Thursday, November 21, 2024
11/21/2024
ABSTRACT The Western NC Stroke Net Regional Coordinating Center (RCC) has been a high-performing site since 2018, with 206 participants enrolled (as of 1/17/23) in 12 of 13 ongoing trials, 85% retention of diverse participants (28% African American, 2.5% American Indian/Alaska Native), and trials that were launched quickly (average 105 days from activation to first subject randomized, shortest time 7 days). We are a top enroller for MOST (20), SATURN (11), and ASPIRE (7). Our Career Enhancement and Training Program has successfully trained 3 academically productive fellows, with 11 publications, 32 presentations at scientific meetings, and recognition by the NCC Education Core. In 2020, Wake Forest Baptist merged with Atrium Health, and in 2022, Advocate Aurora merged with Atrium to become the 2nd largest health system in the US with a medical school (WFUSM is the academic core). With expansion of our network, we are now the Wake Forest Stroke Net. The clinical performance sites for this renewal include Atrium Health Wake Forest Baptist (RCC), Novant Forsyth Medical Center, Atrium Health Carolinas Medical Center (Charlotte), Carolinas Rehab (Charlotte), Eastern Carolina University (Greenville, NC), Novant New Hanover Regional Medical Center (Wilmington, NC), Advocate Christ Hospital (Chicago), and Aurora St. Luke's Medical Center (Milwaukee). Our catchment includes the majority of NC including the Stroke Buckle, much of the Stroke Belt (SC, GA, AL), and urban cities in WI and IL (over 6,500 stroke patients discharged in 2022), covering populations from diverse socioeconomic, urban and rural geographies, typically under-represented in clinical trials. Wake Forest investigators have designed and conducted first-in-human, phase II, III, pragmatic, and comparative effectiveness trials. We have diverse, experienced stroke leadership at the RCC, with Dr. Bushnell (neurology) and Dr. Wolfe (vascular neurosurgery) as MPIs, and Drs. Ranasinghe and Baldwin (both Neurology) as co-Is, as well as a seasoned Stroke Net project manager, Krystal Schmidt, who will assist the partnering sites with trial selection, startup, and operations to meet the goals of efficiency and enrollment with Stroke Net clinical trials. We have partnered with a successful community outreach program (Triad Pastor's Network) and added a Patient and Participant Advisory Board that will review protocols, consents, and trial performance. Our goal is to be the leading SN RCC enrolling primarily in the Southeast US, with diverse stroke patients into SN trials, bringing important scientific discoveries to the SN network. We will achieve the following: AIM 1: To continue and expand successful enrollment and retention of participants in Stroke Net trials from our geographically, ethnically, economically, and historically underserved diverse catchment areas. AIM 2: To collaborate with our interdisciplinary team to design and propose new Stroke Net treatment, prevention, recovery trials. AIM 3: To continue to train the next generation of diverse stroke clinical trialists and researchers. AIM 4: Develop community outreach programs to engage rural and urban communities in our expanded referral regions in Stroke Net trials.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
