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3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership

Award Number: U54CA118948
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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OVERALL: PROJECT SUMMARY: (Overall is identical to all three partnering institutions) This type-2 application is to strengthen and build upon the established U54 Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the UAB O’Neal Comprehensive Cancer Center (UAB OCCC). The Partnership, located in the heart of the Southeast, a region with a large, historically underserved, African American (AA) population, has the overall goal of attaining excellence in research focused on elimination of cancer health disparities and on reducing the cancer burden among underserved populations in the region. The partnering institutions possess distinctive strengths that complement each other in achieving the proposed goal through integrated research, education, and outreach. The primary objectives are to enhance productive cancer research programs, to develop a pipeline of racial/ethnic minority investigators in cancer research at MSM and TU, and to increase the level of involvement of investigators conducting research on cancer disparities at the UAB OCCC. The Partnership has four Cores (Administrative, Outreach, Research Education, and Planning & Evaluation); two Full Research Projects; one Pilot Research Project; and two Shared Resources (Bioethics and Biostatistics/Bioinformatics). With these assets and activities, the Partnership will: 1) through the two full projects, a) determine if amplification and overexpression of TRIP13 contribute to prostate cancer aggressiveness and progression and b) develop combination therapy strategies that modulate the immune microenvironment for colorectal cancers and identify alternative targets adaptable to personalized medicine. The overall objectives of the Pilot Project are to characterize factors associated with uptake of lung cancer screening (LCS) in two different health care systems and to explore barriers and facilitators to LCS at the system, provider, and patient levels that will inform the development of a multi-level intervention. 2) through the Outreach Core, implement and evaluate an evidence-based, theory-informed, multi-level, clinical trial and cancer genomics education program that addresses the determinants for AA and Latinx participation in clinical trials and cancer genomics studies; 3) through the Research Education Core, employ an integrated research education program that involves capacity building and linkages to high school, undergraduate and graduate/medical students, postdoctoral fellows, medical residents, and early-stage investigators, allowing them to pursue careers in cancer research; and 4) provide funding for additional Pilot Research projects. The Planning & Evaluation Core will continually assess/evaluate outcomes of the cores, research projects, and shared resources. The Bioethics Shared Resource will promote and ensure adherence to bioethical principles and address ethical considerations in relationships between the institutions and between the institutions and communities. The Biostatistics and Bioinformatics Shared Resource will deliver statistical and bioinformatics support for all activities. Together, these actions will contribute to elimination of cancer health disparities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,351,922 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	002	19	9/11/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	19	8/8/2024	NON-COMPETING CONTINUATION	$1,351,922
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	18	4/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,351,922

Issue Date FY: 2023 ( Subtotal = $1,394,613 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	18	8/16/2023	NON-COMPETING CONTINUATION	$1,394,613
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	17	4/26/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,394,613

Issue Date FY: 2022 ( Subtotal = $1,398,325 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	007	17	7/27/2022	NON-COMPETING CONTINUATION	$1,212,700
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	008	17	8/10/2022	SUPPLEMENT FOR EXPANSION	$185,625
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	003	16	3/8/2022	COMPETING CONTINUATION	-$90,986
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	005	16	3/14/2022	COMPETING CONTINUATION	$92,638
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	16	12/22/2021	COMPETING CONTINUATION	$90,986
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	006	16	4/11/2022	COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	002	15	3/8/2022	NON-COMPETING CONTINUATION	$90,986
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	15	12/22/2021	NON-COMPETING CONTINUATION	-$90,986
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	004	15	3/14/2022	NON-COMPETING CONTINUATION	-$92,638
														Subtotal = $1,398,325

Issue Date FY: 2021 ( Subtotal = $1,237,451 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	16	9/22/2021	COMPETING CONTINUATION	$1,237,451
														Subtotal = $1,237,451

Issue Date FY: 2020 ( Subtotal = $1,380,163 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	15	8/25/2020	NON-COMPETING CONTINUATION	$1,380,163
														Subtotal = $1,380,163

Issue Date FY: 2019 ( Subtotal = $1,299,477 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	14	9/5/2019	SUPPLEMENT FOR EXPANSION	$206,996
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	14	7/24/2019	NON-COMPETING CONTINUATION	$1,092,481
														Subtotal = $1,299,477

Issue Date FY: 2018 ( Subtotal = $1,170,535 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	13	8/24/2018	NON-COMPETING CONTINUATION	$1,170,535
														Subtotal = $1,170,535

Issue Date FY: 2017 ( Subtotal = $1,170,535 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	004	12	8/31/2017	NON-COMPETING CONTINUATION	$1,170,535
2017	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	003	11	4/27/2017	COMPETING CONTINUATION	-$10,694
2017	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	11	1/31/2017	COMPETING CONTINUATION	$68,230
2017	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	10	1/31/2017	SUPPLEMENT FOR EXPANSION	-$68,230
2017	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	002	10	4/27/2017	SUPPLEMENT FOR EXPANSION	$10,694
														Subtotal = $1,170,535

Issue Date FY: 2016 ( Subtotal = $1,499,937 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	004	11	9/23/2016	SUPPLEMENT FOR EXPANSION	$162,279
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	003	11	9/23/2016	COMPETING CONTINUATION	$1,337,658
2016	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Cancer Centers Support Grants	000	10	9/20/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Cancer Centers Support Grants	001	10	9/20/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Cancer Centers Support Grants	002	10	9/20/2016	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,499,937

Issue Date FY: 2015 ( Subtotal = $1,455,259 )
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	002	10	8/28/2015	SUPPLEMENT FOR EXPANSION	$199,999
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	10	8/24/2015	NON-COMPETING CONTINUATION	$1,100,542
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	10	8/26/2015	SUPPLEMENT FOR EXPANSION	$154,718
														Subtotal = $1,455,259

Issue Date FY: 2014 ( Subtotal = $1,363,687 )
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	002	9	9/19/2014	SUPPLEMENT FOR EXPANSION	$100,000
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	001	9	9/18/2014	SUPPLEMENT FOR EXPANSION	$155,159
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	9	8/28/2014	NON-COMPETING CONTINUATION	$1,058,529
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	003	9	9/22/2014	SUPPLEMENT FOR EXPANSION	$49,999
														Subtotal = $1,363,687

Issue Date FY: 2013 ( Subtotal = $1,018,948 )
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cancer Centers Support Grants	000	8	9/12/2013	NON-COMPETING CONTINUATION	$1,018,948
														Subtotal = $1,018,948

Issue Date FY: 2012 ( Subtotal = $1,030,563 ) (Continued on the next page)
Grand Total All Awards = $23,047,708

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3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership

Award Number: U54CA118948

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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