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 | Issue Date FY: 2025 ( Subtotal = $11,134,243 ) (Continued on the next page) |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R37CA255245 | Targeting vulnerabilities of PPM1D-mutant gliomas | 000 | 5 | NIH | 1/13/2025 | $363,246 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K08CA279891 | Epigenetic regulators define a dynamic chromatin landscape in NUP98-rearranged leukemia | 000 | 2 | NIH | 1/27/2025 | $215,179 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K99CA286805 | Dissecting the Role of Germline Genetics in RAS-Driven Cancers | 000 | 2 | NIH | 1/13/2025 | $163,728 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA265928 | A precision tumor neoantigen identification pipeline for cytotoxic T-lymphocyte-based cancer immunotherapies | 000 | 4 | NIH | 1/28/2025 | $606,827 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K00CA245819 | Investigating Immune Responses to Neoantigen Cancer Vaccines using In Vivo Functionalized Lineage | 000 | 6 | NIH | 12/10/2024 | $105,840 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | U01CA218651 | End-of-life care quality for adolescents and young adults with cancer: Including the patient voice in quality assessment | 000 | 6 | NIH | 1/14/2025 | $725,836 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R25CA181000 | Workshop on Research Methods in Supportive Oncology | 001 | 11 | NIH | 1/31/2025 | $104,415 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R37AI039394 | Biochemical Mechanism of HIV DNA Integration | 000 | 30 | NIH | 1/14/2025 | $819,601 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R21CA296230 | Targeting the CDK4/6 pathway in MiT/TFE-translocation renal cell carcinoma | 000 | 1 | NIH | 1/30/2025 | $267,298 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K99GM154065 | Towards a structural understanding of transcriptional regulation by ZMYM2-KDM1A-CoREST | 000 | 1 | NIH | 12/18/2024 | $125,000 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA296618 | Exploiting a Novel DNA Repair Defect in Ewing Sarcoma | 000 | 1 | NIH | 12/4/2024 | $523,292 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K01DK141969 | The mechanistic study on irisin-mediated immune response and its role in adipose tissue dynamics | 000 | 1 | NIH | 12/5/2024 | $152,454 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K00AG078230 | Effects of Extracellular Mechanics on Mechanosensory and Central Neuron Function | 000 | 6 | NIH | 12/17/2024 | $98,685 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R35GM157235 | Molecular mechanisms of DNA double strand break repair by homologous recombination | 000 | 1 | NIH | 1/22/2025 | $445,000 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA201049 | Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M | 000 | 10 | NIH | 11/27/2024 | $441,496 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R00CA266921 | SESORRS endoscopy for the staging and evaluation of colorectal cancer | 000 | 4 | NIH | 12/23/2024 | $170,893 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA279414 | A multi-level examination of the influences of racism on cancer pain equity | 000 | 2 | NIH | 1/8/2025 | $653,887 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA278980 | Dissecting Convergent Somatic and Germline Alterations that Mediate the Origins and Evolution of Kidney Cancer | 000 | 2 | NIH | 11/27/2024 | $622,014 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | U01AI165442 | Identification of Metabolic and Immune Deficits in the Aged Population and Their Restoration to Achieve Youthful Anti-Influenza Vaccine Responsiveness | 000 | 4 | NIH | 11/5/2024 | $1,169,078 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA221874 | Comprehensive minimal residual disease tracking in cancer | 000 | 5 | NIH | 11/4/2024 | $399,996 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01HL052725 | Molecular Pathogenesis of Fanconi Anemia | 000 | 30 | NIH | 1/8/2025 | $445,000 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K01DK132455 | The Role of Mitochondrial TNAP in Adaptive Thermogenesis | 000 | 3 | NIH | 11/13/2024 | $127,781 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01HL171973 | Molecular mechanisms of splicing dependency in cohesin-mutant myelodysplasia | 000 | 2 | NIH | 11/18/2024 | $400,500 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R37CA269990 | Mechanisms by which LSD1 Promotes Neuroendocrine Differentiation and Small Cell Lung Cancer | 000 | 3 | NIH | 11/6/2024 | $420,355 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R61CA278449 | New Chemical Tools for Covalent Drug Discovery | 