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NCCAT: National Center for CryoEM Access and Training

Award Number: U24GM129539
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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NCCAT: National Center for CryoEM Access and Training - Summary We propose to establish the National Center for CryoEM Access and Training (NCCAT) to be housed at the Simons Electron Microscopy Center (SEMC), which is a part of the New York Structural Biology Center (NYSBC), based in New York, NY. NCCAT will provide access to state-of-the-art equipment, including specimen preparation robots, high-end microscopes and direct detectors, screening microscopes, and all the other ancillary equipment required to solve structures to the highest possible resolution using cryo electron microscopy (cryoEM) methods. A highly qualified technical team will provide direct support, guidance and assistance to ensure that structures of the highest quality are produced in the shortest possible time. An already well established cross-training program will be expanded and extended to provide training across a wide variety of skill levels and career goals. NCCAT will adopt an open and transparent application process to ensure equal-opportunity nationwide access. The operations at NCCAT will build on already established practices at SEMC/NYSBC and benefit from the overall vibrant environment as well as the expertise of many of the highly trained staff already in place. NCCAT will be housed in new, custom-built space that will provide optimal, environmentally stable conditions. The major instrumentation will consist of 3 Titan Krios TEMs equipped with direct detectors, energy filters and phase plates, and 3 screening microscopes equipped with CMOS cameras. Streamlined workflows, already well established, will expanded to ensure that we collect the highest quality data as efficiently as possible. A user service operation will provide on-site, remote-access, and mail-in data collection services with fair and equal access to a nationwide user base. We will guide and assist users with all aspects of cryoEM, including sample preparation, data collection and image processing. A training program will encompass a full range of expectations, from the basics required to ensure that users produce valid structures, through more detailed training for users seeking independence, to fully embedded researchers who will be expected to graduate to running their own cryoEM research laboratories. While we anticipate that we will initially be called to serve and train mostly in the area of single particle cryoEM, we are well positioned to provide support in the area of cryoET that we predict will grow rapidly. While the goals of NCCAT are not innately innovative it is our intention to set the standard as one of the first world class, nationally accessible cryoEM access and training facilities that is freely and fairly available to all researchers in the US, and to continually strive to enable science of the highest quality and value.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$2 )
2025	2023	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	6	2/6/2025	NON-COMPETING CONTINUATION	-$2
														Subtotal = -$2

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	6	11/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $4,927,146 )
2023	2023	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	002	6	6/27/2023	NON-COMPETING CONTINUATION	$4,647,846
2023	2023	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	004	6	9/19/2023	SUPPLEMENT FOR EXPANSION	$279,300
2023	2022	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	003	5	8/7/2023	NON-COMPETING CONTINUATION	$0
2023	2022	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	5	1/3/2023	NON-COMPETING CONTINUATION	$0
2023	2022	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	001	5	3/22/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,927,146

Issue Date FY: 2022 ( Subtotal = $5,617,402 )
2022	2022	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	002	5	8/12/2022	SUPPLEMENT FOR EXPANSION	$318,297
2022	2022	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	001	5	4/28/2022	NON-COMPETING CONTINUATION	$5,000,000
2022	2022	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	004	5	8/16/2022	SUPPLEMENT FOR EXPANSION	$25,980
2022	2022	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	003	5	8/15/2022	SUPPLEMENT FOR EXPANSION	$273,125
2022	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	4	1/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,617,402

Issue Date FY: 2021 ( Subtotal = $8,058,141 )
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	001	4	9/16/2021	SUPPLEMENT FOR EXPANSION	$279,300
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	002	4	9/17/2021	SUPPLEMENT FOR EXPANSION	$245,507
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	4	4/16/2021	NON-COMPETING CONTINUATION	$7,533,334
														Subtotal = $8,058,141

Issue Date FY: 2020 ( Subtotal = $14,505,006 )
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	003	3	9/17/2020	SUPPLEMENT FOR EXPANSION	$2,000,000
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	002	3	9/10/2020	SUPPLEMENT FOR EXPANSION	$47,738
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	001	3	4/17/2020	NON-COMPETING CONTINUATION	$12,342,435
2020	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	2	2/27/2020	NON-COMPETING CONTINUATION	$114,833
														Subtotal = $14,505,006

Issue Date FY: 2019 ( Subtotal = $12,306,059 )
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	002	2	9/10/2019	NON-COMPETING CONTINUATION	$0
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	2	8/6/2019	SUPPLEMENT FOR EXPANSION	$7,596,956
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	2	5/1/2019	NON-COMPETING CONTINUATION	$4,709,103
														Subtotal = $12,306,059

Issue Date FY: 2018 ( Subtotal = $8,513,821 )
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Trans-NIH Research Support	000	1	5/1/2018	NEW	$8,513,821
														Subtotal = $8,513,821

Grand Total All Awards = $53,927,573

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NCCAT: National Center for CryoEM Access and Training

Award Number: U24GM129539

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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