Tuesday, February 11, 2025
2/11/2025
PROJECT SUMMARY Sponsored by the NHGRI and established at the Coriell Institute in 2006, the NHGRI Sample Repository for Human Genetic Research provides a publically accessible, and centralized resource of well-characterized biospecimens from a wide range of global human populations, including the 1000 Genomes Project collection, for use in biomedical research. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic and genomic variation by establishing, maintaining, and distributing a repository of high-quality, renewable, reproducible, well-characterized, and broadly consented cell lines and DNA. The NHGRI Repository is a global resource that has been used by thousands of investigators to support countless research studies. Since its inception, over two hundred thousand cell lines, DNA and RNA samples have been distributed to researchers in 50 countries around the world, and thousands of scientific articles have resulted from studies using these samples and associated data. Proposed NHGRI Repository activities include: (1) maintaining inventory and distributing NHGRI Repository cell lines and DNA samples for the existing repository collection, (2) distributing custom preparations and lots of DNA, High Molecular Weight (HMW) DNA, RNA, cell pellets, and custom plates and panels as requested by the scientific community, (3) expanding the repository to include biospecimen submissions from the Human Pangenome Reference Consortium and creating a new panel of induced pluripotent stem cells that will encompass a wide range of genomic variation to meet the growing needs of the research community, and (4) maintaining a comprehensive and secure database and public online catalog for NHGRI Repository activities, and engaging the scientific community and public at large through scientific presentations, conferences, educational events, and community reports. With over 50 years of NIH-sponsored biobanking expertise, Coriell is uniquely qualified to achieve these aims and strategically expand the operations and offerings of the NHGRI Repository. The goals of the NHGRI Repository are consistent with the NHGRI’s mission to support development of resources and technology that accelerate genomic research. Coriell is a trusted NIH partner and has the infrastructure, expertise, and track-record to ensure the successful operations, maintenance and growth of this important and unique genomic resource.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).