Saturday, November 15, 2025 11/15/2025

Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.

Award Number: U24HL138660
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc. - PROJECT SUMMARY/ABSTRACT Hematopoietic cell transplantation (HCT) and adoptive cellular therapy (ACT) offer curative treatment for di- verse malignant and non-malignant diseases. This field is rapidly developing new strategies for patient assess- ment, cell selection and manipulation, and pre- and post-procedure treatment. New prophylactic and therapeu- tic modalities require evaluation in definitive clinical trials, as does the role of HCT versus other therapies. HCT/ACT trials face unique challenges, including the small number of procedures done at each center, the di- verse indications for treatment requiring dissimilar approaches, the complexity of the interventions, the multi- ple, competing risks in the early post-treatment period, and important, though infrequent, late effects. The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) was established in 2001 to perform scientifi- cally meritorious, prospective clinical trials to address these issues. The Network has launched 62 trials with the support of a Data Coordinating Center (DCC) formed through a consortium of organizations with synergis- tic expertise: the Medical College of Wisconsin (MCW), the National Marrow Donor Program (NMDP), and The Emmes Company. This unique Consortium leverages the critically important real-world database of the Center for International Blood and Marrow Transplant Research (CIBMTR), jointly operated by MCW and NMDP. The DCC consortium proposes to continue supporting the Network and use its expertise to provide efficient devel- opment, implementation, and completion of high-quality clinical trials, including concept evaluation and prioriti- zation; protocol development with appropriate and innovative statistical designs; timely activation and accrual; monitoring for safety, compliance, and data accuracy; and analyzing and disseminating results. The DCC con- sortium will coordinate and support all BMT CTN activities by: maintaining a state-of-the-art, secure database and systems for acquisition and storage of biospecimens, including development of a repository of longitudinal, clinically annotated specimens from a diverse cross-section of patients receiving cell and gene therapies for non-malignant blood diseases; ensuring data quality, laboratory compliance, and adherence to regulatory re- quirements; managing contractual arrangements and fiscal activities; monitoring and improving center and overall Network performance; supporting logistics for Network Committees and activities; enhancing access to trials for all patients regardless of ancestry, demographics or socioeconomics; and fostering the next genera- tion of researchers from diverse backgrounds by providing didactics, mentorship, and meaningful career-en- hancing experiences. The DCC will continue to leverage Network resources and expertise by collaborating with the National Cancer Institute-funded National Clinical Trials Network Groups, CIBMTR’s Working Committees, industry partners, and advocacy groups. These collaborations will maximize completion of scientifically rigor- ous, clinically relevant, innovative HCT/ACT clinical trials, especially for non-malignant blood disorders and with novel cell/gene therapies, including those that require collaboration with non-HCT/ACT investigators.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $7,236,292 )
2025	2025	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	002	9	7/29/2025	NON-COMPETING CONTINUATION	$7,236,292
2025	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	8	2/24/2025	COMPETING CONTINUATION	$5,520,440
2025	2023	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	7	2/24/2025	NON-COMPETING CONTINUATION	-$5,520,440
														Subtotal = $7,236,292

Issue Date FY: 2024 ( Subtotal = $5,158,467 )
2024	2024	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	8	8/30/2024	COMPETING CONTINUATION	$5,158,467
2024	2023	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	7	8/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,158,467

Issue Date FY: 2023 ( Subtotal = $8,077,245 )
2023	2023	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	7	8/23/2023	NON-COMPETING CONTINUATION	$8,077,245
														Subtotal = $8,077,245

Issue Date FY: 2022 ( Subtotal = $7,131,105 )
2022	2022	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	6	8/15/2022	NON-COMPETING CONTINUATION	$7,131,105
														Subtotal = $7,131,105

Issue Date FY: 2021 ( Subtotal = $8,815,066 )
2021	2021	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	5	8/18/2021	NON-COMPETING CONTINUATION	$8,815,066
2021	2020	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	4	5/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,815,066

Issue Date FY: 2020 ( Subtotal = $8,878,377 )
2020	2020	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	4	8/28/2020	NON-COMPETING CONTINUATION	$8,878,377
2020	2019	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	3	6/18/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $8,878,377

Issue Date FY: 2019 ( Subtotal = $9,032,290 )
2019	2019	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	004	3	8/22/2019	SUPPLEMENT FOR EXPANSION	$1,670,546
2019	2019	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	003	3	7/22/2019	NON-COMPETING CONTINUATION	$7,314,230
2019	2018	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	002	2	2/26/2019	NON-COMPETING CONTINUATION	$0
2019	2017	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	1	1/31/2019	NEW	$47,514
2019	2017	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	1	2/7/2019	NEW	$0
														Subtotal = $9,032,290

Issue Date FY: 2018 ( Subtotal = $11,562,129 )
2018	2018	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	2	7/26/2018	NON-COMPETING CONTINUATION	$5,371,075
2018	2017	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	1	4/30/2018	NEW	$6,191,054
														Subtotal = $11,562,129

Issue Date FY: 2017 ( Subtotal = $4,456,753 )
2017	2017	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	000	1	8/22/2017	NEW	$4,456,753
2017	2017	MEDICAL COLLEGE OF WISCONSIN, INC., THE	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Blood Diseases and Resources Research	001	1	9/8/2017	NEW	$0
														Subtotal = $4,456,753

Grand Total All Awards = $70,347,724

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Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.

Award Number: U24HL138660

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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