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 | Issue Date FY: 2025 ( Subtotal = $5,939,742 ) |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DK105554 | The next iteration of the AMP-T2D Knowledge Portal | 000 | 10 | NIH | 12/17/2024 | $3,197,364 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG013336 | Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome | 000 | 1 | NIH | 1/8/2025 | $650,625 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL177209 | From genetic basis to mechanisms for Heart Failure | 000 | 1 | NIH | 1/3/2025 | $817,208 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K25AI168451 | Physical Biology and Deep Learning for Antibiotic Resistance and Discovery | 000 | 4 | NIH | 12/5/2024 | $125,706 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 4 | NIH | 1/14/2025 | $340,185 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 4 | NIH | 11/27/2024 | $479,978 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 5 | NIH | 11/27/2024 | $211,504 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 001 | 8 | NIH | 1/13/2025 | $573,066 |
| | 2025 | 2025 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01NS132994 | Regulatory Consulting to Support Advancement of a Divalent siRNA for Prion Disease | 000 | 2 | NIH | 12/3/2024 | $98,280 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA271075 | Center for comprehensive proteogenomic data analysis | 000 | 3 | NIH | 1/6/2025 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG006834 | Broad-Geisinger Clinical Genome Resource | 000 | 11 | NIH | 12/6/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DA058235 | Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT) | 000 | 2 | NIH | 12/18/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 10 | NIH | 11/20/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 000 | 4 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 000 | 3 | NIH | 11/18/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 7 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG010262 | Expanding the AnVIL Data Ecosystem | 000 | 7 | NIH | 10/9/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 000 | 4 | NIH | 10/9/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 003 | 11 | NIH | 11/21/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 001 | 11 | NIH | 10/21/2024 | $2,116,779 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19NS132315 | Therapeutic Editing to Lower PrP in Prion Disease | 000 | 2 | NIH | 11/20/2024 | $0 |
| | 2025 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01GM137606 | Chemical approaches for precision genome editing | 000 | 4 | NIH | 12/19/2024 | $0 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 2 | NIH | 12/19/2024 | -$27,841 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms Promoting Copper Dependent Cell Death in Cancer | 000 | 1 | NIH | 11/25/2024 | -$444,739 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH131719 | Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep Spindle | 000 | 2 | NIH | 11/20/2024 | $0 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | S10MH133644 | SyncroPatch 384 Automated Patch Clamp Instrument | 000 | 1 | NIH | 10/28/2024 | -$39 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 000 | 10 | NIH | 10/21/2024 | -$2,116,779 |
| | 2025 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD002750 | The Broad-LMM-Color Genome Center for All of Us | 000 | 1 | NIH | 12/12/2024 | -$27,080 |
| | 2025 | 2022 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01CA250565 | Advanced tools for HCMI model genetic perturbation and metastasis characterization | 000 | 3 | NIH | 12/4/2024 | -$31,248 |
| | 2025 | 2022 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD101534 | Delineating a role for histone modifications in Down syndrome using human cellular models | 001 | 1 | NIH | 10/9/2024 | $0 |
| | 2025 | 2021 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R24DK110499 | A comprehensive platform for novel therapy development from the microbiome | 000 | 5 | NIH | 11/13/2024 | $0 |
| | 2025 | 2021 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI110818 | Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens | 002 | 8 | NIH | 10/24/2024 | -$23,227 |
| | 2025 | 2020 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HD101534 | Delineating a role for histone modifications in Down syndrome using human cellular models | 000 | 1 | NIH | 10/9/2024 | $0 |
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| Issue Date FY: 2024 ( Subtotal = $154,001,632 ) (Continued on the next page) |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms Promoting Copper Dependent Cell Death in Cancer | 002 | 1 | NIH | 6/21/2024 | -$31,002 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 001 | 2 | NIH | 5/3/2024 | $51,900 |
| | 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 2 | NIH | 3/15/2024 | $355,500 |
| | 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms Promoting Copper Dependent Cell Death in Cancer | 000 | 1 | NIH | 3/20/2024 | $31,002 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01DK137242 | Development of platforms for beta cell-specific delivery and ligand discovery | 000 | 2 | NIH | 7/1/2024 | $962,401 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UG3NS132135 | A Platform for Scalable Spatial Somatic Variant Profiling | 000 | 2 | NIH | 5/8/2024 | $382,724 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HG012467 | Cross-platform structural variant discovery with deep learning | 000 | 3 | NIH | 7/26/2024 | $575,926 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24CA270823 | Center of Excellence for High Throughput Proteogenomic Characterization | 001 | 3 | NIH | 6/17/2024 | $1,019,814 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 001 | 3 | NIH | 8/15/2024 | $25,080 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 8/12/2024 | $1 |
| | 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | DP5OD033430 | Transposable Element Interaction and Its Impact on Human Development and Health | 000 | 3 | NIH | 8/12/2024 | $367,039 |
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