Tuesday, April 1, 2025 4/1/2025

A Carolina Center to Characterize and Maintain Mutant Mice

Award Number: U42OD010924
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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A Carolina Center to Characterize and Maintain Mutant Mice - PROJECT SUMMARY For decades, the mouse has been the premier animal model for studies of human disease, providing the opportunity to explore experimental questions that are intractable for direct study in humans. As a result, key mechanistic insights have been obtained for various clinical conditions to inform therapeutic development. Spurred by advances in technology and international efforts to systematically knock out all of the protein coding genes in the genome, the number of genetically engineered mice has expanded rapidly in the past 20+ years. The responsibility for maintenance and distribution of mutant mice was initially placed on individual investigators, which was a tremendous burden in terms of cost, labor and space. In 1999, the NIH recognized the need for a resource to protect the investment in mutant mouse strains and ensure open access to all biomedical researchers. It established the Mutant Mouse Resource and Research Centers (MMRRC) to meet this need. Since 1999, the central goal of the MMRRC-UNC has been to work collectively with MMRRC consortium partners to develop and maintain high standards for importation, rederivation, cryopreservation, and distribution of mutant mouse strains to biomedical investigators and incorporate research goals that synergize with and extend the value of the resource. The MMRRC-UNC will continue contributing to these Consortium goals by implementing the following Specific Aims in the next project period: 1) Streamline and improve operating procedures to continue the efficient importation, distribution, and cryopreservation of mouse strains created by investigators throughout the United States and beyond. 2) Support the distribution and enhance the scientific value and long-term stability of the Collaborative Cross (CC) resource. 3) Implement Genetic QC (GQC) procedures to enhance the rigor and reproducibility of mouse models distributed by the MMRRC and advocate for their adoption across the biomedical research community. 4) Investigate the interaction of genetics and environment on experimental efficiency, variability, and reproducibility.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,166,141 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	26	3/14/2025	COMPETING CONTINUATION	$1,166,141
														Subtotal = $1,166,141

Issue Date FY: 2024 ( Subtotal = $1,457,678 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	25	5/23/2024	NON-COMPETING CONTINUATION	$291,535
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	25	1/22/2024	NON-COMPETING CONTINUATION	$1,166,143
														Subtotal = $1,457,678

Issue Date FY: 2023 ( Subtotal = $1,460,926 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	24	2/23/2023	NON-COMPETING CONTINUATION	$146,091
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	24	2/9/2023	NON-COMPETING CONTINUATION	$1,314,835
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	23	12/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,460,926

Issue Date FY: 2022 ( Subtotal = $1,464,039 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	23	6/3/2022	NON-COMPETING CONTINUATION	$146,407
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	23	2/15/2022	NON-COMPETING CONTINUATION	$1,317,632
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	22	12/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,464,039

Issue Date FY: 2021 ( Subtotal = $1,966,919 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	22	8/2/2021	SUPPLEMENT FOR EXPANSION	$499,997
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	22	3/5/2021	NON-COMPETING CONTINUATION	$1,466,922
														Subtotal = $1,966,919

Issue Date FY: 2020 ( Subtotal = $1,760,611 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	21	1/14/2020	COMPETING CONTINUATION	$1,259,778
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	004	21	6/5/2020	COMPETING CONTINUATION	$283
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	21	4/14/2020	COMPETING CONTINUATION	$209,971
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	005	21	8/28/2020	SUPPLEMENT FOR EXPANSION	$290,862
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	20	3/10/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	003	20	6/5/2020	NON-COMPETING CONTINUATION	-$283
														Subtotal = $1,760,611

Issue Date FY: 2019 ( Subtotal = $1,399,761 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	20	9/25/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	20	2/5/2019	NON-COMPETING CONTINUATION	$1,399,761
														Subtotal = $1,399,761

Issue Date FY: 2018 ( Subtotal = $1,835,334 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	19	1/11/2018	NON-COMPETING CONTINUATION	$1,259,785
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	19	8/27/2018	SUPPLEMENT FOR EXPANSION	$435,573
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	19	6/5/2018	NON-COMPETING CONTINUATION	$139,976
														Subtotal = $1,835,334

Issue Date FY: 2017 ( Subtotal = $1,329,773 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	18	8/10/2017	NON-COMPETING CONTINUATION	$69,940
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	18	1/26/2017	NON-COMPETING CONTINUATION	$1,259,833
														Subtotal = $1,329,773

Issue Date FY: 2016 ( Subtotal = $1,399,761 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	17	2/8/2016	NON-COMPETING CONTINUATION	$139,976
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	17	1/11/2016	NON-COMPETING CONTINUATION	$1,259,785
														Subtotal = $1,399,761

Issue Date FY: 2015 ( Subtotal = $1,399,761 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	16	4/6/2015	COMPETING CONTINUATION	$1,399,761
														Subtotal = $1,399,761

Issue Date FY: 2014 ( Subtotal = $1,677,579 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	15	3/25/2014	NON-COMPETING CONTINUATION	$1,429,301
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	15	9/5/2014	SUPPLEMENT FOR EXPANSION	$14,998
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	15	8/5/2014	SUPPLEMENT FOR EXPANSION	$233,280
														Subtotal = $1,677,579

Issue Date FY: 2013 ( Subtotal = $1,372,998 )
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	14	2/15/2013	NON-COMPETING CONTINUATION	$1,299,366
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	14	5/20/2013	NON-COMPETING CONTINUATION	$73,632
														Subtotal = $1,372,998

Issue Date FY: 2012 ( Subtotal = $1,443,739 )
2012	2012	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	13	2/27/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,443,739
														Subtotal = $1,443,739

Grand Total All Awards = $21,135,020

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A Carolina Center to Characterize and Maintain Mutant Mice

Award Number: U42OD010924

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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