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WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center

Award Number: U24HG012070
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/24/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center - PROJECT SUMMARY The goals of the WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center (IGVF-DACC) component of the IGVF Consortium are to collect, store, curate, and display all data, metadata, and analysis tools generated by the IGVF Consortium. The DACC will assist in developing and disseminating metadata and standards to be adopted by the community at large, approaches for integrative analysis of a wide range of data types, and visualization and analysis tools to facilitate access and understanding of complex datasets to non-expert users. Ultimately, the IGVF Consortium will produce tools, analyses, models, and data that form the catalog of variants and their functional impact. We will develop the DACC into a substantial service organization allowing scientific research to take full advantage of the IGVF reference catalog or map. To support the IGVF Consortium, we will establish databases with an application framework to facilitate complex data loading. We will include detailed experimental descriptions and metadata. We will define and develop pipelines that connect all Consortium members to the data and create avenues of access that distribute the data to the greater biological research community. We will establish metadata requirements, controlled vocabularies, standardized data formats, and quality control metrics for all IGVF data. We will bring together laboratories that generate complex data types via experimental assays with laboratories that integrate these data using computational tools to define the effects of genomic variation on genome function and how these effects shape phenotypes. By creating structures and data flow pipelines for the verification and validation of all data and providing processes for the documentation of metadata, the DACC will enhance the IGVF data production. The DACC will also coordinate integrative data analysis by creating and adapting analysis pipelines and developing advanced Genome Browser functions for the visual integration of IGVF data. Also, we will make the IGVF Web Portal that will be the primary entry point to the wealth of experimental data and computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Finally, the DACC will provide documentation, training, and outreach via many media, including written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	5	5/20/2026	NON-COMPETING CONTINUATION	$0
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	002	5	7/2/2026	NON-COMPETING CONTINUATION	$0
2026	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	5	2/25/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,546,050 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	5	7/16/2025	NON-COMPETING CONTINUATION	$1,546,050
2025	2024	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	4	1/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,546,050

Issue Date FY: 2024 ( Subtotal = $1,546,049 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Human Genome Research	000	4	5/20/2024	NON-COMPETING CONTINUATION	$1,546,049
														Subtotal = $1,546,049

Issue Date FY: 2023 ( Subtotal = $1,577,601 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	3	5/18/2023	NON-COMPETING CONTINUATION	$1,577,601
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	2	11/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,577,601

Issue Date FY: 2022 ( Subtotal = $2,493,199 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	2	5/31/2022	NON-COMPETING CONTINUATION	$1,577,601
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	001	2	9/28/2022	NON-COMPETING CONTINUATION	$915,598
														Subtotal = $2,493,199

Issue Date FY: 2021 ( Subtotal = $1,010,610 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Human Genome Research	000	1	8/24/2021	NEW	$1,010,610
														Subtotal = $1,010,610

Grand Total All Awards = $8,173,509

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WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center

Award Number: U24HG012070

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/24/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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