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2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US

Award Number: U2RTW010108
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/28/2015
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US - Project Summary/Abstract Environmental exposures are major contributors to illness and premature death in countries around the world. Air pollution is especially concerning as it promotes chronic cardiometabolic disease and can trigger acute cardiac events. In rapidly urbanizing India, an estimated 1.67 million deaths per year are attributed to air pollution, making it a factor in nearly 18% of total deaths and 11.5% of total disability adjusted life years. While the link between air pollution and ill health is becoming clearer, we need to learn more how the components of air pollution interact with each other and with other elements of the exposome such as heat, to affect health This is especially important in LMIC cities, where industry and traffic generate pollution and climate change is causing unprecedented heat waves. We also need to identify sensitive ages where air pollution exposure can be particularly detrimental. Children pass through critical windows of development when they are highly sensitive to exposures. Older adults are more likely to experience cardiac events when air pollution and heat levels rise. In addition, exposures differ for people of different ages, gender, occupations, and socioeconomic status. To address this complex situation, India needs experts trained in environmental health to carry out research and recommend effective policies to mitigate air pollution exposure and protect those most vulnerable to its effects. In this proposed project, entitled, “2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US,” our multidisciplinary team of researchers, mentors and faculty from the Harvard T.H. Chan School of Public Health (HSPH) and the Centre for Chronic Disease Control (CCDC) will build on knowledge gained in our original GEOHealth project in which trainees and mentors developed models to estimate levels of ambient PM2.5 in Indian cities and quantified the links between air pollution exposure and cardiometabolic disease and death in Delhi. In addition, three students earned master’s degrees from HSPH and one earned a Doctor of Public Health (DrPH). The proposed project will focus on training early career faculty and researchers and recent post-docs in designing a research study, writing up a proposal, and carrying out research on topics related to the research aims of characterizing the exposome and identifying groups most vulnerable to the effects of air pollution. Two additional DrPH students will also be trained. The project will be led by Dr.Sieber and Dr.Schwartz from HSPH and by Dr. Prabhakaran of CCDC and Dr. Reddy of the Public Health Foundation of India who will be assisted by the: 1) Administrative Oversight Committee; 2) Training Oversight Committee; 3) Program coordination personnel at HSPH and CCDC; and 4) Supervisory teams to provide oversight for individual trainees. Evidence from the research conducted under the linked U01 will directly inform Indian government agencies and policy makers on how to reduce air pollution exposures and how to protect the most vulnerable groups to reduce the consequent burden of disease. The proposed training of Indian scientists will build capacity to apply for future funding and to fully understand and address this environmental threat.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $278,856 )
2025	2025	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	9	2/24/2025	NON-COMPETING CONTINUATION	$278,856
														Subtotal = $278,856

Issue Date FY: 2024 ( Subtotal = $272,068 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	8	3/19/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	8	2/28/2024	NON-COMPETING CONTINUATION	$272,068
														Subtotal = $272,068

Issue Date FY: 2023 ( Subtotal = $276,916 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	003	7	2/28/2023	NON-COMPETING CONTINUATION	$276,916
2023	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	6	11/14/2022	COMPETING CONTINUATION	$0
2023	2019	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	5	2/2/2023	NON-COMPETING CONTINUATION	$0
2023	2019	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	002	5	2/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $276,916

Issue Date FY: 2022 ( Subtotal = -$14,352 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	6	6/12/2022	COMPETING CONTINUATION	$256,047
2022	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	002	6	7/10/2022	COMPETING CONTINUATION	$0
2022	2019	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	5	11/28/2021	NON-COMPETING CONTINUATION	-$270,399
														Subtotal = -$14,352

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	5	10/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $300,000 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	5	8/9/2019	NON-COMPETING CONTINUATION	$300,000
2019	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	4	1/14/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,000

Issue Date FY: 2018 ( Subtotal = $300,000 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	4	8/13/2018	NON-COMPETING CONTINUATION	$300,000
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	4	8/17/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,000

Issue Date FY: 2017 ( Subtotal = $300,000 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	002	3	9/22/2017	NON-COMPETING CONTINUATION	$0
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	001	3	9/20/2017	NON-COMPETING CONTINUATION	$0
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	3	9/15/2017	NON-COMPETING CONTINUATION	$300,000
														Subtotal = $300,000

Issue Date FY: 2016 ( Subtotal = $300,000 )
2016	2016	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	2	8/25/2016	NON-COMPETING CONTINUATION	$300,000
														Subtotal = $300,000

Issue Date FY: 2015 ( Subtotal = $300,000 )
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	International Research and Research Training	000	1	9/24/2015	NEW	$300,000
														Subtotal = $300,000

Grand Total All Awards = $2,313,487

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2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US

Award Number: U2RTW010108

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/28/2015

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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