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 | Issue Date FY: 2026 ( Subtotal = $16,483,337 ) (Continued on the next page) |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 2 | NIH | 1/28/2026 | $129,410 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DE035622 | Computational methods for benchmarking and development of best practices for virus discovery and characterization in the HVP consortium | 000 | 1 | NIH | 3/13/2026 | $1 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011450 | The Genome Aggregation Database (gnomAD) | 003 | 6 | NIH | 4/7/2026 | $9,863,035 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 9 | NIH | 3/23/2026 | $63,674 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS132022 | Biomarkers and Mechanisms of PrP Misfolding, Mutation, and Deficiency | 000 | 3 | NIH | 3/23/2026 | $648,225 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 4 | NIH | 3/23/2026 | $420,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012781 | Improving Genetic Diagnosis for African Ancestry Populations | 000 | 3 | NIH | 1/22/2026 | $590,637 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00CA264422 | A visible machine learning system to discover targeted treatment solutions in cancer | 000 | 6 | NIH | 2/27/2026 | $105,108 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 001 | 5 | NIH | 2/26/2026 | $52,929 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K25AI168451 | Physical Biology and Deep Learning for Antibiotic Resistance and Discovery | 000 | 5 | NIH | 1/13/2026 | $125,706 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 5 | NIH | 12/23/2025 | $392,517 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 000 | 4 | NIH | 1/6/2026 | $629,655 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 2 | NIH | 12/18/2025 | $722,218 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 5 | NIH | 12/12/2025 | $476,359 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA271719 | Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation | 000 | 3 | NIH | 2/12/2026 | $80,224 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 2 | NIH | 2/9/2026 | $777,944 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DE035622 | Computational methods for benchmarking and development of best practices for virus discovery and characterization in the HVP consortium | 000 | 1 | NIH | 3/13/2026 | $563,428 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 9 | NIH | 1/29/2026 | $573,066 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19NS132315 | Therapeutic Editing to Lower PrP in Prion Disease | 000 | 3 | NIH | 3/13/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011450 | The Genome Aggregation Database (gnomAD) | 002 | 5 | NIH | 4/2/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 000 | 3 | NIH | 4/1/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24NS132940 | An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP) | 000 | 3 | NIH | 4/1/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24NS132940 | An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP) | 000 | 3 | NIH | 4/1/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 3/26/2026 | -$246 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00DK123834 | NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis | 000 | 6 | NIH | 3/25/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 001 | 4 | NIH | 2/26/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 001 | 4 | NIH | 2/26/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 001 | 11 | NIH | 3/2/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011450 | The Genome Aggregation Database (gnomAD) | 000 | 5 | NIH | 1/14/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 000 | 4 | NIH | 1/15/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DK105554 | The next iteration of the AMP-T2D Knowledge Portal | 000 | 10 | NIH | 12/19/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 000 | 8 | NIH | 11/20/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 001 | 6 | NIH | 12/18/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 11 | NIH | 10/1/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 000 | 5 | NIH | 12/22/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 000 | 6 | NIH | 11/21/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA264024 | Comprehensive analysis of point mutations in cancer | 000 | 5 | NIH | 2/12/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013986 | Advancing rare disease discovery through technological and methodological approaches using an intuitive platform, seqr | 000 | 1 | NIH | 12/11/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011450 | The Genome Aggregation Database (gnomAD) | 001 | 5 | NIH | 2/5/2026 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21CA299494 | Methods for profiling the cancer virome and microbial strain genetics | 001 | 2 | NIH | 1/27/2026 | $397,771 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DA053631 | Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV | 000 | 5 | NIH | 1/30/2026 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99HL169733 | Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease | 001 | 2 | NIH | 3/25/2026 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA284834 | Identifying genetic vulnerabilities in KIAA1549-BRAF mutant pediatric low-grade gliomas | 001 | 2 | NIH | 3/24/2026 | -$3,839 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 12/23/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 12/23/2025 | $0 |
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