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 | Issue Date FY: 2025 ( Subtotal = $13,002,827 ) (Continued on the next page) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 1 | NIH | 1/3/2025 | $817,208 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS132022 | Biomarkers and Mechanisms of PrP Misfolding, Mutation, and Deficiency | 000 | 2 | NIH | 3/4/2025 | $585,539 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA271719 | Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation | 000 | 2 | NIH | 3/10/2025 | $76,756 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00DK123834 | NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis | 000 | 6 | NIH | 2/17/2025 | $98,177 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 000 | 1 | NIH | 3/21/2025 | $518,670 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $264,600 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 5 | NIH | 2/18/2025 | $322,826 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 3/26/2025 | $100,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 3 | NIH | 3/20/2025 | $378,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 000 | 4 | NIH | 3/28/2025 | $907,766 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 1 | NIH | 1/8/2025 | $650,625 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 000 | 3 | NIH | 1/15/2025 | $629,655 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 4 | NIH | 1/14/2025 | $340,185 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 8 | NIH | 1/13/2025 | $573,066 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 4 | NIH | 11/27/2024 | $479,978 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K25AI168451 | Physical Biology and Deep Learning for Antibiotic Resistance and Discovery | 000 | 4 | NIH | 12/5/2024 | $125,706 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DK105554 | The next iteration of the AMP-T2D Knowledge Portal | 000 | 10 | NIH | 12/17/2024 | $3,197,364 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99HL177340 | Integration of novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adults | 000 | 1 | NIH | 1/31/2025 | $165,364 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 11/27/2024 | $211,504 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 1 | NIH | 1/24/2025 | $143,788 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 000 | 1 | NIH | 1/17/2025 | $4,000,000 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00CA264422 | A visible machine learning system to discover targeted treatment solutions in cancer | 000 | 5 | NIH | 2/14/2025 | $100,527 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS132994 | Regulatory Consulting to Support Advancement of a Divalent siRNA for Prion Disease | 000 | 2 | NIH | 12/3/2024 | $98,280 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH130675 | 1/4 Asian Bipolar Genetics Network (A-BIG-NET) | 000 | 3 | NIH | 3/24/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DK137242 | Development of platforms for beta cell-specific delivery and ligand discovery | 000 | 2 | NIH | 2/21/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HD090743 | GMKF competing renewal | 000 | 9 | NIH | 2/17/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24DK112340 | A biochemical roadmap of exercise signal | 003 | 7 | NIH | 2/19/2025 | $3,702,662 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD038121 | Broad-Color: The Genome Center for the Future of All of Us | 000 | 1 | NIH | 3/13/2025 | $454,136 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 001 | 10 | NIH | 3/18/2025 | $94,959 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA287069 | A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy | 000 | 1 | NIH | 3/20/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP2GM146252 | Optical Functional Genomics | 001 | 2 | NIH | 2/13/2025 | $222,014 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA277583 | AI-Powered Uncovering of Mechanisms in Cancer Through Causal Discovery Analysis and Generative Modeling of Heterogeneous Data | 000 | 2 | NIH | 2/12/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00AG068523 | Function of reactive astrocytes in aging and neurodegenerative disease | 001 | 5 | NIH | 1/15/2025 | $85,747 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA271075 | Center for comprehensive proteogenomic data analysis | 000 | 3 | NIH | 1/6/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 001 | 3 | NIH | 1/21/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 10 | NIH | 11/20/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19NS132315 | Therapeutic Editing to Lower PrP in Prion Disease | 000 | 2 | NIH | 11/20/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 000 | 2 | NIH | 12/18/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 000 | 3 | NIH | 11/18/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 003 | 11 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01GM137606 | Chemical approaches for precision genome editing | 000 | 4 | NIH | 12/19/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 001 | 11 | NIH | 10/21/2024 | $2,116,779 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG006834 | Broad-Geisinger Clinical Genome Resource | 000 | 11 | NIH | 12/6/2024 | $0 |
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