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A harmonized vendor-agnostic environment for multi-site functional MRI studies

Award Number: U24NS120056
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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A harmonized vendor-agnostic environment for multi-site functional MRI studies - Since its invention in the early 90s, functional magnetic resonance imaging (fMRI) has revolutionized our un- derstanding of the human brain. Functional MRI may be used to observe brain function during a speciﬁc motor or cognitive task, or at “rest” (resting-state fMRI). The latter produces so-called “functional connectivity” maps that may provide a new window into human cognition. There is currently a large, world-wide effort underway to discover potential research and clinical uses of such connectivity maps. A signiﬁcant practical barrier in this effort, however, is the difﬁculty in ensuring that fMRI experiments are conducted in a consistent and reproducible manner across different centers. In particular, it is generally not possible to ensure identical execution of MR measurements (pulse sequences) across sites operating different MR scanners. Furthermore, even the image reconstruction and data processing methods can be difﬁcult to harmonize, particularly across different MR ven- dors. This makes it challenging to directly compare results between sites, or “pool” data from multiple sites to increase statistical power and gain access to rare clinical conditions. We will assemble and disseminate a truly harmonized, cross-vendor, and ﬂexible environment for fMRI re- search that ensures consistent data acquisition and image reconstruction across sites. Our framework is based on an open-source MR sequence development platform that allows any arbitrary MR pulse sequence to be de- signed “off-line” in Matlab or Python and exported to a vendor-independent ﬁle format, that can be ported directly to scanners from different manufacturers (at present, General Electric and Siemens are supported, but others may follow in the future). Due to this open pulse sequence structure it will also be possible to compose a uniﬁed image reconstruction environment based on current open-source libraries. Based on this technology, we will provide the fMRI research community with a complete and portable workﬂow for fMRI data acquisition and image reconstruction, backed up by integrated quality control procedures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $551,871 )
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/27/2026	NON-COMPETING CONTINUATION	$380,169
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	21st Century Cures Act -Brain Research through Advancing Innovative Neurotechnologies	002	5	8/12/2026	SUPPLEMENT FOR EXPANSION	$171,702
2026	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/10/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $551,871

Issue Date FY: 2025 ( Subtotal = $614,927 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/9/2025	NON-COMPETING CONTINUATION	$417,557
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/13/2025	SUPPLEMENT FOR EXPANSION	$197,370
														Subtotal = $614,927

Issue Date FY: 2024 ( Subtotal = $625,796 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/12/2024	NON-COMPETING CONTINUATION	$625,796
														Subtotal = $625,796

Issue Date FY: 2023 ( Subtotal = $926,705 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/30/2023	NON-COMPETING CONTINUATION	$926,705
														Subtotal = $926,705

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/3/2022	NEW	$0
2022	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/9/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $555,791 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/7/2021	NEW	$555,791
														Subtotal = $555,791

Grand Total All Awards = $3,275,090

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A harmonized vendor-agnostic environment for multi-site functional MRI studies

Award Number: U24NS120056

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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