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 | Issue Date FY: 2025 ( Subtotal = $223,477 ) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 11/27/2024 | $211,504 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 4 | NIH | 11/27/2024 | $479,978 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 000 | 3 | NIH | 11/18/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 10 | NIH | 11/20/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 7 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 000 | 4 | NIH | 10/9/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 003 | 11 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 001 | 11 | NIH | 10/21/2024 | $2,116,779 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 000 | 7 | NIH | 10/9/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19NS132315 | Therapeutic Editing to Lower PrP in Prion Disease | 000 | 2 | NIH | 11/20/2024 | $0 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms Promoting Copper Dependent Cell Death in Cancer | 000 | 1 | NIH | 11/25/2024 | -$444,739 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH131719 | Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep Spindle | 000 | 2 | NIH | 11/20/2024 | $0 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | S10MH133644 | SyncroPatch 384 Automated Patch Clamp Instrument | 000 | 1 | NIH | 10/28/2024 | -$39 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 000 | 10 | NIH | 10/21/2024 | -$2,116,779 |
| | 2025 | 2022 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD101534 | Delineating a role for histone modifications in Down syndrome using human cellular models | 001 | 1 | NIH | 10/9/2024 | $0 |
| | 2025 | 2021 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24DK110499 | A comprehensive platform for novel therapy development from the microbiome | 000 | 5 | NIH | 11/13/2024 | $0 |
| | 2025 | 2021 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 002 | 8 | NIH | 10/24/2024 | -$23,227 |
| | 2025 | 2020 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD101534 | Delineating a role for histone modifications in Down syndrome using human cellular models | 000 | 1 | NIH | 10/9/2024 | $0 |
|
| Issue Date FY: 2024 ( Subtotal = $154,001,632 ) (Continued on the next page) |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Exploration and benchmarking of duplex sequencing | 001 | 2 | NIH | 8/29/2024 | $88,916 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99HL165024 | Using genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery disease | 000 | 2 | NIH | 6/27/2024 | $166,860 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK129464 | Interrogating the ubiquitin pathway to understand and treat cytokine-induced beta-cell death in type 1 diabetes | 000 | 4 | NIH | 6/27/2024 | $512,291 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R25HG006682 | Promoting Diversity, Equity, Inclusion, and Belonging in Genomic Research. | 000 | 12 | NIH | 6/12/2024 | $128,719 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI153405 | Rapid fungal identification and antifungal susceptibility testing through quantitative, multiplexed RNA detection | 000 | 5 | NIH | 6/12/2024 | $652,802 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 001 | 3 | NIH | 7/30/2024 | $65,665 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA284834 | Identifying genetic vulnerabilities in KIAA1549-BRAF mutant pediatric low-grade gliomas | 000 | 2 | NIH | 8/14/2024 | $78,892 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R03CA293115 | Activation of SLFN12 RNase Activity by Dimerization | 000 | 1 | NIH | 8/14/2024 | $154,400 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01MH125047 | 1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries | 000 | 5 | NIH | 8/15/2024 | $939,577 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01MH125047 | 1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries | 000 | 5 | NIH | 8/15/2024 | $3,251,068 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 001 | 3 | NIH | 8/15/2024 | $25,080 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99GM155595 | Factors Shaping the Genomic Spectrum of Structural Variants | 000 | 1 | NIH | 8/8/2024 | $125,000 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP2GM146245 | Single-cell in situ analysis of RNA modifications in intact tissues | 000 | 2 | NIH | 8/23/2024 | $1,008,000 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 8/12/2024 | $1 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 8/12/2024 | $367,039 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS132994 | Advancement of Prion Protein-Lowering Divalent siRNA Therapy for Prion Disease | 000 | 2 | NIH | 8/12/2024 | $806,536 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI158495 | Factors regulating strength and duration of STING signaling | 000 | 4 | NIH | 8/9/2024 | $423,643 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms Promoting Copper Dependent Cell Death in Cancer | 002 | 1 | NIH | 6/21/2024 | -$31,002 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH127085 | Characterization of structure-function relationships in distinct thalamic reticular nucleus networks | 000 | 4 | NIH | 7/1/2024 | $420,000 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 001 | 3 | NIH | 6/17/2024 | $1,019,814 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1MH130966 | An Atlas of Human Brain Cell Variation | 001 | 3 | NIH | 8/8/2024 | $516,308 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01GM137606 | Chemical approaches for precision genome editing | 001 | 4 | NIH | 8/5/2024 | $36,263 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24DK112340 | A biochemical roadmap of exercise signal | 002 | 7 | NIH | 8/7/2024 | $1 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG012090 | Developmental GTEx Laboratory, Data Analysis and Coordination Center | 000 | 4 | NIH | 7/22/2024 | $3,095,834 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61CA281807 | Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries | 000 | 2 | NIH | 7/12/2024 | $210,516 |
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