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The NINDS Human Cell and Data Repository (U24 renewal)

Award Number: U24NS095914
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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The NINDS Human Cell and Data Repository (U24 renewal) - NINDS Application Abstract Human induced pluripotent stem cells (hiPSC) derived through epigenetic reprogramming of adult somatic cells were first described in 2007. Since then, hiPSCs have been established from subjects with specific disorders (many with known genotypes) and subsequently differentiated into somatic cell types such as neurons for research into central nervous system disorders. Using these hiPSC we can create “disease models in a dish” to study disease etiology and progression and for toxicology and drug screening. However, human genomic diversity (i.e., variability in genetic background) limits the utility of individual hiPSC for disease modeling in populations. Controls have often consisted of age and sex-matched non-affected family members or other subjects with the same disorder. However, the CRISPR (clustered regularly-interspaced short palindromic repeats) /Cas gene editing system can now generate isogenic hiPSC that will serve as more precise controls to eliminate effects due to genetic background, thus providing a better understanding of disease etiology and development. The NINDS Human Cell and Data Repository (NHCDR) was established to collect, derive and distribute human somatic cells such as skin fibroblasts and blood cells and reprogram these to iPSCs for research on neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, Amyotrophic Lateral Sclerosis, Dystonia, and Frontotemporal Dementia. In 2015, RUCDR Infinite Biologics® (as part of Rutgers University) successfully competed for the NHCDR award, which was competitively renewed in 2019. In 2020, RUCDR became Infinity-Biologix® (IBX), a privately held company (including the Rutgers University Foundation) with significant new resources, added personnel, new equipment and a larger purpose- designed facility, thereby expanding capabilities to include novel cutting-edge technologies and commercial partnerships. IBX received a grant subaward from Rutgers University to conduct all laboratory, storage and distribution operations of the NHCDR. The rebranding of IBX to SAMPLED in 2021 signified a continuation and broadening of its mission to integrate comprehensive biobanking with state-of-the-art analytical, cellular, and sample management services. Since the award renewal in 2019, we have added 28 fibroblast lines from 14 subjects, 214 iPSC lines from 164 subjects and now have 39 genetically modified cells lines from 18 subjects. Since the initiation of the original award in 2015, we have distributed 5573 cell lines through 1426 orders, an average rate of 800 cell lines per year through nearly 200 orders. The continuing mission of the NHCDR is a collaboration with NINDS investigators and program scientific staff on individual study management, which includes collection, processing and distribution of the highest quality cell lines. This effort includes the culturing of fibroblasts from skin biopsies, the isolation of mononuclear cells from blood, and the derivation of iPSC lines from both. SAMPLED and Rutgers will continue to provide a comprehensive range of iPSC quality testing to ensure conformation to the highest standards. If requested, we can provide additional services to the global scientific and commercial community, including the generation of neural stem cells (NSCs) and different types of neurons and organoids. Our efforts will ensure the scientific flexibility and growth of the NHCDR through continuous adaptation to scientific discoveries and evolving best practices in the stem cell field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,339,262 )
2026	2026	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	12	9/3/2026	NON-COMPETING CONTINUATION	$1,339,262
2026	2025	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	4/24/2026	COMPETING CONTINUATION	$0
2026	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	4/15/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,339,262

Issue Date FY: 2025 ( Subtotal = $1,358,854 )
2025	2025	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	11	9/19/2025	COMPETING CONTINUATION	$0
2025	2025	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	8/20/2025	COMPETING CONTINUATION	-$41,146
2025	2025	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	8/13/2025	COMPETING CONTINUATION	$1,400,000
														Subtotal = $1,358,854

Issue Date FY: 2024 ( Subtotal = $1,284,619 )
2024	2024	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	10	9/18/2024	NON-COMPETING CONTINUATION	$1,284,619
2024	2022	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	9/17/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$120,826
2024	2021	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	9/17/2024	NON-COMPETING CONTINUATION	-$120,826
														Subtotal = $1,284,619

Issue Date FY: 2023 ( Subtotal = $1,323,650 )
2023	2023	RUTGERS, THE STATE UNIVERSITY	3 RUTGERS PLZ	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	8/24/2023	NON-COMPETING CONTINUATION	$1,323,650
														Subtotal = $1,323,650

Issue Date FY: 2022 ( Subtotal = $1,313,946 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	9/9/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	8/11/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,313,946
														Subtotal = $1,313,946

Issue Date FY: 2021 ( Subtotal = $1,617,478 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	7	9/22/2021	SUPPLEMENT FOR EXPANSION	$305,242
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	7	7/10/2021	NON-COMPETING CONTINUATION	$1,312,236
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	7/6/2021	COMPETING CONTINUATION	$84,623
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	10/30/2020	COMPETING CONTINUATION	$0
2021	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/6/2021	NON-COMPETING CONTINUATION	-$84,623
														Subtotal = $1,617,478

Issue Date FY: 2020 ( Subtotal = $1,357,826 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	7/30/2020	COMPETING CONTINUATION	$1,321,623
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	9/23/2020	SUPPLEMENT FOR EXPANSION	$36,203
														Subtotal = $1,357,826

Issue Date FY: 2019 ( Subtotal = $1,159,079 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/5/2019	NON-COMPETING CONTINUATION	$1,159,079
														Subtotal = $1,159,079

Issue Date FY: 2018 ( Subtotal = $1,408,872 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	9/20/2018	SUPPLEMENT FOR EXPANSION	$249,793
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/13/2018	NON-COMPETING CONTINUATION	$1,159,079
														Subtotal = $1,408,872

Issue Date FY: 2017 ( Subtotal = $1,156,029 )
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/31/2017	NON-COMPETING CONTINUATION	$1,156,029
														Subtotal = $1,156,029

Issue Date FY: 2016 ( Subtotal = $1,229,492 )
2016	2016	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/26/2016	NON-COMPETING CONTINUATION	$1,175,650
2016	2016	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/20/2016	SUPPLEMENT FOR EXPANSION	$53,842
														Subtotal = $1,229,492

Issue Date FY: 2015 ( Subtotal = $1,384,486 )
2015	2015	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLAZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/24/2015	NEW	$1,384,486
														Subtotal = $1,384,486

Grand Total All Awards = $15,933,593

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The NINDS Human Cell and Data Repository (U24 renewal)

Award Number: U24NS095914

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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