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 | Issue Date FY: 2025 ( Subtotal = $88,342,468 ) (Continued on the next page) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32AI179151 | Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis | 000 | 2 | NIH | 4/16/2025 | $79,282 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 4 | NIH | 1/14/2025 | $340,185 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | RC2DK135492 | Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies | 000 | 3 | NIH | 7/25/2025 | $2,017,193 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012467 | Cross-platform structural variant discovery with deep learning | 000 | 4 | NIH | 7/31/2025 | $575,926 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL164811 | High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes | 000 | 3 | NIH | 6/19/2025 | $665,483 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 3 | NIH | 3/20/2025 | $378,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS132022 | Biomarkers and Mechanisms of PrP Misfolding, Mutation, and Deficiency | 000 | 2 | NIH | 3/4/2025 | $585,539 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA266642 | Development of p300/CBP histone acetyltransferase inhibitors for oncogene-driven cancers | 000 | 4 | NIH | 5/21/2025 | $657,156 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 002 | 4 | NIH | 6/12/2025 | $1,088,025 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH128366 | Unraveling the Genetic Programs Engaged in ASD Neurons Through Coupled Transcriptomic and Phenotypic Readouts | 000 | 4 | NIH | 7/8/2025 | $738,884 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00DK123834 | NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis | 000 | 6 | NIH | 2/17/2025 | $98,177 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 001 | 3 | NIH | 6/25/2025 | $400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 000 | 3 | NIH | 5/7/2025 | $620,313 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 000 | 5 | NIH | 4/18/2025 | $357,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35CA242457 | Making cancer precision medicine real: bottlenecks and opportunities | 000 | 7 | NIH | 7/17/2025 | $1,023,754 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI158495 | Factors regulating strength and duration of STING signaling | 000 | 5 | NIH | 8/11/2025 | $423,643 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $150,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $8,872 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $322,826 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 3/26/2025 | $100,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 003 | 5 | NIH | 4/29/2025 | $29,400 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH115957 | Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum | 000 | 7 | NIH | 4/14/2025 | $646,266 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 001 | 11 | NIH | 4/11/2025 | $635,211 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 002 | 11 | NIH | 7/8/2025 | $565,177 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 1 | NIH | 1/24/2025 | $143,788 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 000 | 1 | NIH | 1/17/2025 | $4,000,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 001 | 1 | NIH | 4/23/2025 | $74,344 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 1 | NIH | 1/8/2025 | $650,625 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 002 | 8 | NIH | 8/12/2025 | $63,674 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 8 | NIH | 1/13/2025 | $573,066 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 1 | NIH | 1/3/2025 | $817,208 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 001 | 4 | NIH | 7/1/2025 | $100,863 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 000 | 4 | NIH | 3/28/2025 | $907,766 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 001 | 3 | NIH | 6/11/2025 | $3,080,661 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 001 | 5 | NIH | 8/11/2025 | $18,800 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 11/27/2024 | $211,504 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 4 | NIH | 11/27/2024 | $479,978 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DK137242 | Development of platforms for beta cell-specific delivery and ligand discovery | 001 | 3 | NIH | 6/3/2025 | $931,590 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1MH130966 | An Atlas of Human Brain Cell Variation | 000 | 4 | NIH | 8/5/2025 | $13,648,736 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 001 | 1 | NIH | 5/5/2025 | -$518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 001 | 1 | NIH | 5/5/2025 | $518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 000 | 1 | NIH | 3/21/2025 | $518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R33CA291199 | A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis | 000 | 2 | NIH | 8/11/2025 | $413,641 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 001 | 2 | NIH | 7/3/2025 | $0 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 000 | 2 | NIH | 6/25/2025 | $723,408 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 000 | 2 | NIH | 6/25/2025 | $1,130,403 |
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