Wednesday, October 15, 2025 10/15/2025

Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)

Award Number: U54CA277846
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP) - There are currently over 1.2 million people in Zambia and 1.7 million in Tanzania who are living with HIV/AIDS. Concomitant to the HIV epidemic, there is a high incidence of HIV/AIDS-associated malignancies (HIVAM) in these two countries. Even in this era of antiretroviral therapy (ART) Kaposi sarcoma (KS) has remained one of the most common HIVAM. This underscores a critical need for research in the context of ART-mediated changes in the HIV epidemic so that we are better equipped to diagnose, manage, and prevent KS in sub- Saharan Africa (SSA). To address this need, the overall vision of the “Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)” is to build a collaborative network between the Cancer Diseases Hospital (CDH) and University Teaching Hospitals (UTH) in Zambia, the Ocean Road Cancer Institute (ORCI) in Tanzania, and the Stanley S Scott Cancer Center at the Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO) to conduct cutting edge research that will lead to a better understanding of KS, and in parallel, continue to increase HIVAM and non-HIVAM research capacity in Zambia and Tanzania to meet the needs of the cancer patients. KEAAP’s theme centers on the research gaps of the KS disease spectrum, from detection, to care and outcomes, to deciphering KS pathogenesis and immune response towards achieving KEAAP’s overall goal to prevent and curing the disease. KEAAP’s immediate objective is to further strengthen the cancer research infrastructure in CDH/UTH and ORCI through support for interdisciplinary and bilateral KS research projects to address some of the research gaps in SSA: 1) KS diagnosis and disease staging, and linking to care; 2) changes in the immune response and metabolomes in KS patients upon treatment; and 3) identification and characterization of KSHV tissue reservoirs, and the effects of ART and HIV on these reservoirs. This proposed consortium will provide a variety of training activities in the U.S., Zambia, and Tanzania to engage the next generation of low and middle income countries and U.S. cancer researchers, increase local expertise, and increase the transfer of technology. KEAAP’s goal will be accomplished through the completion of three specific aims: 1) Develop the cancer research infrastructure at UTH/CDH and ORCI through the establishment and strengthening of three core facilities; 2) Provide an opportunity for former Fogarty trained fellows to lead three hypothesis-driven KS research projects; 3) Develop a pipeline of next- generation U.S. and LMICs cancer researchers through a) in-country workshops, b) pilot project funding, and c) short-term U.S. and in-country training. KEAAP is high impact because it builds on successful ongoing Fogarty and NCI training programs; it will implement a cross-disciplinary and tri-lateral research and training program that are driven by our Tanzanian and Zambian collaborators with broad local support to ensure their sustainability. The lessons learned will also benefit Louisiana HIV-1 and cancer research since the state has the fifth largest population of people living with HIV, mostly among its health under-supported population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $924,561 )
2025	2025	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	003	3	9/19/2025	SUPPLEMENT FOR EXPANSION	$282,153
2025	2025	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	002	3	9/19/2025	SUPPLEMENT FOR EXPANSION	$251,791
2025	2025	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	001	3	9/17/2025	NON-COMPETING CONTINUATION	$390,617
2025	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	000	2	4/23/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $924,561

Issue Date FY: 2024 ( Subtotal = $1,050,894 )
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	003	2	9/23/2024	SUPPLEMENT FOR EXPANSION	-$19,964
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	001	2	9/4/2024	NON-COMPETING CONTINUATION	$925,902
2024	2024	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	002	2	9/17/2024	SUPPLEMENT FOR EXPANSION	$144,956
2024	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER NEW ORLEANS	433 BOLIVAR ST RM 619	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	000	1	1/3/2024	NEW	$0
														Subtotal = $1,050,894

Issue Date FY: 2023 ( Subtotal = $920,550 )
2023	2023	LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER-NEW ORLEANS	433 BOLIVAR ST STE 815	NEW ORLEANS	LA	70112	ORLEANS	USA	Cancer Centers Support Grants	000	1	8/17/2023	NEW	$920,550
														Subtotal = $920,550

Grand Total All Awards = $2,896,005

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Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)

Award Number: U54CA277846

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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