Sunday, April 28, 2024 4/28/2024

Center for Health Promotion and Disease Prevention

Award Number: U48DP005017
ORGANIZATION: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION & HEALTH PROMOTION
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY/ABSTRACT Breast cancer is the most common non-skin cancer among females in the United States (US) and the second leading cause of cancer death in women. Although less than 10% of all breast cancers are diagnosed among women younger than age 45, incidence during the past 30 years has increased faster among younger women than among women older than 40. Although research has recently begun characterizing the economic burden of breast cancer among younger women, the vast majority of the literature on the economic impact of breast cancer has focused on early stage cancers among older women (aged 65 and older). More research is needed to understand the economic impact of metastatic breast cancer among women at all stages of life. Medical treatment for metastatic breast cancer is not intended to “cure” the cancer but rather to extend the life of the patient and/or improve the patient's quality of life. Several new treatments for metastatic breast cancer have been introduced in recent years. However, more studies are needed that estimate the value of oncology clinical pathways for metastatic breast cancer, as these treatments can be costly with limited survival benefit. The overall goal of this study is to assess the economic burden of metastatic breast cancer across the lifetime and to evaluate the cost effectiveness of alternative clinical pathways for metastatic breast cancer. Our study will estimate the costs of metastatic breast cancer to women in three age groups: younger (aged 18 to 44), midlife (aged 45 to 64) and older (aged 65 and older). We will estimate three types of costs: medical costs, the cost of not being able to work, and the cost of lost earnings from dying prematurely (Aim 1). We will then scale the estimates of the per-person costs to the population level and use US Census projections to project the overall economic burden of metastatic breast cancer out through the year 2030 (Aim 2). Finally, we will estimate the cost-effectiveness of different oncology clinical pathways in the first to third line treatment of patients with endocrine-sensitive, endocrine-refractory or triple negative, and HER2- overexpressing metastatic breast cancer among younger, midlife and older women. While several treatment options for metastatic breast cancer may increase a patient's life, the amount of extra time provided and the cost of the treatment to health insurance and the patient can vary dramatically. When comparing oncology clinical pathways, cost effectiveness analysis provides information about the extra cost per unit of additional healthy life-years gained from choosing one treatment over another. The economic cost data produced by this study will help decision makers allocate scarce public health resources more effectively for the prevention and treatment of metastatic breast cancer. The cost projections can highlight cost drivers for women with metastatic breast cancer and motivate appropriate prevention and early detection public health activities. This study will also identify cost-effective oncology clinical pathways to improve the value of care and health-related quality of life of women of all ages with metastatic breast cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	08	5	5/27/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	06	5	2/7/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	07	5	2/10/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	06	5	2/7/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	08	5	5/27/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2016	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	08	5	5/27/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2016	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	06	5	2/7/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2015	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	08	5	5/27/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2015	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	06	5	2/7/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2014	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	08	5	5/27/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2014	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	06	5	2/7/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = -$7,131 )
2021	2015	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	05	5	6/16/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$7,131
														Subtotal = -$7,131

Issue Date FY: 2020 ( Subtotal = -$97,377 )
2020	2018	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	04	5	9/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$97,377
2020	2017	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	04	5	9/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2016	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	04	5	9/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2015	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	04	5	9/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2014	University of North Carolina at Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	04	5	9/11/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$97,377

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	03	5	5/30/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	01	5	2/13/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	02	5	4/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2016	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	02	5	4/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2016	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	03	5	5/30/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2015	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	02	5	4/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2015	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	03	5	5/30/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $2,121,727 )
2018	2018	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	00	5	8/31/2018	NON-COMPETING CONTINUATION	$2,121,727
2018	2017	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	03	4	7/3/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2018	2017	University Of North Carolina At Chapel Hill	104 Airport Dr Ste 2200	Chapel Hill	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	02	4	6/20/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $2,121,727

Issue Date FY: 2017 ( Subtotal = $2,041,738 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	005	4	9/12/2017	SUPPLEMENT FOR EXPANSION	$253,545
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	003	4	8/15/2017	NON-COMPETING CONTINUATION	$1,788,193
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	000	3	6/19/2017	NON-COMPETING CONTINUATION	$0
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	001	3	6/30/2017	NON-COMPETING CONTINUATION	$0
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	002	3	7/7/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	004	3	9/7/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,041,738

Issue Date FY: 2016 ( Subtotal = $2,058,193 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	007	3	8/4/2016	SUPPLEMENT FOR EXPANSION	$229,193
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	008	3	8/30/2016	NON-COMPETING CONTINUATION	$0
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	006	3	7/18/2016	NON-COMPETING CONTINUATION	$1,829,000
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	001	2	3/23/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	005	2	7/1/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	000	2	1/14/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Centers for Research and Demonstration for Health Promotion and Disease Prevention	002	2	5/24/2016	NON-COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Health Promotion and Disease Prevention Research Centers: PPHF - Affordable Care Act Projects	004	2	6/24/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Health Promotion and Disease Prevention Research Centers: PPHF - Affordable Care Act Projects	009	2	8/31/2016	SUPPLEMENT FOR EXPANSION	$0
2016	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Health Promotion and Disease Prevention Research Centers: PPHF - Affordable Care Act Projects	003	1	6/17/2016	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,058,193

Grand Total All Awards = $10,805,651

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Center for Health Promotion and Disease Prevention

Award Number: U48DP005017

ORGANIZATION: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION & HEALTH PROMOTION

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

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