The recipient, Massachusetts General Hospital, supports this five-year Regional Emerging Special Pathogen Treatment Center Cooperative Agreement project. The goal of this project is to work with our healthcare, public health, and EMS partners to assure that patients with suspected or confirmed High Consequence Infectious Diseases (HCIDs) receive the safest and best care possible in the most appropriate clinical location at every stage of their care. We support this mission through three objectives: 1) ensuring our specialized HCID care units at MGH are always prepared, equipped, and trained to the highest standards, 2) promoting Regionwide HCID readiness supported by expert education, training, exercising, and collaborative consultations from our RESPTC, and 3) working with identified healthcare facilities and our public health and EMS partners in planning and response to ensure patients with suspected or confirmed HCID infections can move efficiently and safely to appropriate expert receiving healthcare facilities equipped to care for the patient for the duration of their illness. The expected outcomes of this project are 1) ongoing readiness to safely care for patients with HCIDs within the MGH BCU when needed, 2) increased capabilities among the entire Region’s healthcare facilities for safe identification and isolation of, and initiation of care for patients with HCIDs, and 3) an updated Regional plan for the care of patients with HCIDs supported by enhanced communications and patient transportation protocols. The products from this project are a functioning BCU at MGH, a robust Regional training program, and an updated Regional HCID plan.