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Implementation Research Strategies for Heart, Lung, and Blood Co-morbidities in People Living with HIV - Research Coordinating Center

Award Number: U24HL154426
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Globally, there were an estimated 36.9 million people living with HIV in 2017. As a result of the increased availability of antiretroviral therapy, life expectancy for these patients has increased, resulting in an expansion and aging of the HIV-infected population. Data from both high- and low-resource countries have shown an escalating burden of heart, lung, blood, and sleep (HLBS) disorders among HIV patients. Care for this now aging cohort requires modifying service delivery models towards the prevention, diagnosis, treatment, and control of chronic HLBS disorders. The successful implementation of various solutions developed in response to the global HIV/AIDS pandemic can serve as the foundation to transform global healthcare delivery systems towards HLBS disorder care. The overarching goals of this Research Coordinating Center are: (1) provide scientific, organizational, statistical, quality control, capacity building and operational leadership for the Implementation Science projects to be funded by the companion RFA-HL-20-025 and (2) promote and teach Implementation Research strategies to advance collaborative dialogue across projects and ensure up-to-date conceptualization, specification and measurement of implementation strategies and outcomes. In support of these goals, we have assembled a highly experienced and multidisciplinary research team. Our team, with expertise in running multicenter trials, dissemination and implementation research, biostatistics and research design, HIV, HLBS disorders, capacity building, and data management, will pursue the following specific aims: 1. To oversee management, organizational, and communication activities across all research sites including working with NHLBI to prepare meeting agendas, develop the study website, provide administrative support for research projects, and organize face-to-face meetings. 2. To collaborate with all research sites in developing the scientific and operational details of their implementation science research protocols. These efforts will include: a. Assisting study sites in designing, testing, and maintaining password protected data entry and management systems and ensuring that such systems implement robust quality control features. b. Harmonizing (a) demographic, clinical, and questionnaire measurements across research sites and (b) the conceptualization and measurement of implementation strategies and implementation outcomes. c. In collaboration with research sites, to statistically analyze harmonized data and to assist in the analysis of site-specific data as reports, manuscripts, and abstracts are prepared. 3. To measure critical contextual Implementation Science factors in each research setting in order to enable conceptualization of the mechanism of effect and, by extension, enable formalized assessments of external validity. To oversee the development and implementation of training and capacity building activities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	12/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,390,898 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	5	9/5/2024	NON-COMPETING CONTINUATION	$1,390,898
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	5/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,390,898

Issue Date FY: 2023 ( Subtotal = $1,914,241 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	9/11/2023	NON-COMPETING CONTINUATION	$1,914,241
														Subtotal = $1,914,241

Issue Date FY: 2022 ( Subtotal = $2,666,311 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	004	3	9/19/2022	SUPPLEMENT FOR EXPANSION	$752,070
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	005	3	9/20/2022	NON-COMPETING CONTINUATION	$0
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	003	3	9/15/2022	NON-COMPETING CONTINUATION	$1,914,241
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	2	7/1/2022	NON-COMPETING CONTINUATION	$0
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	2	5/28/2022	NON-COMPETING CONTINUATION	$0
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	2/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,666,311

Issue Date FY: 2021 ( Subtotal = $1,990,173 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	8/30/2021	NON-COMPETING CONTINUATION	$1,990,173
														Subtotal = $1,990,173

Issue Date FY: 2020 ( Subtotal = $1,510,020 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	9/10/2020	NEW	$1,510,020
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	1	9/19/2020	NEW	$0
														Subtotal = $1,510,020

Grand Total All Awards = $9,471,643

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Implementation Research Strategies for Heart, Lung, and Blood Co-morbidities in People Living with HIV - Research Coordinating Center

Award Number: U24HL154426

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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