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2/2 Women's Aneurysm Research: Repair Immediately Or Routine Surveillance: WARRIORS trial

Award Number: U24HL181192
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2032

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2/2 Women's Aneurysm Research: Repair Immediately Or Routine Surveillance: WARRIORS trial - PROJECT SUMMARY Abdominal Aortic Aneurysm (AAA) repair is typically recommended when the aneurysm diameter reaches 5.5 cm, based on studies that primarily included men. Women, however, face a fourfold higher risk of AAA rupture at smaller diameters and nearly double the mortality following surgery. This discrepancy raises critical questions about whether women should undergo elective AAA repair at smaller diameters than men to improve survival and quality of life. The WARRIORS trial (Women’s Aneurysm Research: Repair Immediately Or Routine Surveillance) is an international, randomized controlled trial designed to address this issue by comparing early elective endovascular aortic repair (EVAR) with routine surveillance in women aged 50+ with small (4.0-5.4 cm) asymptomatic AAAs suitable for EVAR. The trial will enroll 1,112 women globally, including 350 in the United States, with 1:1 randomization stratified by age, country, and aneurysm size. The primary outcome is AAA-related mortality and rupture over five years, while secondary outcomes include quality-adjusted life years (QALYs), operative mortality, loss of EVAR eligibility, and cost-effectiveness. The trial’s innovative design incorporates registry-supported data collection, novel electronic health record screening for patient identification, and extensive patient and community engagement to ensure broad representation and minimal loss to follow-up. The trial meets criteria for NHLBI’s strategic goals and objectives i.e. Objective 3: Investigate factors that account for differences in health among populations. By determining whether women should have different criteria for AAA repair, the WARRIORS trial aims to establish sex-specific clinical guidelines, ultimately advancing and improving outcomes for women with AAAs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $157,520 )
2026	2026	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	2	9/17/2026	NON-COMPETING CONTINUATION	$157,520
2026	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	9/3/2026	NEW	$0
														Subtotal = $157,520

Issue Date FY: 2025 ( Subtotal = $318,167 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	9/5/2025	NEW	$318,167
														Subtotal = $318,167

Grand Total All Awards = $475,687

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2/2 Women's Aneurysm Research: Repair Immediately Or Routine Surveillance: WARRIORS trial

Award Number: U24HL181192

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2032

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