Wednesday, December 31, 2025 12/31/2025

The Human Pangenome Reference Consortium Coordination Center

Award Number: U41HG010972
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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The Human Pangenome Reference Consortium Coordination Center - PROJECT SUMMARY (Overall: Human Pangenome Coordination Center) The human reference genome has been the cornerstone of human genetics and genomics research for over twenty years. However, there is a broad consensus that no single reference sequence can fully represent the spectrum of genomic diversity across global populations. Advances in sequencing technologies and a greater appreciation for the importance of genetic diversity make improving the human reference sequence both timely and practical. With advances in long-read sequencing technologies and computational methods, it is now feasible to construct a human pangenome reference that captures and represents the full compendium of genetic variation from a large collection of diverse genomes. We will extend the successful infrastructure developed by the Human Pangenome Reference Consortium Coordination Center. In the next phase, we will significantly improve the human pangenome reference by representing as much human genetic variation as needed to meet disparate scientific and clinical applications, while engaging with international partners and the global research community to provide a widely accessible and user friendly pangenomic resource and tool ecosystem. During the second phase of the Human Pangenome Reference Consortium, our Coordination Center will: i) Continue to maintain and improve the pangenome reference, including supporting the generation of additional diverse, reference quality sequence assemblies; ii) Facilitate adoption of the pangenome reference by the broad research and clinical genetics and genomics communities; iii) Foster the development and deployment of user-friendly informatics tools for the pangenome; iv) Facilitate embedded ELSI research; and, v) Develop international partnerships to ensure that the human pangenome reference engages with the populations it seeks to represent.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	7	11/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $229,124 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	002	7	9/23/2025	SUPPLEMENT FOR EXPANSION	$229,124
2025	2024	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	6	3/4/2025	COMPETING CONTINUATION	$1,103,884
2025	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	5	3/4/2025	NON-COMPETING CONTINUATION	-$1,103,884
														Subtotal = $229,124

Issue Date FY: 2024 ( Subtotal = $2,900,800 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Human Genome Research	002	6	8/30/2024	COMPETING CONTINUATION	$2,900,800
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Human Genome Research	000	5	7/25/2024	NON-COMPETING CONTINUATION	$0
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Human Genome Research	001	5	8/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,900,800

Issue Date FY: 2023 ( Subtotal = $2,740,915 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	5	8/31/2023	NON-COMPETING CONTINUATION	$2,740,915
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	4	4/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,740,915

Issue Date FY: 2022 ( Subtotal = $2,750,194 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	4	8/31/2022	NON-COMPETING CONTINUATION	$0
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	4	8/23/2022	NON-COMPETING CONTINUATION	$2,750,194
														Subtotal = $2,750,194

Issue Date FY: 2021 ( Subtotal = $2,758,218 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	002	3	8/19/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	3	7/23/2021	NON-COMPETING CONTINUATION	$2,508,218
2021	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	2	6/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,758,218

Issue Date FY: 2020 ( Subtotal = $2,515,410 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	2	7/17/2020	NON-COMPETING CONTINUATION	$2,515,410
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	2	8/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,515,410

Issue Date FY: 2019 ( Subtotal = $2,565,095 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	1	9/18/2019	NEW	$2,565,095
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	1	9/23/2019	NEW	$0
														Subtotal = $2,565,095

Grand Total All Awards = $16,459,756

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The Human Pangenome Reference Consortium Coordination Center

Award Number: U41HG010972

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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