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 | Issue Date FY: 2025 ( Subtotal = $129,533,881 ) (Continued on the next page) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA264029 | Center for the Comprehensive Analysis of Cancer Somatic Copy-Number Alterations, Rearrangements, and Long-Read Sequencing Data | 000 | 5 | NIH | 8/28/2025 | $397,265 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 000 | 5 | NIH | 4/18/2025 | $357,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 001 | 5 | NIH | 9/23/2025 | $63,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U2CCA252974 | Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults | 000 | 6 | NIH | 8/18/2025 | $3,418,624 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35CA242457 | Making cancer precision medicine real: bottlenecks and opportunities | 000 | 7 | NIH | 7/17/2025 | $1,023,754 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI158495 | Factors regulating strength and duration of STING signaling | 000 | 5 | NIH | 8/11/2025 | $423,643 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $322,826 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $150,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $8,872 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 3/26/2025 | $100,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA233626 | The function of the PRMT5 methylosome in MTAP deleted cancers | 000 | 6 | NIH | 9/17/2025 | $472,119 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH115957 | Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum | 000 | 7 | NIH | 4/14/2025 | $646,266 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 002 | 8 | NIH | 9/8/2025 | $3,430,005 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 8 | NIH | 1/13/2025 | $573,066 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 002 | 8 | NIH | 8/12/2025 | $63,674 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 001 | 11 | NIH | 4/11/2025 | $635,211 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 002 | 11 | NIH | 7/8/2025 | $565,177 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 000 | 1 | NIH | 1/17/2025 | $4,000,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 1 | NIH | 1/24/2025 | $143,788 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 001 | 1 | NIH | 4/23/2025 | $74,344 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 1 | NIH | 1/8/2025 | $650,625 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 1 | NIH | 1/3/2025 | $817,208 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 001 | 3 | NIH | 6/11/2025 | $3,080,661 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 001 | 4 | NIH | 7/1/2025 | $100,863 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 000 | 4 | NIH | 3/28/2025 | $907,766 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG006834 | Broad-Geisinger Clinical Genome Resource | 001 | 12 | NIH | 9/18/2025 | $4,353,875 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 001 | 5 | NIH | 8/11/2025 | $18,800 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 4 | NIH | 11/27/2024 | $479,978 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 11/27/2024 | $211,504 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DK137242 | Development of platforms for beta cell-specific delivery and ligand discovery | 001 | 3 | NIH | 6/3/2025 | $931,590 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1MH130966 | An Atlas of Human Brain Cell Variation | 000 | 4 | NIH | 8/5/2025 | $13,648,736 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 001 | 1 | NIH | 5/5/2025 | $518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 000 | 1 | NIH | 3/21/2025 | $518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 001 | 1 | NIH | 5/5/2025 | -$518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R33CA291199 | A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis | 000 | 2 | NIH | 8/11/2025 | $413,641 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 001 | 2 | NIH | 7/3/2025 | $0 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 000 | 2 | NIH | 6/25/2025 | $723,408 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 000 | 2 | NIH | 6/25/2025 | $1,130,403 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21AI178690 | Development of phosphorylation editing chimeras using kinase inhibitors | 000 | 2 | NIH | 5/16/2025 | $210,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA271719 | Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation | 001 | 2 | NIH | 5/22/2025 | $1,284 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA271719 | Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation | 000 | 2 | NIH | 3/10/2025 | $76,756 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61CA278536 | Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq | 001 | 2 | NIH | 5/30/2025 | $20,695 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F31DK136312 | Mechanisms of Renal Lipotoxicity | 000 | 2 | NIH | 5/30/2025 | $43,138 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61CA278536 | Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq | 000 | 2 | NIH | 4/7/2025 | $186,260 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK132900 | Development of platforms for sorting, production, editing of beta cells | 000 | 3 | NIH | 4/25/2025 | $651,811 |
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