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Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu

Award Number: U54CA283114
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu - ABSTRACT – OVERALL The primary focus of the MIT/DFCI Center for Systems Biology of Glioblastoma is to understand the intersections between neurons, immune cells, and tumor cells in this deadly tumor. The lack of response to immunotherapy strategies despite prominent infiltrates of immune cells in many GBM highlights the immuno- suppressive nature of the GBM microenvironment and the importance of more clearly understanding the dynamic interactions at the tumor/immune interface. Similarly, interactions between tumor cells and neural cells in the tumor microenvironment have emerged as driving forces in tumor progression and invasion, with electrical signals from neurons providing growth and migration stimuli to tumor cells, while tumor cells lead to aberrant electrical signaling in local neurons. The central hypothesis of this proposal is that developing a systems-level understanding of the dynamic interactions between tumor cells, neurons and immune cells will provide unprecedented insights into glioma tumor biology and foster development of novel therapeutic strategies to abrogate tumor invasion, enhance the efficacy of cytotoxic therapies, and increase clearance of tumor burden by the innate and adaptive immune system. The planned analyses will enable building an integrated computational model of tumor-neural-immune interactions for GBM tumors. The model will be based on a foundation of in vitro, in vivo, and ex vivo model systems, and then validated in dozens of human patients. Image-registered biopsies from different tumor regions within each patient will be analyzed to test predictions of this model against the ‘ground truth’ of human tumors. The ultimate goal of the MIT/DFCI Center for Systems Biology of Glioblastoma is to improve patient care by using systems biology and computational modeling to identify therapeutic strategies to specifically disrupt critical tumor cell – microenvironment interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,002,011 )
2025	2025	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Centers Support Grants	000	3	9/22/2025	NON-COMPETING CONTINUATION	$2,002,011
														Subtotal = $2,002,011

Issue Date FY: 2024 ( Subtotal = $2,060,413 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Centers Support Grants	002	2	9/5/2024	SUPPLEMENT FOR EXPANSION	$158,504
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Centers Support Grants	001	2	9/3/2024	NON-COMPETING CONTINUATION	$1,901,909
2024	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Centers Support Grants	000	1	10/27/2023	NEW	$0
														Subtotal = $2,060,413

Issue Date FY: 2023 ( Subtotal = $2,006,283 )
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Centers Support Grants	000	1	9/15/2023	NEW	$2,006,283
														Subtotal = $2,006,283

Grand Total All Awards = $6,068,707

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Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu

Award Number: U54CA283114

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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