Wednesday, July 2, 2025 7/2/2025

Bioconductor: An Open-Source, Open-Development Computing Resource for Genomics

Award Number: U24HG004059
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/28/2006
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Bioconductor: An Open-Source, Open-Development Computing Resource for Genomics - PROJECT SUMMARY Bioconductor is a project dedicated to the analysis and interpretation of high throughput genomic data, includ- ing sequencing, microarray, ﬂow cytometry, proteomics, and imaging data. Bioconductor is based on the R sta- tistical programming language. It consists of software, annotation, and data packages developed and contributed by individuals funded by this grant, and by the national and international scientiﬁc community. Bioconductor is highly respected, widely used in the global bioinformatics community, highly cited, and has formal collaborative alignments with the Human Cell Atlas and NHGRI's Genomic Analysis, Visualization, and Informatics Lab Space (AnVIL). Work proposed in this renewal application reﬂects the commitment of the project to open-source/open- development creation and distribution of portable tools for genomic data science, high-quality documentation and support for users and developers, adaptation of computational methods to new technologies for cloud-scale data science, and effective training of the workforce for genome biology and personalized genomic medicine. The spe- ciﬁc aims are (1) maintenance and enhancement of the system at bioconductor.org for organizing and distributing analytic software, reference data, and curated experimental data, (2) hardening of core infrastructural software packages to increase reliability and throughput of analyses based on the system, (3) conduct research and devel- opment of best practices for taking advantage of scalable computing strategies for integrative cloud-scale genomic analysis, and (4) enhance community engagement and education practices that have been intrinsic to the project since its inception. By pursuing these aims, project investigators and contributors add to the usability, relevance, and robustness of a system and community that is unique and is uniquely situated to accelerate progress in many areas of genomic data science, ultimately contributing to biological knowledge and improvement of human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,025,369 )
2025	2025	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	21	3/27/2025	NON-COMPETING CONTINUATION	$922,833
2025	2025	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	001	21	4/25/2025	NON-COMPETING CONTINUATION	$102,536
														Subtotal = $1,025,369

Issue Date FY: 2024 ( Subtotal = $1,095,152 )
2024	2024	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	003	20	7/5/2024	NON-COMPETING CONTINUATION	-$22,350
2024	2024	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	002	20	5/8/2024	NON-COMPETING CONTINUATION	$1,117,502
2024	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	000	19	2/28/2024	NON-COMPETING CONTINUATION	$34,932
2024	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	001	19	3/21/2024	NON-COMPETING CONTINUATION	-$34,932
														Subtotal = $1,095,152

Issue Date FY: 2023 ( Subtotal = $1,547,206 )
2023	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	19	3/10/2023	NON-COMPETING CONTINUATION	$1,319,702
2023	2023	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Human Genome Research	002	19	9/6/2023	SUPPLEMENT FOR EXPANSION	$227,504
2023	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	18	11/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,547,206

Issue Date FY: 2022 ( Subtotal = $1,324,035 )
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	18	4/29/2022	NON-COMPETING CONTINUATION	$1,324,035
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	18	6/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,324,035

Issue Date FY: 2021 ( Subtotal = $2,007,878 )
2021	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	17	3/12/2021	COMPETING CONTINUATION	$1,335,931
2021	2021	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	17	8/26/2021	COMPETING CONTINUATION	$671,947
														Subtotal = $2,007,878

Grand Total All Awards = $6,999,640

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Bioconductor: An Open-Source, Open-Development Computing Resource for Genomics

Award Number: U24HG004059

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/28/2006

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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