Friday, April 19, 2024 4/19/2024

Genome Sequencing in support of the Gabriella Miller Kids First Pediatric Research Program

Award Number: U24HD090743
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract We propose to continue to provide data generation and processing activities that will enrich a genomic data resource to propel pediatric disease research and in particular for the study of Brian Tumors. Key elements for success will be the provision of high quality genome sequence data on well-phenotyped patients and their families; the collection and accessibility of data to the research community in an intuitive manner; and the integration of genetic data with phenotypic information in the context of this program and comparison to other large data resources. We propose to continue as a Kids First Sequencing Center at the Broad Institute as we have done for the past five years for the program and as we have also done in support of other large flagship NIH genome projects. Our center brings the domain expertise in high throughput data generation, processing and analysis, and disease gene discovery required to meet the objectives of the Kids First Program. We will apply deep, high-quality whole genome sequencing and RNA sequencing data on selected samples. We will be flexible to work closely and accommodate the needs and interests of selected X01 Investigators. We will participate in the evaluation of these data types and their overall impact on discovery and scientific output of the program. A key feature of our center is our implementation of a robust analytical framework for variant assessment and disease gene discovery, which builds on Broad investigators’ world- leading roles in statistical genetics, functional annotation, and clinical variant interpretation as well as access to exome and genome data from hundreds of thousands of samples sequenced at Broad. This has enabled us to build a systematic pipeline for gene discovery that will be made freely available to the Kids First program. With data produced and processed in a consistent way, we can offer seamless integration of Kids First data into our analytic framework. For many of the diseases targeted by the pediatric research community, confident discovery of causal genes will require aggregation of cases across centers around the world. We will partner with the Kids First Data Resource Center in a variety of ways to ensure that the program is well- aligned with other large-scale resource generation projects. With this we hope to support Kids First as a whole and establish standards for data sharing in clinical genomics, accelerating collaboration and facilitating robust disease gene discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	000	8	2/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $6,700,387 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	007	8	8/31/2023	NON-COMPETING CONTINUATION	$5,587,520
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	008	8	9/2/2023	SUPPLEMENT FOR EXPANSION	$1,129,250
2023	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	004	7	12/29/2022	COMPETING CONTINUATION	$1,630,494
2023	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	005	7	2/8/2023	COMPETING CONTINUATION	$0
2023	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	000	7	11/7/2022	COMPETING CONTINUATION	$0
2023	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	6	12/29/2022	NON-COMPETING CONTINUATION	-$470,057
2023	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	003	6	12/29/2022	SUPPLEMENT FOR EXPANSION	-$847,039
2023	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	6	12/29/2022	SUPPLEMENT FOR EXPANSION	-$313,398
2023	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	006	3	3/22/2023	NON-COMPETING CONTINUATION	-$16,383
														Subtotal = $6,700,387

Issue Date FY: 2022 ( Subtotal = $4,735,797 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	000	7	9/21/2022	COMPETING CONTINUATION	$4,719,414
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Trans-NIH Research Support	001	7	9/23/2022	COMPETING CONTINUATION	$0
2022	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	3	9/28/2022	NON-COMPETING CONTINUATION	$16,383
														Subtotal = $4,735,797

Issue Date FY: 2021 ( Subtotal = $9,624,675 )
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	6	9/15/2021	SUPPLEMENT FOR EXPANSION	$1,849,965
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	003	6	9/16/2021	SUPPLEMENT FOR EXPANSION	$5,000,000
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	6	9/7/2021	NON-COMPETING CONTINUATION	$2,774,710
2021	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	5	2/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $9,624,675

Issue Date FY: 2020 ( Subtotal = $7,333,873 )
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	004	5	9/4/2020	NON-COMPETING CONTINUATION	$7,333,873
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	003	4	1/3/2020	COMPETING CONTINUATION	$0
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	4	1/2/2020	COMPETING CONTINUATION	$4,794,953
2020	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	3	1/2/2020	NON-COMPETING CONTINUATION	-$2,794,953
2020	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	3	1/2/2020	SUPPLEMENT FOR EXPANSION	-$2,000,000
														Subtotal = $7,333,873

Issue Date FY: 2019 ( Subtotal = $4,010,000 )
2019	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	4	9/12/2019	COMPETING CONTINUATION	$4,010,000
2019	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	3	1/11/2019	NON-COMPETING CONTINUATION	$0
2019	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	2	1/14/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,010,000

Issue Date FY: 2018 ( Subtotal = $6,679,955 )
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	3	9/5/2018	NON-COMPETING CONTINUATION	$0
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	3	8/29/2018	NON-COMPETING CONTINUATION	$4,679,955
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	002	3	9/13/2018	SUPPLEMENT FOR EXPANSION	$2,000,000
														Subtotal = $6,679,955

Issue Date FY: 2017 ( Subtotal = $4,830,221 )
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	2	7/13/2017	NON-COMPETING CONTINUATION	$4,737,577
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	2	8/1/2017	SUPPLEMENT FOR EXPANSION	$92,644
														Subtotal = $4,830,221

Issue Date FY: 2016 ( Subtotal = $6,300,000 )
2016	2016	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	1	9/22/2016	NEW	$6,300,000
														Subtotal = $6,300,000

Grand Total All Awards = $50,214,908

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Genome Sequencing in support of the Gabriella Miller Kids First Pediatric Research Program

Award Number: U24HD090743

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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