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Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center

Award Number: U24MH124629
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center - The “clinical high risk” (CHR) for psychosis syndrome is an antecedent period characterized by attenuated psychotic symptoms that are marked by subtle deviations from normal development in thinking, motivation, affect, behavior, and a decline in functioning. Early intervention in this CHR population is critical to prevent psychosis onset as well as other adverse outcomes. However, the presentation of symptoms and subsequent course is highly variable, and there is a paucity of biomarkers to guide treatment development. Thus, to improve predictive models that are clinically relevant, several issues need to be addressed: 1) focusing on outcomes beyond psychosis; 2) taking into account heterogeneity in samples and outcomes; and 3) integrating data sets with a broad array of variables using innovative algorithms to overcome variability across studies. To address these challenges, the proposed “Psychosis Risk Evaluation Data Integration and Computational Technologies: Data Processing, Analysis, and Coordination Center” (PREDICT-DPACC) brings together a multidisciplinary team of highly experienced researchers with proven capabilities in all aspects of large-scale studies, CHR studies, as well as computational expertise. The ultimate goal is to identify new CHR biomarkers, and CHR subtypes that will enhance future clinical trials. To do so, the PREDICT-DPACC will 1) aggregate extant CHR- related data sets from legacy datasets; 2) provide collaborative management, direction, data processing and coordination for new U01 multisite network(s); and 3) develop and apply advanced algorithms to identify biomarkers that predict outcomes, and to stratify CHR into subtypes based on outcome trajectories, first from the extant data and then refined and applied to the new data. The PREDICT-DPACC team has the broad, comprehensive, and robust infrastructure that is sufficiently flexible to accommodate the inclusion of multiple data types and to optimally address the needs of the CHR U01 network(s). Carefully selected extant data will be rapidly obtained, processed, and uploaded to the NIMH Data Archive (NDA). Proposed analysis methods are powerful and robust, leveraging the expertise and experience of computer scientist developers, and experienced clinical researchers. The U01 network(s) will be coordinated by a team that is experienced in managing large studies, familiar with the needs of such studies, flexible, and is knowledgeable in all aspects of CHR studies, including measures, outcomes, biomarkers, and cohorts. Upon meeting the goals of this U24, and the supported U01 network(s), the expected outcomes of the PREDICT-DPACC will be new predictive biomarkers for CHR outcomes, new definitions of CHR subtypes that are clinically useful, and new curated and comprehensive CHR datasets (extant and new) as well as processing tools and prediction algorithms that are shared with the research community through the NIMH Data Archive.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	5	4/25/2025	NON-COMPETING CONTINUATION	$0
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	5	12/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $6,915,397 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	5	5/13/2024	NON-COMPETING CONTINUATION	$6,915,397
														Subtotal = $6,915,397

Issue Date FY: 2023 ( Subtotal = $7,027,553 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	002	4	9/5/2023	SUPPLEMENT FOR EXPANSION	$2,353,360
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	4	5/16/2023	NON-COMPETING CONTINUATION	$4,674,193
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	4	6/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,027,553

Issue Date FY: 2022 ( Subtotal = $4,684,676 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	3	5/12/2022	NON-COMPETING CONTINUATION	$4,684,676
														Subtotal = $4,684,676

Issue Date FY: 2021 ( Subtotal = $4,695,182 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	003	2	9/14/2021	SUPPLEMENT FOR EXPANSION	$777,372
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	002	2	5/24/2021	NON-COMPETING CONTINUATION	$3,917,810
2021	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	1/22/2021	NEW	$0
2021	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	1	2/18/2021	NEW	$0
														Subtotal = $4,695,182

Issue Date FY: 2020 ( Subtotal = $3,935,239 )
2020	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	9/8/2020	NEW	$3,935,239
														Subtotal = $3,935,239

Grand Total All Awards = $27,258,047

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Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center

Award Number: U24MH124629

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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