Tuesday, December 30, 2025 12/30/2025

Cleveland Open Source Modular Implant Innovators Community (COSMIIC)

Award Number: U41NS129436
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Cleveland Open Source Modular Implant Innovators Community (COSMIIC) - The overall goal of the Cleveland Open Source Modular Implant Innovators Community (COSMIIC) is to establish an open source, modular network of active implantable devices for use in early feasibility human research and to provide ongoing support for this technology through a vibrant, sustainable community of active users. Our team is poised to successfully achieve all of the goals of the HORNET program because our proposed concept is based on our established platform ecosystem, the Networked Neuroprosthesis (NNP). This provides a solid technological platform with known regulatory status for our COSMIIC HORNET project. Critically, all technology described in this proposal was invented by the investigative team and therefore we are able to fully embrace the open source ideology for the end-to-end technology. The proposed COSMIIC HORNET System, which will be established on the platform NNP System, is a system of interoperable and integrated modules that can simultaneously electrically activate, block, and sense throughout the body. The system can record and process electroneurogram (ENG), electromyogram (EMG), intracortical signals, electrocardiogram (EKG), kinematic variables, photoplethysmogram (PPG), and temperature. Each module can directly communicate with all other modules through an established network communication protocol. The system can process signals to implement complex closed-loop control without requiring non-implanted hardware. Importantly, the existing NNP platform components (power module, stimulator module, biopotential recording module, network cable, electrodes) already have IDE approval from the FDA and have been successfully implanted and implemented in human research participants. Thus, the COSMIIC HORNET System has the necessary features to provide the modular platform ecosystem for use by the bioelectronic community for the foreseeable future. Aim #1. Dissemination. We will establish the COSMIIC community with full open-source access to an established modular implantable device for use in the peripheral and central nervous system. Access will be given for all circuit designs and layouts; mechanical drawings for all enclosures and connectors and cabling; the annotated code for all operating software, firmware, and bootloader; written instructions and videos of fabrication techniques; and all regulatory documents and test data, including our approved IDE document. Aim #2. Sustainability. We will develop a sustainable open source model through the development of technology that attracts a broad investigative team to establish a critical mass of COSMIIC users. We will provide ongoing support of the technology and partner with commercial partners to create a sustainable business plan so that the COSMIIC community remains independently vibrant and active after three years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	000	3	12/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	000	2	11/22/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	001	3	1/23/2025	NON-COMPETING CONTINUATION	$0
2025	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	002	3	9/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $6,189,774 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	000	2	8/5/2024	SUPPLEMENT FOR EXPANSION	$86,632
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	004	2	8/9/2024	SUPPLEMENT FOR EXPANSION	$54,905
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	001	2	8/6/2024	SUPPLEMENT FOR EXPANSION	$40,851
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	008	2	8/16/2024	SUPPLEMENT FOR EXPANSION	$69,063
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	002	2	8/7/2024	SUPPLEMENT FOR EXPANSION	$70,556
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	003	2	8/8/2024	SUPPLEMENT FOR EXPANSION	$86,273
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	007	2	8/14/2024	SUPPLEMENT FOR EXPANSION	$26,100
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	006	2	8/13/2024	SUPPLEMENT FOR EXPANSION	$121,297
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	010	3	9/11/2024	SUPPLEMENT FOR EXPANSION	$49,405
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	009	3	8/30/2024	NON-COMPETING CONTINUATION	$5,510,784
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	005	2	8/12/2024	SUPPLEMENT FOR EXPANSION	$73,908
														Subtotal = $6,189,774

Issue Date FY: 2023 ( Subtotal = $4,346,841 )
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	001	2	9/1/2023	NON-COMPETING CONTINUATION	$4,346,841
2023	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	000	1	1/27/2023	NEW	$0
														Subtotal = $4,346,841

Issue Date FY: 2022 ( Subtotal = $4,249,268 )
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Trans-NIH Research Support	000	1	9/9/2022	NEW	$4,249,268
														Subtotal = $4,249,268

Grand Total All Awards = $14,785,883

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Cleveland Open Source Modular Implant Innovators Community (COSMIIC)

Award Number: U41NS129436

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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