000 | 2 | NIH | 1/9/2025 | $224,681 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01HL158269 | Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms | 000 | 5 | NIH | 1/17/2025 | $442,500 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01AG075837 | Contribution of a novel OPN-producing CD11c+ microglial subset to AD | 000 | 2 | NIH | 12/6/2024 | $455,377 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA266194 | Selective disruption of histone deacetylase complexes using protein interaction modulators | 000 | 4 | NIH | 1/15/2025 | $612,114 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA276268 | Mechanisms of response and resistance to KRAS inhibition in pancreatic cancer | 000 | 3 | NIH | 12/16/2024 | $505,595 |
| | 2025 | 2025 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA276156 | Mechanisms of natural killer cell resistance of treatment-persistent residual tumor cells in hematologic malignancies | 000 | 3 | NIH | 11/22/2024 | $362,793 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | F32DK132864 | Elucidating novel molecular mechanisms of irisin-mediated effects via integrin | 000 | 3 | NIH | 1/22/2025 | -$22,164 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R35CA253125 | The role of clonal hematopoiesis in the development and therapy of myeloid malignancies | 000 | 5 | NIH | 1/28/2025 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K01DK125639 | Mesenchymal regulation of fetal intestinal development and adult regeneration | 000 | 5 | NIH | 11/29/2024 | -$103,879 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | U01CA246648 | A web-based patient-reported symptom monitoring and self-management portal for adolescent and young adult breast cancer survivors | 000 | 3 | NIH | 1/15/2025 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA188446 | A novel flat-panel detector for advanced on-board radiation therapy imaging | 000 | 10 | NIH | 11/14/2024 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K99HG012798 | Robust and cost-effective computational methods for haplotype-resolved genome assemblies | 000 | 2 | NIH | 11/26/2024 | -$5,924 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | U24HG011451 | Generating a full-length reference transcriptome for human protein-coding genes | 000 | 3 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01CA284565 | Enhanced radiotherapy for pediatric glioma via synthetic lethal vulnerabilities | 000 | 1 | NIH | 12/23/2024 | $291,016 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R01HG013083 | Integrative modelling of single-cell data to elucidate the genetic architecture of complex disease | 000 | 1 | NIH | 12/16/2024 | $24,403 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K00CA264296 | Exploiting oncogenic chromatin regulators in cancer initiation and progression | 000 | 3 | NIH | 12/26/2024 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | P30CA006516 | Dana-Farber/Harvard Cancer Center | 000 | 59 | NIH | 1/15/2025 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | P30CA006516 | Dana-Farber/Harvard Cancer Center | 001 | 59 | NIH | 1/16/2025 | $0 |
| | 2025 | 2024 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K24HL173664 | Collaborative Care to Improve Resilience and Quality of Life among Youth with Non-malignant Blood Disorders | 000 | 1 | NIH | 1/10/2025 | $0 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K99CA279915 | Defining PRC1.1 as a gatekeeper of lineage plasticity and response to anti-GD2 therapy | 000 | 1 | NIH | 10/11/2024 | -$6,832 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K99AG073461 | Defining the landscape and mechanisms of redox regulation of metabolism during aging | 000 | 2 | NIH | 12/19/2024 | $0 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | R21CA270069 | Development of A Mindfulness-Based Mobile Health Intervention for Patients Coping with Pain from Advanced Malignancies | 000 | 2 | NIH | 1/30/2025 | -$103 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | F32CA261034 | Lipid metabolism as a therapeutic vulnerability in BET inhibitor-resistant medulloblastoma | 000 | 3 | NIH | 1/23/2025 | -$11,850 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | K08CA263555 | The Impact of Donor Hematopoietic DNMT3A Mutations in Stem Cell Transplant Recipients | 000 | 3 | NIH | 10/23/2024 | -$31,808 |
| | 2025 | 2023 | DANA-FARBER CANCER INSTITUTE, INC. | 450 BROOKLINE AVE | BOSTON | MA | 02215-5418 | SUFFOLK | USA | F32CA254118 | Identifying Combination Therapies in Ovarian Tumors using High Throughput Dynamic BH3 Profiling | 002 | 3 | NIH | 1/23/2025 | -$23,290 |
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