Tuesday, September 30, 2025 9/30/2025

ECHO Coordinating Center (CC) - Kitting Expanded Scope

Award Number: U2COD023375
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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ECHO Coordinating Center (CC) - Kitting Expanded Scope - OVERALL ABSTRACT This supplement will follow the approved Abstract under the ECHO CC U2COD023375-08. Child health is determined by multiple environmental forces; however, surprisingly little is known about the interactions of these forces. In addition, despite an emerging consensus that numerous gene-environment interactions determine child health, much remains unknown about how genetic and environmental factors combine to promote or prevent adverse outcomes. This Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (CC) proposal seeks to further strengthen the broad children’s health research community to increase the body of knowledge about these complicated effects by fostering collaboration among internal and external stakeholders and supporting the research of the ECHO Program to enhance the health of children for generations to come. The Duke Clinical Research Institute (DCRI) is uniquely positioned to serve as the ECHO CC after successfully serving as the ECHO CC for the last seven years. In addition, DCRI manages >30 active network and administrative coordinating centers and has emerged as a leader in pediatric research. Unique features of the proposed ECHO CC include: 1) extensive experience and track record of the leadership team in the support of the initial ECHO Program and conduct of multiple pediatric studies; 2) pediatric operational expertise of the DCRI; and 3) existing, robust administrative infrastructure necessary to effectively and efficiently manage responsibilities for coordinating the ambitious efforts of the ECHO Program. The team is led by Drs. P. Brian Smith and Linda Adair. The specific aims for the ECHO CC are to: 1) provide organizational infrastructure to coordinate and oversee ECHO Program’s research activities; 2) support ECHO Cohort Committees and communication among all ECHO Program Components and stakeholders; 3) manage the ECHO OIF and foster training of investigators through an inclusive research environment. The ECHO CC will establish and oversee the required infrastructure to coordinate the multiple levels of membership in the ECHO Program. This infrastructure will focus on methods of learning valuable information about environmental exposures through aggregation of massive amounts of data from ECHO Cohort Study Sites. The ECHO CC will make scientific efforts faster and more efficient while protecting human subjects. This infrastructure is possible because of the expertise of DCRI, which not only has extensive experience in coordinating pediatric studies but also has the essential platforms ready.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $26,177,461 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	002	9	7/9/2025	SUPPLEMENT FOR EXPANSION	$7,002,175
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	003	9	9/12/2025	SUPPLEMENT FOR EXPANSION	$5,175,289
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	001	9	6/5/2025	EXTENSION WITH OR WITHOUT FUNDS	$13,999,997
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	000	8	2/13/2025	COMPETING CONTINUATION	$0
														Subtotal = $26,177,461

Issue Date FY: 2024 ( Subtotal = $4,100,000 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	005	8	9/4/2024	SUPPLEMENT FOR EXPANSION	$4,100,000
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	004	8	4/25/2024	COMPETING CONTINUATION	$5,380,654
2024	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	000	7	4/25/2024	NON-COMPETING CONTINUATION	-$1,649,397
2024	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	002	7	4/25/2024	SUPPLEMENT FOR EXPANSION	-$1,999,671
2024	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	003	7	4/25/2024	SUPPLEMENT FOR EXPANSION	-$1,631,709
2024	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	001	7	4/25/2024	SUPPLEMENT FOR EXPANSION	-$99,877
														Subtotal = $4,100,000

Issue Date FY: 2023 ( Subtotal = $28,999,807 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	004	8	9/11/2023	SUPPLEMENT FOR EXPANSION	$999,813
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	003	8	8/22/2023	COMPETING CONTINUATION	$27,999,994
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	005	8	9/15/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	002	7	7/27/2023	NON-COMPETING CONTINUATION	$0
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	7	11/8/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	7	11/4/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $28,999,807

Issue Date FY: 2022 ( Subtotal = $21,588,813 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	003	7	8/24/2022	SUPPLEMENT FOR EXPANSION	$1,999,671
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	7	8/19/2022	NON-COMPETING CONTINUATION	$17,857,556
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	002	7	8/22/2022	SUPPLEMENT FOR EXPANSION	$99,877
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	004	7	9/9/2022	SUPPLEMENT FOR EXPANSION	$1,631,709
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	6	6/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $21,588,813

Issue Date FY: 2021 ( Subtotal = $19,002,857 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	002	6	9/16/2021	NON-COMPETING CONTINUATION	$0
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	6	9/14/2021	SUPPLEMENT FOR EXPANSION	$1,500,000
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	6	9/13/2021	NON-COMPETING CONTINUATION	$17,502,857
														Subtotal = $19,002,857

Issue Date FY: 2020 ( Subtotal = $21,970,707 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	5	9/10/2020	NON-COMPETING CONTINUATION	$14,970,707
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	002	5	9/11/2020	SUPPLEMENT FOR EXPANSION	$7,000,000
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	4	9/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $21,970,707

Issue Date FY: 2019 ( Subtotal = $14,603,592 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	4	9/24/2019	SUPPLEMENT FOR EXPANSION	$6,750,000
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	4	9/10/2019	NON-COMPETING CONTINUATION	$7,853,592
														Subtotal = $14,603,592

Issue Date FY: 2018 ( Subtotal = $15,926,881 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	3	9/7/2018	NON-COMPETING CONTINUATION	$999,076
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	003	3	9/21/2018	NON-COMPETING CONTINUATION	$411,113
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	3	8/31/2018	NON-COMPETING CONTINUATION	$13,846,811
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	002	3	9/13/2018	NON-COMPETING CONTINUATION	$669,881
														Subtotal = $15,926,881

Issue Date FY: 2017 ( Subtotal = $18,172,311 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	2	9/14/2017	NON-COMPETING CONTINUATION	$850,000
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	2	9/1/2017	NON-COMPETING CONTINUATION	$17,322,311
														Subtotal = $18,172,311

Issue Date FY: 2016 ( Subtotal = $14,811,259 )
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	1	9/21/2016	NEW	$14,763,526
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	1	9/23/2016	NEW	$47,733
														Subtotal = $14,811,259

Grand Total All Awards = $185,353,688

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ECHO Coordinating Center (CC) - Kitting Expanded Scope

Award Number: U2COD023375

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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