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DMCC for ME/CFS CCR: Recompete 2022

Award Number: U24NS105535
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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DMCC for ME/CFS CCR: Recompete 2022 - PROJECT SUMMARY/ABSTRACT The Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRCs) Network was created in 2017 to foster multidisciplinary research to inform the etiology, pathogenesis, and treatment of ME/CFS, a debilitating, complex, multisystem disorder that affects approximately 0.9% of the population worldwide. Although researchers have identified multiple hypotheses for disease etiology and differential patterns in biological processes, the underlying mechanisms that trigger ME/CFS symptoms and their treatment remain unknown. During the next cycle of the Network, a comprehensive approach is needed to (1) identify subtypes of ME/CFS based on biological markers and symptom classifications, (2) conduct longitudinal studies to understand the time course of disease and its manifestations, (3) develop and validate outcome measures for future intervention trials, and (4) identify potential treatment targets. To support these studies, the Data Management and Coordinating Center (DMCC) will serve as a foundational resource to the CRCs by providing (1) expertise in patient-centered research, data processing, and analysis; (2) communication and social media tools to actively engage the broader ME/CFS community (e.g., ME/CFS patients, clinicians, researchers); and (3) real-time study status dashboards to monitor CRC recruitment and retention and track study progress. In addition, as the Network’s current DMCC, RTI is uniquely positioned to facilitate data mining/integration and clinical data and biospecimen sharing within and outside the Network by expanding the capabilities and reach of our publicly available online ME/CFS research tools mapMECFS and searchMECFS. Specifically, the DMCC will continue to support the endeavors of the Network and the CRCs and enhance our research tools to help define the cause(s) of ME/CFS and discover better diagnostics and treatment to improve the health outcomes for individuals with ME/CFS by accomplishing our three specific aims. Aim 1. Enable novel discovery through collaborative science by expanding the content, userbase, and functionality of the mapMECFS data sharing portal. Aim 2. Advance ME/CFS research through our secure online data portal with enhanced data collection, data sharing, and clinical/biospecimen linkage tools. Aim 3. Promote research efficiency and foster collaboration and coordination by enhancing communication with ME/CFS internal and external partners and providing logistical and administrative support to the CRCs. The DMCC will be co-led by multiple Principal Investigators (mPIs) Linda Morris Brown, MPH, DrPH, and Matthew Schu, PhD. Together they bring 58 years of experience in multisite consortia coordination, project management, conducting and monitoring of observational studies, web-based data collection instruments, specimen collection, publication of results, and sharing of de-identified data. Our mPI leadership model pairing a senior epidemiologist, Dr. Brown, with a senior bioinformatician, Dr. Schu, will continue to be key to our success in effectively spanning the clinical, scientific, and technical needs of the Network.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,107,404 )
2025	2025	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	3/7/2025	SUPPLEMENT FOR EXPANSION	$63,932
2025	2025	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	8	6/5/2025	NON-COMPETING CONTINUATION	$1,043,472
2025	2024	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	1/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,107,404

Issue Date FY: 2024 ( Subtotal = $868,249 )
2024	2024	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	6/28/2024	NON-COMPETING CONTINUATION	$868,249
2024	2023	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	7/1/2024	COMPETING CONTINUATION	$0
2024	2023	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	5/6/2024	COMPETING CONTINUATION	$99,657
2024	2022	RESEARCH TRIANGLE INSTITUTE	3040 CORNWALLIS RD	DURHAM	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/6/2024	SUPPLEMENT FOR EXPANSION	-$99,657
														Subtotal = $868,249

Issue Date FY: 2023 ( Subtotal = $908,969 )
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	6/27/2023	COMPETING CONTINUATION	$0
2023	2023	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	6/15/2023	COMPETING CONTINUATION	$908,969
2023	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/14/2023	NON-COMPETING CONTINUATION	$0
2023	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $908,969

Issue Date FY: 2022 ( Subtotal = $99,999 )
2022	2022	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/19/2022	SUPPLEMENT FOR EXPANSION	$99,999
2022	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $99,999

Issue Date FY: 2021 ( Subtotal = $1,123,579 )
2021	2021	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/17/2021	NON-COMPETING CONTINUATION	$1,123,579
2021	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,123,579

Issue Date FY: 2020 ( Subtotal = $1,149,560 )
2020	2020	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	6/16/2020	NON-COMPETING CONTINUATION	$1,149,560
2020	2019	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/31/2020	NON-COMPETING CONTINUATION	$0
2020	2019	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	6/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,149,560

Issue Date FY: 2019 ( Subtotal = $1,176,919 )
2019	2019	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	6/25/2019	NON-COMPETING CONTINUATION	$1,176,919
2019	2018	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/28/2019	NON-COMPETING CONTINUATION	$0
2019	2018	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/9/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,176,919

Issue Date FY: 2018 ( Subtotal = $1,193,851 )
2018	2018	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/3/2018	NON-COMPETING CONTINUATION	$1,193,851
														Subtotal = $1,193,851

Issue Date FY: 2017 ( Subtotal = $1,260,904 )
2017	2017	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2017	NEW	$1,260,904
2017	2017	RESEARCH TRIANGLE INSTITUTE	3040 E CORNWALLIS RD	RESEARCH TRIANGLE PARK	NC	27709	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/25/2017	NEW	$0
														Subtotal = $1,260,904

Grand Total All Awards = $8,889,434

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DMCC for ME/CFS CCR: Recompete 2022

Award Number: U24NS105535

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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