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National Brain and Tissue Resource for Parkinson's Disease and Related Disorders

Award Number: U24NS072026
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2011
PERIOD OF PERFORMANCE END DATE: 09/30/2016

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National Brain and Tissue Resource for Parkinson's Disease and Related Disorders - DESCRIPTION (provided by applicant): Parkinson's disease (PD) and related Lewy body disorders (LBD), including incidental Lewy body disease (ILDB), Alzheimer's disease with Lewy bodies (ADLB) and dementia with Lewy bodies (DLB) may affect up to 40% of the elderly population. Current FDA-approved therapies for PD are still based on neurochemical deficits discovered more than 40 years ago. Experimental model-systems and molecular genetics research since that time, while contributing exponentially to the knowledge base, have not converted this work into new approved agents. Renewed and intensified human tissue-based research may help break this stalemate. Essential to such studies, however, is the availability of high quality diseased and normal control tissue with maximal preservation of molecular entities and detailed clinical characterization. The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute is uniquely suited to fill this critical need, as demonstrated by its 20 years of operation and a median 2.8 hour postmortem interval (PMI) for the entire collection of 1,200 brains. Other unique features include a focus on normal aging, comprehensive standardized antemortem cognitive, motor and non-motor assessments and the accompanying donation of bodily organs. The BBDP has the proven capability of serving as a national resource. In the most recent 5 year period it has supported 91 different researchers located in 20 different states, collectively holding 126 NIH grants. There is no other brain bank in the US or world with these unique capabilities. This proposal would enable the BBDP to become a powerful resource for researchers focused on PD and related disorders. The Specific Aims are directed at supporting a major expansion of service to researchers investigating PD and other LBDs. To accomplish this, resource availability will be publicized, additional staff will be hired and a web portal will be developed so that external researchers may search for and request tissue as well as linked clinical data. Steering and Resources Committees with external investigator representation will manage the resource and evaluate requests, allowing the BBDP to supply between 50 and 100 LBD-focused research projects over the five year funding period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$403,192 )
2017	2015	BANNER HEALTH	2901 N CENTRAL AVE	PHOENIX	AZ	85012	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	2/28/2017	NON-COMPETING CONTINUATION	-$2,153
2017	2015	BANNER HEALTH	2901 N CENTRAL AVE	PHOENIX	AZ	85012	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/14/2017	NON-COMPETING CONTINUATION	-$401,039
														Subtotal = -$403,192

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/27/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $1,608,026 )
2015	2015	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/11/2015	NON-COMPETING CONTINUATION	$1,608,026
														Subtotal = $1,608,026

Issue Date FY: 2014 ( Subtotal = $1,594,500 )
2014	2014	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	9/24/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,594,500
														Subtotal = $1,594,500

Issue Date FY: 2013 ( Subtotal = $1,488,864 )
2013	2013	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/16/2013	NON-COMPETING CONTINUATION	$1,488,864
														Subtotal = $1,488,864

Issue Date FY: 2012 ( Subtotal = $1,601,398 )
2012	2012	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/24/2012	NON-COMPETING CONTINUATION	$1,601,398
														Subtotal = $1,601,398

Issue Date FY: 2011 ( Subtotal = $1,460,934 )
2011	2011	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/26/2011	NEW	$1,460,934
														Subtotal = $1,460,934

Grand Total All Awards = $7,350,530

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National Brain and Tissue Resource for Parkinson's Disease and Related Disorders

Award Number: U24NS072026

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2011

PERIOD OF PERFORMANCE END DATE: 09/30/2016

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