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Biospecimen Exchange for Neurological Disorders (BioSEND)

Award Number: U24NS095871
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Biospecimen Exchange for Neurological Disorders (BioSEND) - PROJECT SUMMARY/ABSTRACT We have prepared this application in response to RFA-NS-20-031, which invites applicants to serve as the NINDS Human Biospecimen and Data Repository in Neurological Disorders. The BioSpecimen Exchange for Neurological Disorders (BioSEND) was awarded to Indiana University on September 30, 2015. This application proposes to renew and retain BioSEND at Indiana University and expand the impact and success of BioSEND through additional innovations and improvements. With the transfer of the NINDS-funded biorepository to Indiana University, BioSEND dramatically expanded the number of disorders for which samples are banked. The scope and scale of banking has also dramatically increased with the establishment of BioSEND at Indiana University. The value of the biospecimens banked at BioSEND is demonstrated by the substantial growth in the requests for these samples by researchers. Over the past five years, BioSEND has made 93 distributions to 42 investigators at more than 30 institutions. Indiana University has developed a strong biorepository team consisting of faculty with critical scientific and leadership experience and staff with essential expertise in biobanking, clinical research coordination, and data management. Over the past five years, we have developed a strong infrastructure and implemented a customer- focused approach that employs innovative solutions to both specimen banking and distribution. Based on our success in establishing a widely used biospecimen repository, we plan further improvements and expansion of BioSEND to meet the NINDS mission to increase biobanking to support basic, translational and clinical research in neurological disorders. We propose to pursue the following specific aims for the next five years: Aim 1: Provide leadership to BioSEND Aim 2: Provide study management expertise Aim 3: Provide scientific and laboratory expertise Aim 4: Distribute samples to approved researchers Aim 5: Develop custom solutions to link clinical data with biospecimens


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,801,906 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	7/17/2024	NON-COMPETING CONTINUATION	$1,801,906
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,801,906

Issue Date FY: 2023 ( Subtotal = $1,865,185 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	8	7/11/2023	NON-COMPETING CONTINUATION	$1,865,185
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	5/2/2023	NON-COMPETING CONTINUATION	$0
2023	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	11/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,865,185

Issue Date FY: 2022 ( Subtotal = $1,864,635 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	006	7	8/4/2022	NON-COMPETING CONTINUATION	$0
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	7	8/1/2022	NON-COMPETING CONTINUATION	$1,864,635
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	1/12/2022	COMPETING CONTINUATION	$543,391
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	12/11/2021	COMPETING CONTINUATION	$543,391
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	6	4/6/2022	COMPETING CONTINUATION	$0
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	1/12/2022	COMPETING CONTINUATION	-$543,391
2022	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/7/2021	NON-COMPETING CONTINUATION	-$543,391
														Subtotal = $1,864,635

Issue Date FY: 2021 ( Subtotal = $1,499,999 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	7/9/2021	COMPETING CONTINUATION	$1,499,999
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	7/21/2021	COMPETING CONTINUATION	$0
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/25/2020	NON-COMPETING CONTINUATION	$0
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/6/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,499,999

Issue Date FY: 2019 ( Subtotal = $1,385,734 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/6/2019	NON-COMPETING CONTINUATION	$1,385,734
														Subtotal = $1,385,734

Issue Date FY: 2018 ( Subtotal = $1,390,905 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	9/12/2018	NON-COMPETING CONTINUATION	$1,390,905
														Subtotal = $1,390,905

Issue Date FY: 2017 ( Subtotal = $1,410,233 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/19/2017	NON-COMPETING CONTINUATION	$1,410,233
														Subtotal = $1,410,233

Issue Date FY: 2016 ( Subtotal = $1,459,432 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/6/2016	NON-COMPETING CONTINUATION	$1,459,432
														Subtotal = $1,459,432

Issue Date FY: 2015 ( Subtotal = $1,500,000 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2015	NEW	$1,500,000
														Subtotal = $1,500,000

Grand Total All Awards = $14,178,029

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Biospecimen Exchange for Neurological Disorders (BioSEND)

Award Number: U24NS095871

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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