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 | Issue Date FY: 2026 ( Subtotal = $1,512,143 ) |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 5 | NIH | 12/23/2025 | $392,517 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 5 | NIH | 12/12/2025 | $476,359 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 2 | NIH | 12/18/2025 | $722,218 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DK105554 | The next iteration of the AMP-T2D Knowledge Portal | 000 | 10 | NIH | 12/19/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 000 | 8 | NIH | 11/20/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 5 | NIH | 12/10/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 001 | 6 | NIH | 12/18/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 000 | 6 | NIH | 11/21/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 000 | 5 | NIH | 12/22/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 11 | NIH | 10/1/2025 | $0 |
| | 2026 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013986 | Advancing rare disease discovery through technological and methodological approaches using an intuitive platform, seqr | 000 | 1 | NIH | 12/11/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3CA239105 | Assay Validation of Cell-Free DNA Shallow Whole Genome Sequencing To Determine 'Tumor Fraction' in Advanced Cancers | 000 | 5 | NIH | 12/22/2025 | -$75,474 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3MH120096 | Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species. | 000 | 5 | NIH | 11/27/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA248455 | Advanced development of the Cancer Dependency Map portal (DepMap.org) | 000 | 5 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99HL169733 | Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease | 000 | 2 | NIH | 12/8/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 11/21/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 12/23/2025 | $0 |
| | 2026 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 12/23/2025 | $0 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R03OD036495 | High-throughput Discovery of Novel Genome Organization Regulators | 000 | 1 | NIH | 12/22/2025 | $0 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R03TR004561 | Establishing foundational tools and datasets for investigation of NSD1 gene function in neural development | 000 | 1 | NIH | 12/12/2025 | $0 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21MH126374 | Gene expression changes during postnatal development of the marmoset, mouse, and human brain: a pilot study with focus on prefrontal cortex,adolescence, and psychiatric risk genetics | 000 | 2 | NIH | 12/5/2025 | -$2,494 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH131719 | Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep Spindle | 000 | 2 | NIH | 12/15/2025 | $0 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH131719 | Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep Spindle | 000 | 2 | NIH | 12/15/2025 | $0 |
| | 2026 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA233626 | The function of the PRMT5 methylosome in MTAP deleted cancers | 000 | 5 | NIH | 11/20/2025 | $0 |
| | 2026 | 2022 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL143295 | Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts | 000 | 4 | NIH | 12/29/2025 | -$983 |
| | 2026 | 2022 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP2MH132942 | High-throughput methods for measuring cortical synaptic connectivity at single-cell resolution | 000 | 1 | NIH | 12/29/2025 | $0 |
|
| Issue Date FY: 2025 ( Subtotal = $129,533,881 ) (Continued on the next page) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA264029 | Center for the Comprehensive Analysis of Cancer Somatic Copy-Number Alterations, Rearrangements, and Long-Read Sequencing Data | 000 | 5 | NIH | 8/28/2025 | $397,265 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 000 | 5 | NIH | 4/18/2025 | $357,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 001 | 5 | NIH | 9/23/2025 | $63,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 000 | 6 | NIH | 8/18/2025 | $3,418,624 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35CA242457 | Making cancer precision medicine real: bottlenecks and opportunities | 000 | 7 | NIH | 7/17/2025 | $1,023,754 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI158495 | Factors regulating strength and duration of STING signaling | 000 | 5 | NIH | 8/11/2025 | $423,643 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $322,826 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $150,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $8,872 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 3/26/2025 | $100,000 |
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