that is driven by diverse genetic and environmental factors. This proposal has three primary scientific goals. (1) We will develop infrastructure and analytical tools to harmonize heterogeneous genomic datasets ascertained for the study of complex disease, as demonstrated on DNA sequencing data from over 50,000 individuals; (2) we will design statistical frameworks to identify functional mutations in T2D and analyze their biological consequences, taking advantage of existing data and resources on genetic variation, transcription, and epigenetics; and finally (3) we will democratize access to genomic data by creating user-friendly portals with automated analytical pipelines and intuitive features for data exploration. The software, methods, and web portals we build will help overcome the barriers that currently inhibit the translation of genomic data into biological knowledge and therapeutic insights for T2D.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$26,420 )
2023	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	10/1/2022	SUPPLEMENT FOR EXPANSION	-$26,420
														Subtotal = -$26,420

Issue Date FY: 2017 ( Subtotal = $2,509,533 )
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/4/2017	NON-COMPETING CONTINUATION	$2,014,022
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/6/2017	SUPPLEMENT FOR EXPANSION	$495,511
														Subtotal = $2,509,533

Issue Date FY: 2016 ( Subtotal = $2,014,022 )
2016	2016	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/12/2016	NON-COMPETING CONTINUATION	$2,014,022
														Subtotal = $2,014,022

Issue Date FY: 2015 ( Subtotal = $2,014,022 )
2015	2015	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/11/2015	NON-COMPETING CONTINUATION	$2,014,022
														Subtotal = $2,014,022

Issue Date FY: 2014 ( Subtotal = $2,033,272 )
2014	2014	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/23/2014	NEW	$2,033,272
														Subtotal = $2,033,272

Grand Total All Awards = $8,544,429

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Center for Genome Interpretation

Award Number: U54DK105566

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2019

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