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CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models

Award Number: U24HG013078
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/24/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models - Project Summary and Abstract The processes underlying human health and disease are highly complex. This necessitates the creation, organization, and dissemination of vast amounts of relevant scientific data. Organizing this information into databases and user-friendly web sites and tools is therefore an integral component of ongoing efforts to understand and ultimately improve human health. Many human diseases are now appreciated to result from genetic and environmental perturbations to gene regulatory mechanisms. As direct readers of genomic regulatory sequences, transcription factors (TFs) and RNA-binding proteins (RBPs) are primary components of gene regulatory mechanisms. Accordingly, the nucleic acid binding specificities of TFs and RBPs (henceforth, “specificities”) provide foundational knowledge for understanding the processes underlying human health and disease states. Comprehensive mapping of TF and RBP specificities is thus regarded as a major goal in the fields of human genetics, functional genomics, and bioinformatics. We aim to ultimately achieve this goal and disseminate the resulting data freely to the research community. To this end, we created the CisBP and CisBP-RNA TF and RBP specificity databases over 10 years ago. Since then, we have improved upon these resources through periodic updates incorporating new experimental data generated in our labs and others. Since their creation, these unique resources have been heavily utilized by the research community, with over 60,000 unique users and over 2,800 citations to date. Our ongoing efforts to maintain and improve CisBP and CisBP-RNA have enabled the comprehensive study of gene regulation in healthy and disease states in humans and other organisms relevant to human health. In this proposal, we seek to build upon these powerful resources by improving the database contents and underlying computational infrastructure (Aim 1), incorporating newly generated specificity data for TFs and RBPs from human viruses and other important human pathogens (Aim 2), and enhancing the user experience through improved web sites, web tools, and community outreach efforts (Aim 3). Implementation of these improvements will directly lead to increased database update frequencies, improved user experiences, a large and more knowledgeable user community, and new data for studying the role of gene regulation in human healthy and disease states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $488,769 )
2026	2026	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Human Genome Research	000	3	7/7/2026	NON-COMPETING CONTINUATION	$488,769
														Subtotal = $488,769

Issue Date FY: 2025 ( Subtotal = $544,784 )
2025	2025	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Human Genome Research	000	2	6/9/2025	NON-COMPETING CONTINUATION	$544,784
														Subtotal = $544,784

Issue Date FY: 2024 ( Subtotal = $573,116 )
2024	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Human Genome Research	000	1	6/24/2024	NEW	$573,116
														Subtotal = $573,116

Grand Total All Awards = $1,606,669

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CisBP and CisBP-RNA: web resources for protein-DNA and protein-RNA binding models

Award Number: U24HG013078

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/24/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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