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Mount Sinai HHEAR Network Targeted Lab Hub

Award Number: U2CES026561
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/12/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Mount Sinai HHEAR Network Targeted Lab Hub - Overall PROJECT SUMMARY/ABSTRACT The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Resource (HHEAR) Laboratory Network Hub (formerly known as “CHEAR” in grant cycle 1). We will measure targeted chemical exposures across all life stages to help NIH funded researchers determine how the environment affects human health, development and risk of disease across the life span. In the last 3 years we have expanded our laboratory resources to include liquid handlers to automate sample prep/aliquoting and worked with data scientist to automate data processing to speed the pace of our jobs. In addition we doubled the number of mass spectrometers from 7 to 14 and hired additional faculty all in preparation for this renewal application. We will leverage our substantial institutional investments, including our new 30 million dollar Institute for Exposomics, to serve the HHEAR Lab network and its NIH researcher clients. Our targeted resource will analyze common exposure biomarkers (metals, pesticides, flame retardants, endocrine disrupting chemicals, tobacco metabolites, vitamins, nutritional status, minerals, and other organic compounds) using state-of-the-art analytical methodologies, while developing new biomarkers of chemical exposure based on the needs of our NIH clients. We will further build upon our work in CHEAR in which we created a suite of customizable panels that facilitate research in complex chemical mixtures. Our Developmental core will build upon its highly successful work in creating novel methods to measure current and past chemical exposures in novel biological matrices (e.g. teeth, hair, dried blood spots, placenta) and develop new assays that arise from hits from HHEAR's untargeted and environmental resources. This team already developed methods to objectively reconstruct past chemical exposures and identify susceptibility windows as they relate to human health in CHEAR. Our Administrative Core will coordinate planning and communication internally among all Hub components and externally with the HHEAR Coordinating Center, Data Center and the other HHEAR Network Hubs. Internally, the Administrative Core will streamline and prioritize HHEAR jobs, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day to day operations. Our Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications guiding them to exposures that fit the most up to date and innovative environmental health science. If necessary we will outreach to outside laboratories with analytic capabilities/expertise that do not reside in our Lab Hub. In conclusion, this proposal links highly experienced environmental health scientists with physicians, toxicologists, stress researchers, chemists, exposure scientists, epidemiologists, and computer scientists to build the infrastructure and capacity to objectively measure human environments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $500,950 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	001	8	6/6/2025	NON-COMPETING CONTINUATION	$500,950
2025	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	6	10/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $500,950

Issue Date FY: 2024 ( Subtotal = $1,661,208 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	7	6/12/2024	EXTENSION WITH OR WITHOUT FUNDS	$1,661,208
														Subtotal = $1,661,208

Issue Date FY: 2023 ( Subtotal = $2,429,619 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	003	6	5/31/2023	NON-COMPETING CONTINUATION	$2,300,001
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	004	6	8/2/2023	SUPPLEMENT FOR EXPANSION	$129,618
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	5	12/9/2022	NON-COMPETING CONTINUATION	$0
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	002	5	4/10/2023	NON-COMPETING CONTINUATION	$0
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	001	5	3/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,429,619

Issue Date FY: 2022 ( Subtotal = $2,300,001 )
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	5	7/6/2022	NON-COMPETING CONTINUATION	$2,300,001
														Subtotal = $2,300,001

Issue Date FY: 2021 ( Subtotal = $2,537,734 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	4	6/2/2021	NON-COMPETING CONTINUATION	$2,537,734
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	002	4	6/7/2021	NON-COMPETING CONTINUATION	$0
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	001	4	6/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,537,734

Issue Date FY: 2020 ( Subtotal = $2,300,001 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	004	3	9/16/2020	SUPPLEMENT FOR EXPANSION	$1,000,000
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	003	3	6/19/2020	NON-COMPETING CONTINUATION	$0
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	002	3	5/28/2020	NON-COMPETING CONTINUATION	$1,300,001
2020	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	001	2	2/1/2020	COMPETING CONTINUATION	$566,382
2020	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Trans-NIH Research Support	000	1	2/1/2020	SUPPLEMENT FOR EXPANSION	-$566,382
														Subtotal = $2,300,001

Issue Date FY: 2019 ( Subtotal = $1,300,001 )
2019	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Environmental Health	000	2	9/4/2019	COMPETING CONTINUATION	$1,300,001
														Subtotal = $1,300,001

Issue Date FY: 2017 ( Subtotal = $703,319 )
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Trans-NIH Research Support	000	1	9/19/2017	SUPPLEMENT FOR EXPANSION	$703,319
														Subtotal = $703,319

Issue Date FY: 2016 ( Subtotal = $400,000 )
2016	2016	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Trans-NIH Research Support	000	1	9/21/2016	SUPPLEMENT FOR EXPANSION	$400,000
														Subtotal = $400,000

Issue Date FY: 2015 ( Subtotal = $10,400,000 )
2015	2015	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Trans-NIH Research Support	000	1	9/24/2015	NEW	$10,400,000
														Subtotal = $10,400,000

Grand Total All Awards = $24,532,833

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Mount Sinai HHEAR Network Targeted Lab Hub

Award Number: U2CES026561

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/12/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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