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 | Issue Date FY: 2026 ( Subtotal = $78,232,732 ) (Continued on the next page) |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99AI200707 | Directing the Evolution of Common Human Precursors into HIV-1 Broadly Neutralizing Antibodies | 000 | 1 | NIH | 6/12/2026 | $165,269 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61CA309784 | Expanding targetable space of extracellular therapeutic modalities using intracellular proteins | 000 | 1 | NIH | 6/23/2026 | $245,297 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | AY2AX000212 | Pediatric Epilepsies & Rare CNS (PERC) Gene Editing Platform | 000 | 1 | NIH | 7/6/2026 | $6,509,921 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21TR006289 | Rapid drug repurposing for rare disorders by pooled image-based profiling | 000 | 1 | NIH | 4/27/2026 | $436,250 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61NS146351 | Engineering TfR1 binding CNS targeted AAV capsids that evade pre-existing neutralizing antibodies | 000 | 1 | NIH | 4/21/2026 | $404,282 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DE035622 | Computational methods for benchmarking and development of best practices for virus discovery and characterization in the HVP consortium | 000 | 1 | NIH | 3/13/2026 | $1 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DE035622 | Computational methods for benchmarking and development of best practices for virus discovery and characterization in the HVP consortium | 000 | 1 | NIH | 3/13/2026 | $563,428 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01MH142288 | Using Enhancer-directed expression within AAVs to target subtypes within the four major neuromodulatory populations | 000 | 1 | NIH | 6/16/2026 | $3,312,425 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19NS132315 | Therapeutic Editing to Lower PrP in Prion Disease | 002 | 4 | NIH | 6/30/2026 | $11,321,612 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32NS148600 | Non-Autonomous Regulation of Interneuron Fate, Position, and Survival by Excitatory Neurons during Cortical Development | 000 | 1 | NIH | 5/5/2026 | $76,780 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AG095944 | Genetic dissection of mitonuclear interactions in aging and neurodegenerative disease | 000 | 2 | NIH | 6/3/2026 | $610,836 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24DK112340 | A biochemical roadmap of exercise signal | 000 | 8 | NIH | 6/12/2026 | $198,001 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 4 | NIH | 3/23/2026 | $420,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS132022 | Biomarkers and Mechanisms of PrP Misfolding, Mutation, and Deficiency | 000 | 3 | NIH | 3/23/2026 | $648,225 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99HL177340 | Integration of novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adults | 000 | 2 | NIH | 4/27/2026 | $165,364 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00CA264422 | A visible machine learning system to discover targeted treatment solutions in cancer | 000 | 6 | NIH | 2/27/2026 | $105,108 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011723 | Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries | 001 | 5 | NIH | 6/30/2026 | $875,671 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 002 | 5 | NIH | 5/13/2026 | $2,348,207 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2CA297578 | PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors | 001 | 1 | NIH | 6/3/2026 | $778,290 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K25AI168451 | Physical Biology and Deep Learning for Antibiotic Resistance and Discovery | 000 | 5 | NIH | 1/13/2026 | $125,706 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA271075 | Center for comprehensive proteogenomic data analysis | 000 | 5 | NIH | 6/25/2026 | $788,387 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R37MH107649 | Statistical methods to localize disease heritability and identify biological mechanisms | 000 | 12 | NIH | 6/25/2026 | $811,795 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012781 | Improving Genetic Diagnosis for African Ancestry Populations | 000 | 3 | NIH | 1/22/2026 | $590,637 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | RC2DK135492 | Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies | 000 | 4 | NIH | 5/26/2026 | $2,010,473 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD036440 | The Common Fund Knowledge Center (CFKC): providing scientifically valid knowledge from the Common Fund Data Ecosystem to the biomedical research community | 000 | 1 | NIH | 6/15/2026 | $420,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 5 | NIH | 12/23/2025 | $392,517 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD111876 | Investigating epigenetic mechanisms in Down syndrome using human cellular models | 001 | 2 | NIH | 5/26/2026 | $707,150 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL164811 | High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes | 000 | 4 | NIH | 5/4/2026 | $656,770 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 000 | 5 | NIH | 6/23/2026 | $1,087,619 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 001 | 4 | NIH | 4/20/2026 | $69,961 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 000 | 4 | NIH | 1/6/2026 | $629,655 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 001 | 4 | NIH | 4/17/2026 | $610,231 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00NS125829 | The impact of mitochondrial and peroxisomal fission dynamics on metabolic signaling during corticogenesis. | 000 | 5 | NIH | 5/12/2026 | $95,667 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $400,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $250,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $654,520 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA233626 | The function of the PRMT5 methylosome in MTAP deleted cancers | 001 | 7 | NIH | 6/19/2026 | $453,369 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 9 | NIH | 3/23/2026 | $63,674 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 9 | NIH | 1/29/2026 | $573,066 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 001 | 9 | NIH | 6/30/2026 | $3,430,001 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 000 | 12 | NIH | 4/9/2026 | $565,177 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 001 | 2 | NIH | 4/17/2026 | $14,378 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 2 | NIH | 1/28/2026 | $129,410 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 001 | 2 | NIH | 6/16/2026 | $0 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 000 | 2 | NIH | 5/1/2026 | $4,060,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 2 | NIH | 12/18/2025 | $722,218 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 001 | 2 | NIH | 4/27/2026 | $24,567 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 2 | NIH | 2/9/2026 | $777,944 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 001 | 4 | NIH | 5/13/2026 | $6,923,415 |
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