Wednesday, February 5, 2025
2/5/2025
PROJECT SUMMARY/ABSTRACT Stroke is a leading cause of disability and mortality with risk stratification based on socioeconomic status and race/ethnicity. The New York City Collaborative Regional Coordinating Center (NYCC-RCC) will unite three complementary research-intensive biomedical institutions (Einstein, NYU, Mount Sinai), three organizationally linked partners, and a network of high-volume clinical performance sites to further Stroke Net’s mission and to reduce the disproportionate burden of stroke in vulnerable and under-served populations. The NYCC-RCC has a record of leadership in community engagement and partnerships that will facilitate high-risk and under-studied patients’ enrollment in Stroke Net trials. The NYCC-RCC has significant expertise in the conception, development, and execution of clinical trials. The revamped NYCC-RCC will utilize a number of key design features to fulfill Stroke Net’s mission, including: 1) Organizational diversity through the integration of three leading academic health systems with targeted organizationally linked partners and clinical performance sites enhancing specific focus areas; 2) Recruitment and retention of underrepresented populations through com- munity engagement and strategic partnerships; 3) Focus on vulnerable pediatric stroke patients by integrating established pediatric stroke leadership with centers of excellence treating diseases known to confer high stroke risk; 4) Coordination of multiple high-volume thrombectomy centers to facilitate STEP platform enroll- ment; 5) Establishment of programs/infrastructure to facilitate hyper-acute stroke trial participation; 6) Comple- mentary, multidimensional MPI structure including an imbedded career development program; 7) A structured trial development process coupled with senior trialist guidance to generate a pipeline of Stroke Net trial sub- missions; 8) Pre-clinical expertise in evolving translational areas, including epigenetic and regenerative/stem cell therapeutic applications; 9) RCC connectivity via an advanced information technology and network perfor- mance group (IT/NPG). The NYCC-RCC will employ an integrated mentorship model to ensure career devel- opment of promising stroke investigators, including a structured education plan for StrokNet fellows utilizing the breadth and sophistication of our CTSA’s educational curriculums. The NYCC-RCC will train junior and mid-career investigators, as well as clinical research coordinators, toward productive careers in stroke re- search. In summary, the NYCC-RCC will leverage established clinical trials expertise with extensive scientific and organizational excellence to fulfill the Stroke Net’s mission. Therefore, this proposal seeks funding for an NIH Stroke Net – Regional Coordinating Stroke Center U24 – RFA-NS-23-010.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).