Friday, November 22, 2024 11/22/2024

The Center for High Content Functional Annotation of Natural Products

Award Number: U41AT008718
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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It has been well documented that the outcomes of success for botanical clinical trials have been poor, leading to greater effort into understanding the basic mechanisms underlying their activity. While it is often hypothesized that botanicals or other complex mixtures work through synergistic or additive processes, there are few proven examples. There is also growing belief to support the role of gut microbiome metabolism for generation of active metabolites, however, relatively few experimental results back this up. This is driven by limitations in obtaining clear biological signatures in relevant biological assays, in accurately defining the chemical constitution of complex mixtures, and in the informatics approaches to bring these disparate data types together. This proposal aims to address these important questions by the development and implementation of technology platforms. In project 1, we will employ highly innovative orthogonal cell-based high content phenotypic screening approaches in primary macrophages, epithelial cells, primary neurons, which will give us comprehensive coverage of signaling pathway and receptor that are believed to be relevant to botanicals. These platforms aim to link botanicals/bioactive molecules of interest together with information about their molecular targets. These platforms have been demonstrated to work with complex mixtures as well as pure compounds and are supported by the development of bioinformatic approaches that allow integration of orthogonal biological activity. Our second project will take advantage of developments in untargeted metabolomics, along with feature reduction, to have a robust pipeline to clearly define the constitution of complex mixtures. Our third project specifically addresses the question of synergy and additivity by the development of informatics approaches that use the comprehensive biological and chemical signatures generated in the other projects. In this project, we will develop universal tools that will allow the community to probe their own biological and chemical assay results to generate compound/activity maps. This program will deliver critical technology platforms for the in-depth study of botanicals and natural products and deliver tools that can be used by the community


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $976,696 )
2024	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	11	7/22/2024	NON-COMPETING CONTINUATION	$976,696
														Subtotal = $976,696

Issue Date FY: 2023 ( Subtotal = $976,696 )
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	10	7/19/2023	NON-COMPETING CONTINUATION	$976,696
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	001	10	9/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $976,696

Issue Date FY: 2022 ( Subtotal = $976,696 )
2022	2022	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	9	9/8/2022	NON-COMPETING CONTINUATION	$976,696
2022	2022	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	001	9	9/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $976,696

Issue Date FY: 2021 ( Subtotal = $976,696 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	004	8	7/7/2021	NON-COMPETING CONTINUATION	$976,696
2021	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	002	7	2/11/2021	COMPETING CONTINUATION	$977,278
2021	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	003	7	3/8/2021	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	001	6	2/11/2021	NON-COMPETING CONTINUATION	-$894,780
2021	2018	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	5	2/11/2021	NON-COMPETING CONTINUATION	-$82,498
														Subtotal = $976,696

Issue Date FY: 2020 ( Subtotal = $1,245,590 )
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	002	7	7/1/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	004	7	9/16/2020	SUPPLEMENT FOR EXPANSION	$241,894
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	001	7	6/23/2020	COMPETING CONTINUATION	$1,003,696
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	003	7	7/2/2020	COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	6	11/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,245,590

Issue Date FY: 2019 ( Subtotal = $894,780 )
2019	2019	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	001	6	7/3/2019	NON-COMPETING CONTINUATION	$894,780
2019	2018	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	000	5	2/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $894,780

Issue Date FY: 2018 ( Subtotal = $871,600 )
2018	2018	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	006	5	7/2/2018	NON-COMPETING CONTINUATION	$908,074
2018	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	001	3	5/23/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	004	3	6/19/2018	SUPPLEMENT FOR EXPANSION	-$301,000
2018	2017	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	005	4	6/20/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$612,583
2018	2017	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Research and Training in Complementary and Integrative Health	002	4	5/24/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$590,750
2018	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	000	3	5/22/2018	NON-COMPETING CONTINUATION	-$627,224
2018	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	003	3	6/19/2018	NON-COMPETING CONTINUATION	-$311,583
														Subtotal = $871,600

Issue Date FY: 2017 ( Subtotal = $1,257,743 )
2017	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	001	3	9/8/2017	SUPPLEMENT FOR EXPANSION	$301,000
2017	2017	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	000	3	6/27/2017	NON-COMPETING CONTINUATION	$956,743
														Subtotal = $1,257,743

Issue Date FY: 2016 ( Subtotal = $964,292 )
2016	2016	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CTR DALLAS	5323 HARRY HINES BOULEVARD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	001	2	8/26/2016	NON-COMPETING CONTINUATION	$0
2016	2016	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CTR DALLAS	5323 HARRY HINES BOULEVARD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	000	2	6/28/2016	NON-COMPETING CONTINUATION	$964,292
														Subtotal = $964,292

Issue Date FY: 2015 ( Subtotal = $993,265 )
2015	2015	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CTR DALLAS	5323 HARRY HINES BOULEVARD	DALLAS	TX	75390	DALLAS	USA	Research and Training in Complementary and Integrative Health	000	1	8/31/2015	NEW	$993,265
														Subtotal = $993,265

Grand Total All Awards = $10,134,054

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The Center for High Content Functional Annotation of Natural Products

Award Number: U41AT008718

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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