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Consortium of Eosinophilic Gastrointestinal Disease Researchers-HEROs Supplement

Award Number: U54AI117804
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract This Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR) study will enroll approximately 150 families to assess how SARS-COV-2 differentially affects children with Eosinophilic Gastrointestinal Disorders (EGIDs) compared to children without these disorders. The proposed work is part of the larger Human Epidemiology and Response to SARS-CoV-2 (HEROS) study that allows a comparison between children with atopic conditions and children without those conditions. Although asthma has not been identified as a clear risk factor for severe COVID-19 disease, there is evidence that children with asthma and other atopic conditions have increased susceptibility to viral respiratory infections (Esquivel et al, AJRCCM, PMC5649984) and that viral respiratory infections may result in worsening of underlying airway disease (Jartti et al, J Allergy Clin Immunol, PMID 28987219). No data currently exist as to whether this is true for SARS-CoV-2 infection or whether allergic airway disease could be protective. Enrolled families will participate for 6 months completing surveys and biological sample collections. These children and their families are already enrolled in the CEGIR NIH funded studies and therefore will overcome many challenges for clinical study implementation. This proposed work remains in scope to the parent award and is responsive to the NOT-AI-20-031.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,840,643 )
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	10	8/25/2023	NON-COMPETING CONTINUATION	$400,000
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	10	8/11/2023	NON-COMPETING CONTINUATION	$1,440,643
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	002	10	9/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,840,643

Issue Date FY: 2022 ( Subtotal = $1,449,842 )
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	002	9	8/15/2022	NON-COMPETING CONTINUATION	$1,449,842
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	003	9	9/12/2022	NON-COMPETING CONTINUATION	$0
2022	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	6	5/20/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	7	4/13/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,449,842

Issue Date FY: 2021 ( Subtotal = $1,459,657 )
2021	2021	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	8	8/31/2021	NON-COMPETING CONTINUATION	$1,459,657
2021	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	7	5/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,459,657

Issue Date FY: 2020 ( Subtotal = $1,771,444 )
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	002	6	6/16/2020	SUPPLEMENT FOR EXPANSION	$114,280
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	003	6	7/24/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	005	7	8/24/2020	SUPPLEMENT FOR EXPANSION	$138,242
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	004	7	8/19/2020	NON-COMPETING CONTINUATION	$1,518,922
2020	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	6	4/4/2020	COMPETING CONTINUATION	$35,281
2020	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	5	4/4/2020	NON-COMPETING CONTINUATION	-$35,281
														Subtotal = $1,771,444

Issue Date FY: 2019 ( Subtotal = $1,770,730 )
2019	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	6	9/17/2019	COMPETING CONTINUATION	$1,770,730
2019	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	5	9/16/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,770,730

Issue Date FY: 2018 ( Subtotal = $1,249,999 )
2018	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	5	8/3/2018	NON-COMPETING CONTINUATION	$1,249,999
2018	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	002	5	9/12/2018	NON-COMPETING CONTINUATION	$0
2018	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	5	8/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,249,999

Issue Date FY: 2017 ( Subtotal = $1,449,958 )
2017	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	4	8/23/2017	NON-COMPETING CONTINUATION	$199,959
2017	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	4	8/4/2017	NON-COMPETING CONTINUATION	$1,249,999
														Subtotal = $1,449,958

Issue Date FY: 2016 ( Subtotal = $1,596,844 )
2016	2016	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	3	8/3/2016	NON-COMPETING CONTINUATION	$1,249,999
2016	2016	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	3	8/16/2016	NON-COMPETING CONTINUATION	$346,845
														Subtotal = $1,596,844

Issue Date FY: 2015 ( Subtotal = $1,245,751 )
2015	2015	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	2	7/23/2015	NON-COMPETING CONTINUATION	$1,245,751
														Subtotal = $1,245,751

Issue Date FY: 2014 ( Subtotal = $1,250,000 )
2014	2014	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	001	1	8/13/2014	NEW	$0
2014	2014	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Allergy and Infectious Diseases Research	000	1	8/12/2014	NEW	$1,250,000
														Subtotal = $1,250,000

Grand Total All Awards = $15,084,868

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Consortium of Eosinophilic Gastrointestinal Disease Researchers-HEROs Supplement

Award Number: U54AI117804

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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