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Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data

Award Number: U24MH130968
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data - PROJECT SUMMARY This project will create scalable resources that will be critical to the development of BRAIN Initiative Cell Atlas Network (BICAN) consortium brain atlases. This team will focus on the development of common molecular data processing pipelines that are cloud-native and FAIR. Starting with an already established portfolio of BICCN pipelines and community relationships developed in previous funding, this portfolio will be updated and extended in collaboration with the BICAN community. Leveraging and improving existing integration between the BICCN molecular (NeMO) archive and cloud-computing environment (Terra), this team will process data sets, prioritized by the BICAN community and in support of joint analysis for atlas building. These pipelines will produce data with a comprehensive panel of metrics that our team will leverage to perform quality control and assure rigor in data processing and use. This team will work with analysis groups to confirm outputs of the pipelines are compatible with downstream analysis and are extended to incorporate critical downstream steps as they mature and are agreed upon by the BICAN community. The cloud computing environment used by this team will be open and available to the BICAN community and supported by a helpdesk, documentation, forums, and an annual workshop. As this infrastructure spans institutes, Terra is currently enabling BICCN working groups to share cloud resources and jointly analyze data in a common scalable space; this will continue to be true in the BICAN community. To enable visualizing, sharing and publishing of data, this team brings cloud programming environments (Terra), specialized scalable resources (Cirrocumulus, Pegasus), and publication portals (NeMO Analytics, and the Single Cell Portal) to be leveraged in consortium activities. These common resources will be critical to enable the BICAN community to come together and perform analysis that scales to the needs of BICAN atlas building efforts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,549,951 )
2026	2026	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	5	8/3/2026	NON-COMPETING CONTINUATION	$1,549,951
2026	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	4	6/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,549,951

Issue Date FY: 2025 ( Subtotal = $1,757,645 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	4	9/11/2025	NON-COMPETING CONTINUATION	$1,554,194
2025	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	3	4/22/2025	NON-COMPETING CONTINUATION	$203,451
														Subtotal = $1,757,645

Issue Date FY: 2024 ( Subtotal = $1,558,314 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	001	3	8/13/2024	NON-COMPETING CONTINUATION	$1,558,314
2024	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	2	11/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,558,314

Issue Date FY: 2023 ( Subtotal = $1,718,474 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	2	6/26/2023	NON-COMPETING CONTINUATION	$1,718,474
														Subtotal = $1,718,474

Issue Date FY: 2022 ( Subtotal = $1,764,788 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Mental Health Research Grants	000	1	8/18/2022	NEW	$1,764,788
														Subtotal = $1,764,788

Grand Total All Awards = $8,349,172

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Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data

Award Number: U24MH130968

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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