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NHGRI Sample Repository for Human Genetic Research

Award Number: U24HG008736
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/08/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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NHGRI Sample Repository for Human Genetic Research - Project Summary We propose the renewal of the NHGRI Sample Repository for Human Genetic Research (NHGRI Repository), which was established in 2006 at the Coriell Institute for Medical Research (Coriell) and facilitates studies of human genetic and genomic variation by establishing, characterizing and distributing a large (N>3,700), publicly available collection of biospecimens obtained from human populations living around the world, including the prominent HapMap, 1000 Genomes Project, and Human Pangenome Reference Consortium (HPRC) cell line and DNA collections. This collection is available to the research community and is characterized with publicly available whole genome sequencing (WGS) data as well as other large-scale genomic data. Importantly, the NHGRI Repository biospecimens offer a renewable resource that is critical for rigorous and reproducible research, new method validation, and serves as reference materials for a wide range of genetic assays. The NHGRI Repository additionally includes an associated suite of user-friendly, web-based, genomic data search tools for researchers that prefer to explore the large genomic datasets collected from NHGRI Repository samples without the need for command line approaches. We propose to continue Coriell’s strong track record in the management, maintenance and global distribution of this foundational genomic resource, as well as new efforts to expand the collection and impact of the resource to ensure that the NHGRI Repository remains relevant and meets the growing needs of the research community. Our proposed renewal goals include maintaining and distributing high-quality and well-characterized biospecimens to the scientific community through Coriell’s online catalog and providing tailored customization of sample preparations to meet varied scientific needs. We propose to grow the NHGRI Repository collection with the addition of new sample submissions collected for the HPRC and with the expansion of the NHGRI Repository induced pluripotent stem cell (iPSC) collection. We additionally plan to continue launching new web-based, genomic data search tools of robust public datasets, with an emphasis on new long-read, whole genome sequencing data sets such as the HPRC data. Coriell is equally committed to educating the public and outreach to the scientific community about the NHGRI Repository collections through participation in educational events, attendance at scientific conferences, and through the NHGRI Repository’s public facing website. The NHGRI Repository team directly engages with researchers that have submitted samples to the NHGRI Repository and through them with members of the various donor communities. In this manner, global communities that have generously donated their biospecimens to the NHGRI Repository stay informed about the impact that their contribution is making to research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $866,678 )
2026	2026	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	002	11	9/1/2026	COMPETING CONTINUATION	$866,678
2026	2025	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	001	10	8/24/2026	NON-COMPETING CONTINUATION	$0
2026	2025	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	10	3/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $866,678

Issue Date FY: 2025 ( Subtotal = $864,373 )
2025	2025	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	10	9/10/2025	NON-COMPETING CONTINUATION	$864,373
														Subtotal = $864,373

Issue Date FY: 2024 ( Subtotal = $884,735 )
2024	2024	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	9	6/24/2024	NON-COMPETING CONTINUATION	$884,735
														Subtotal = $884,735

Issue Date FY: 2023 ( Subtotal = $923,080 )
2023	2023	CORIELL INSTITUTE FOR MEDICAL RESEARCH INC	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	8	5/18/2023	NON-COMPETING CONTINUATION	$923,080
														Subtotal = $923,080

Issue Date FY: 2022 ( Subtotal = $942,886 )
2022	2022	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	002	7	5/27/2022	NON-COMPETING CONTINUATION	$942,886
2022	2021	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	6	10/9/2021	COMPETING CONTINUATION	$0
2022	2021	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	001	6	3/2/2022	COMPETING CONTINUATION	$0
														Subtotal = $942,886

Issue Date FY: 2021 ( Subtotal = $949,735 )
2021	2021	CORIELL INSTITUTE FOR MEDICAL RESEARCH, INC.	403 HADDON AVE	CAMDEN	NJ	08103	CAMDEN	USA	Human Genome Research	000	6	8/16/2021	COMPETING CONTINUATION	$949,735
														Subtotal = $949,735

Grand Total All Awards = $5,431,487

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NHGRI Sample Repository for Human Genetic Research

Award Number: U24HG008736

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/08/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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