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 | Issue Date FY: 2026 ( Subtotal = $135,670,509 ) (Continued on the next page) |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012781 | Improving Genetic Diagnosis for African Ancestry Populations | 000 | 3 | NIH | 1/22/2026 | $590,637 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00NS125829 | The impact of mitochondrial and peroxisomal fission dynamics on metabolic signaling during corticogenesis. | 000 | 5 | NIH | 5/12/2026 | $95,667 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 001 | 4 | NIH | 4/20/2026 | $69,961 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 000 | 4 | NIH | 1/6/2026 | $629,655 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32AI179151 | Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis | 000 | 2 | NIH | 7/9/2026 | $3,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 5 | NIH | 12/23/2025 | $392,517 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD036440 | The Common Fund Knowledge Center (CFKC): providing scientifically valid knowledge from the Common Fund Data Ecosystem to the biomedical research community | 002 | 1 | NIH | 8/7/2026 | $124,425 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD036440 | The Common Fund Knowledge Center (CFKC): providing scientifically valid knowledge from the Common Fund Data Ecosystem to the biomedical research community | 000 | 1 | NIH | 6/15/2026 | $420,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | RC2DK135492 | Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologies | 000 | 4 | NIH | 5/26/2026 | $2,010,473 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH134468 | Genetics of PTSD in African Ancestry Populations | 000 | 4 | NIH | 8/3/2026 | $1,453,332 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012467 | Cross-platform structural variant discovery with deep learning | 000 | 5 | NIH | 7/10/2026 | $575,926 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD111876 | Investigating epigenetic mechanisms in Down syndrome using human cellular models | 001 | 2 | NIH | 5/26/2026 | $707,150 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK140545 | Massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes | 003 | 2 | NIH | 8/12/2026 | $0 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK140545 | Massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes | 002 | 2 | NIH | 8/6/2026 | $32,400 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK140545 | Massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes | 001 | 2 | NIH | 8/5/2026 | $64,682 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK140545 | Massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes | 000 | 2 | NIH | 7/27/2026 | $668,223 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL164811 | High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes | 000 | 4 | NIH | 5/4/2026 | $656,770 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 000 | 5 | NIH | 6/23/2026 | $1,087,619 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24NS132940 | An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP) | 001 | 4 | NIH | 9/2/2026 | $581,356 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24NS132940 | An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP) | 001 | 4 | NIH | 9/2/2026 | $150,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24MH130968 | Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data | 001 | 5 | NIH | 8/3/2026 | $1,549,951 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH128366 | Unraveling the Genetic Programs Engaged in ASD Neurons Through Coupled Transcriptomic and Phenotypic Readouts | 000 | 5 | NIH | 8/5/2026 | $717,922 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 001 | 4 | NIH | 4/17/2026 | $610,231 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $400,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $250,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 5 | NIH | 4/23/2026 | $654,520 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA233626 | The function of the PRMT5 methylosome in MTAP deleted cancers | 001 | 7 | NIH | 6/19/2026 | $453,369 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01EB027793 | ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potential | 002 | 8 | NIH | 8/24/2026 | $1,056,155 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 002 | 9 | NIH | 7/14/2026 | $1,000,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 001 | 9 | NIH | 6/30/2026 | $3,430,001 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 000 | 12 | NIH | 4/9/2026 | $565,177 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 9 | NIH | 3/23/2026 | $63,674 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 9 | NIH | 1/29/2026 | $573,066 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 001 | 2 | NIH | 6/16/2026 | $0 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U54AG089325 | Virome Investigation in Diverse Human Populations | 000 | 2 | NIH | 5/1/2026 | $4,060,000 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 2 | NIH | 12/18/2025 | $722,218 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 001 | 2 | NIH | 4/17/2026 | $14,378 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA290163 | Genetic dependencies in KIAA1549-BRAF rearranged pediatric low-grade gliomas | 000 | 2 | NIH | 1/28/2026 | $129,410 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 001 | 2 | NIH | 4/27/2026 | $24,567 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 2 | NIH | 2/9/2026 | $777,944 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 001 | 4 | NIH | 5/13/2026 | $6,923,415 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI172147 | Identification and Characterization of Microbial Metabolites in Immunity | 000 | 5 | NIH | 4/24/2026 | $782,391 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 001 | 5 | NIH | 2/26/2026 | $52,929 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 5 | NIH | 12/12/2025 | $476,359 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DK137242 | Development of platforms for beta cell-specific delivery and ligand discovery | 001 | 4 | NIH | 8/10/2026 | $1,036,061 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1MH130966 | An Atlas of Human Brain Cell Variation | 000 | 5 | NIH | 7/15/2026 | $13,277,351 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24AR085003 | The Musculoskeletal Knowledge Portal | 000 | 2 | NIH | 5/26/2026 | $459,356 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R33CA291199 | A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis | 000 | 3 | NIH | 8/21/2026 | $415,682 |
| | 2026 | 2026 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS136398 | BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding | 000 | 3 | NIH | 7/24/2026 | $803,786 |
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